Molecular Mechanisms of Adaptive Responses to Food and Oxygen
Molecular Mechanisms of Adaptive Responses to Food and Oxygen
批准号:
19GS0312
负责人:
YAMAMOTO Masayuki
金额:
$331.88万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Creative Scientific Research
财政年份:
2007
资助国家:
日本
项目状态:
已结题
起止时间:
2007 至 2011
中文摘要
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英文摘要
Environmental stress response system allows organisms to keep cellular homeostasis. In this study, weexamined Keap1-Nrf2-mediated oxidative and xenobiotic defense system, and identified novel molecular mechanisms for stress-sensing system and their association with diseases. We alsoidentified diverse and elaborate gene regulatory mechanisms in response to hypoxic stressthrough the comprehensive analysis of erythropoietin gene regulatory regions.
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Genetically induced ER stress in azebrafish model for human congenital disorders of glycosylation
人类先天性糖基化障碍斑马鱼模型中遗传诱导的内质网应激
DOI:
--
发表时间:
2009
期刊:
影响因子:
--
作者:
[Mukaigasa, K., Li, L., Tsujita, T., Yamamoto, M. and Kobayashi, M]
通讯作者:
M
In vivo promoter analysis on refeeding response of hepatic sterol regulatory element-binding protein-lc expression.
肝甾醇调节元件结合蛋白-lc表达的再喂养反应的体内启动子分析。
DOI:
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发表时间:
2007
期刊:
Biochem Biophys Res Commun. 363
影响因子:
--
作者:
[Takeuchi Y, Yahagi N, Nakagawa Y, Matsuzaka T, Shimizu R, Sekiya M, Iizuka Y. Ohashi K, Gotoda T, Yamamoto M, Nagai R, Kadowaki T, Yamada N, Osuga JI. and Shimano H.]
通讯作者:
Osuga JI. and Shimano H.
Nrf2ノックアウトマウスはウレタン投与による肺癌形成が阻害され、形成されたNrf2欠損癌結節はNudeマウスへの著しい生着不全を示す
在Nrf2敲除小鼠中,给予乌拉坦可抑制肺癌形成,并且所形成的Nrf2缺陷型癌结节在裸鼠中表现出明显的移植失败。
DOI:
--
发表时间:
2012
期刊:
影响因子:
--
作者:
[佐藤大希, 森口尚, 守田匡伸, 海老名雅仁, 山本雅之]
通讯作者:
山本雅之
HIF-HRE系によるエリスロポエチン遺伝子の低酸素誘導的・組織特異的転写制御機構
HIF-HRE系统缺氧诱导促红细胞生成素基因的组织特异性转录调控机制
DOI:
--
发表时间:
2011
期刊:
影响因子:
--
作者:
[鈴木教郎, 潘小青, 山本雅之]
通讯作者:
山本雅之
Transcription factor Nrf2 drives the pentose phosphate pathway and glutamine consumption in proliferating cells
转录因子 Nrf2 驱动增殖细胞中的戊糖磷酸途径和谷氨酰胺消耗
DOI:
--
发表时间:
2011
期刊:
影响因子:
--
作者:
[Yoichiro Mitsuishi, Keiko Taguchi, Hozumi Motohashi, Masayuki Yamamoto]
通讯作者:
Masayuki Yamamoto
共 270 条
視覚と触覚のリアリティを考えた溶接教育シミュレーターの開発
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批准号:22H04141
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项目类别:Grant-in-Aid for Encouragement of Scientists
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资助金额:$0.31万
-
财政年份:2022
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负责人:YAMAMOTO Masayuki
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依托单位:
仮想的に溶接技術を体験できるオンライン教育支援システムの開発
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批准号:21H04029
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项目类别:Grant-in-Aid for Encouragement of Scientists
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资助金额:$0.3万
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财政年份:2021
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负责人:YAMAMOTO Masayuki
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依托单位:
Elucidation of the lignan biosynthesis pathway in sesame seeds.
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批准号:18K05571
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.66万
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财政年份:2018
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负责人:YAMAMOTO Masayuki
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依托单位:
Identification of genes controlling the contents of sesame seed lignans
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批准号:25450003
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$3.24万
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财政年份:2013
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负责人:YAMAMOTO Masayuki
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依托单位:
Roles of stress-responsive transcription factors in health and disease
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批准号:24249015
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项目类别:Grant-in-Aid for Scientific Research (A)
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资助金额:$29.54万
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财政年份:2012
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负责人:YAMAMOTO Masayuki
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依托单位:
Analysis of leukemogenesis caused by disruption of gene regulatory mechanisms mediated by multiple transactivation domains
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批准号:24659142
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项目类别:Grant-in-Aid for Challenging Exploratory Research
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资助金额:$2.5万
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财政年份:2012
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负责人:YAMAMOTO Masayuki
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依托单位:
Mechanism of Nrf2-mediated self-renewal of hematopoietic stem cells
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批准号:23659167
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项目类别:Grant-in-Aid for Challenging Exploratory Research
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资助金额:$2.58万
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财政年份:2011
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负责人:YAMAMOTO Masayuki
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依托单位:
Studies on transcriptional regulation of genes involving synthesis of lignans and tocopherols in sesame.
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批准号:22780001
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项目类别:Grant-in-Aid for Young Scientists (B)
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资助金额:$2.58万
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财政年份:2010
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负责人:YAMAMOTO Masayuki
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依托单位:
Formative Process of Modern Typography in the 20th Century England
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批准号:21520159
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.0万
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财政年份:2009
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负责人:YAMAMOTO Masayuki
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依托单位:
Regulatory Mechanisms of Meiosis in Fission Yeast
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批准号:21227007
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项目类别:Grant-in-Aid for Scientific Research (S)
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资助金额:$132.95万
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财政年份:2009
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负责人:YAMAMOTO Masayuki
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依托单位:
Studies on transcriptional activation of genes involving synthesis of seed storage components.
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批准号:20880013
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项目类别:Grant-in-Aid for Young Scientists (Start-up)
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资助金额:$2.05万
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财政年份:2008
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负责人:YAMAMOTO Masayuki
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依托单位:
Interactions between cloud microphysical processes and vertical air motions in the tropical and midlatitude regions
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批准号:19740293
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项目类别:Grant-in-Aid for Young Scientists (B)
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资助金额:$2.42万
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财政年份:2007
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负责人:YAMAMOTO Masayuki
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依托单位:
Development of Autonomous Mobile Guide System for Persons with Visual Impairment
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批准号:18700211
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项目类别:Grant-in-Aid for Young Scientists (B)
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资助金额:$2.41万
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财政年份:2006
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负责人:YAMAMOTO Masayuki
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依托单位:
Regulatory mechanisms of meiosis
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批准号:16002010
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项目类别:Grant-in-Aid for Specially Promoted Research
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资助金额:$227.05万
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财政年份:2004
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负责人:YAMAMOTO Masayuki
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依托单位:
Transcription factor regulation of malignant cell transformation and its repression
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批准号:15027201
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项目类别:Grant-in-Aid for Scientific Research on Priority Areas
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资助金额:$37.76万
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财政年份:2003
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负责人:YAMAMOTO Masayuki
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依托单位:
Molecular mechanisms for hemato-vascular formation
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批准号:15390086
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$9.79万
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财政年份:2003
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负责人:YAMAMOTO Masayuki
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依托单位:
Analysis of biological function of regulatory network composed of bZip transcription factors
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批准号:12308036
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项目类别:Grant-in-Aid for Scientific Research (A)
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资助金额:$27.52万
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财政年份:2000
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负责人:YAMAMOTO Masayuki
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依托单位:
Development of monitoring system of toxic chemicals base on the Nrf2-dependent detoxification pathway
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批准号:12557015
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$8.58万
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财政年份:2000
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负责人:YAMAMOTO Masayuki
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依托单位:
APPLICATION OF GENE MANIPULATION TECHNOLOGY TO GENERATION OF MODEL ANIMALS FOR ENVIRONMENTAL ASSESSMENT
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批准号:12794009
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项目类别:Grant-in-Aid for University and Society Collaboration
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资助金额:$15.36万
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财政年份:2000
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负责人:YAMAMOTO Masayuki
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依托单位:
Molecular Mechanisms for the Regulation of Meiosis
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批准号:11102002
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项目类别:Grant-in-Aid for Specially Promoted Research
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资助金额:$206.66万
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财政年份:1999
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负责人:YAMAMOTO Masayuki
-
依托单位:
国内基金
海外基金
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芪冬颐心颗粒通过直接修饰Keap1激活Nrf2/ARE通路改善心脏神经官能症的机制研究
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复骨健步方通过调控Nrf2/Keap1/HO-1信号通路抑制软骨细胞铁死亡对膝骨关节炎的治疗作用及机制研究
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连翘苷通过KEAP1/NRF2途径抑制NETs诱导铁死亡缓解痛风性关节炎的机制研究
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资助金额:10.0万元
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