The regulation of the fetal growth-Assesment of feto-placental circulation and fetal growth promoting activity in the human fetus-

胎儿生长的调节-胎儿-胎盘循环的评估和人类胎儿的胎儿生长促进活性-

• 批准号: 04671006
• 负责人: MAEDA Hirotaka
• 金额: $ 1.41万
• 依托单位: KYUSHU UNIVERSITY
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for General Scientific Research (C)
• 财政年份: 1992
• 资助国家: 日本
• 起止时间: 1992 至 1994
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-04671006/
• 关键词: Human Fetus; Intrauterine growth retardation; Feto-placental circulation; Cell biology; Ultrasound velocimetry; Histopathology; Endothelial cell; 胎盤循環; 細胞増殖能; 超音波音響学; 胎児胎盤循環; 好中球; 活性酸素; 成長因子

We studied the findings to changes in the feto-placental circualtion in normal and growth retarded fetuses (IUGR). Using pulsed Doppler methodology, it was revealed that placental vascular resistance was elevated in cases of IUGR and of decreased cerebral vascular resistance in some cases. When the fetal hypoxia is superimposed, RI values in the middle cerebral artery decrease, suggesting a protective, compensatory mechanism designed to increase the blood supply to the fetal brain. From biological examination of endothelial cells in IUGR fetuses with normotensive and hypertensive women, it was evident that the serum factor cytotoxic to endothelial cell is present in cases with preeclampsia, whereas the serum growth inhibitory factor is present in cases with normotensive women. On the basis of these findings, it is suggested that 1) one of the factor which regulate fetal growth is the pathological changes in the feto-placental circulation, 2) the endothelial cell function contribute to the mechanisms which change vascular resistance in the feto-placental circulation in the human fetus.

本文研究了正常胎儿和生长迟缓胎儿（IUGR）胎儿-胎盘循环的变化。应用脉冲多普勒方法，发现胎儿宫内发育迟缓（IUGR）胎盘血管阻力增高，部分胎儿脑血管阻力降低。当胎儿缺氧叠加时，大脑中动脉的RI值降低，表明一种保护性的代偿机制，旨在增加胎儿大脑的血液供应。从生物学检查的内皮细胞在IUGR胎儿与血压正常和高血压的妇女，很明显，血清因子细胞毒性内皮细胞是存在于先兆子痫的情况下，而血清生长抑制因子是存在于血压正常的妇女的情况下。提示：1）胎儿-胎盘循环的病理改变是胎儿生长发育的调节因素之一; 2）内皮细胞功能参与了改变胎儿-胎盘循环血管阻力的机制。

项目成果

K.Tsukimori,H.Maeda,M.Shingu,T.Koyanagi,M.Nobunaga,H.Nakano.: "Possible mechanism of vascular damage in pre-eclampsia." J.Hum.Hypertension.8. 177-180 (1994)

K.Tsukimori、H.Maeda、M.Shingu、T.Koyanagi、M.Nobunaga、H.Nakano.：“先兆子痫血管损伤的可能机制。”

K.Sakai, H.Maeda, K.Tsukimori, H.Nagata, T.Koyanagi, H.Nakano: "How blood viscosity influences changes in circulation during pregnancy?" Fukuoka Acta Med.83. 328-332 (1992)

K.Sakai、H.Maeda、K.Tsukimori、H.Nagata、T.Koyanagi、H.Nakano：“血液粘度如何影响怀孕期间的循环变化？”

H.Maeda,T.Koyanagi,H.Nakano.: "Intrauterine treatment on non-immune hydrops fetalis" Early Hum.Dev.29. 241-249 (1992)

H.Maeda、T.Koyanagi、H.Nakano.：“非免疫性胎儿水肿的宫内治疗”Early Hum.Dev.29。

H.Maeda, T.Koyanagi、H.Nakano: "Intrauterine treatment on non-immune hydrops fetalis." Early Hum.Dev.29. 241-249 (1992)

H.Maeda、T.Koyanagi、H.Nakano：“非免疫性胎儿水肿的宫内治疗”。Dev.29 (1992)。

K.Tsukimori, H.Maeda, K.Ishida, H.Nagata, T.Koyanagi, H.Nakano: "The superoxide generation of neutrophils in normal and preeclamptic pregnancies." Obstet.Gynecol.81. 536-540 (1993)

K.Tsukimori、H.Maeda、K.Ishida、H.Nagata、T.Koyanagi、H.Nakano：“正常和先兆子痫妊娠中中性粒细胞的超氧化物生成。”