Oncogene and apoptosis related gene expression and radiation therapy respones of cervical cancer

宫颈癌癌基因和凋亡相关基因表达及放射治疗反应

基本信息

  • 批准号:
    06670945
  • 负责人:
  • 金额:
    $ 1.34万
  • 依托单位:
  • 依托单位国家:
    日本
  • 项目类别:
    Grant-in-Aid for General Scientific Research (C)
  • 财政年份:
    1994
  • 资助国家:
    日本
  • 起止时间:
    1994 至 1995
  • 项目状态:
    已结题

项目摘要

Correlations between radiation response and varios biological parameters including growth fraction, cell cycle factors, oncogene, apoptosis relating gene expression of tumors and histologic features were investigated for prediction of local control probability following radiation therapy.Immunohistochemical study was performed on 64 cervical cancer patients treated with radiation therapy.Prognosis was analyzed by c-erbB-2 oncoprotein expression (CerbB-OE), p53 protein expression, growth fraction detemined with Ki-67 immunohistochemistry (Ki-GF) and the mitotic index of proliferating cell population (pMI).The 5-year survival rates for the Ki-GF of 33% or greater were significantly better than those below 33% (87.5% vs 44.7%, P<0.01).The difference was due to difference in recurrence rates. The 5-year survival rates for patients with pMI of 3.5% or greater were significantly lower than those below 3.5% (0% vs 81.8%, P<0.001).The difference was due also to difference in recurrence rates.C … More erbB-OE was observed on the cell membrane of cancer cells.There was no significant correlation between p53 expression and survival.Positivity of CerbB-OE,which was 42.4% in total, increased significantly with stage progression.Mean Ki-GF and pMI were 36% and 2.5% in total, respectively.Mean Ki-GF for CerbB(+) Patients was 26.2%, significantly lower than the 38.3% for CerbB (-) patients (P<0.01).The mean pMI for CerbB (+) patients was 3.70%, significantly higher than the 2.00% of CerbB (-) patients (P<0.05).The correlation between CerbB-OE and Ki-GF and pM1 suggests that CerbB oncoprotein may play an important role in cell proliferation status of cancer of the uterine cervix. The 5-year survival rates of CerbB (+) and CerbB (-) patients were 45.1% and 75.6%, respectively, indicating that CerbB (+) patients showed significantly poorer survival than CerbB (-) ones (P<0.01).The difference in survival was mainly due to local recurrence rather than distant metastasis.The Ki-GF,pMI and CerbB-OE are suggested as significant predictor to local control as well as long term survival.Theses predictors are hopeful as determinants for selecting optimal therapeutic modalities. Less
研究放射反应与各种生物学参数(包括肿瘤生长分数、细胞周期因子、癌基因、凋亡相关基因表达和组织学特征)之间的相关性,以预测放射治疗后的局部控制概率。对64例接受放射治疗的宫颈癌患者进行免疫组化研究。通过c-erbB-2癌蛋白表达分析预后 (CerbB-OE)、p53蛋白表达、Ki-67免疫组化(Ki-GF)测定生长分数和增殖细胞群有丝分裂指数(pMI)。Ki-GF≥33%的5年生存率显着优于33%以下者(87.5% vs 44.7%, P<0.01)。差异是由于复发率差异所致。 pMI≥3.5%的患者5年生存率显着低于3.5%以下的患者(0% vs 81.8%,P<0.001)。这种差异也是由于复发率的差异所致。在癌细胞的细胞膜上观察到erbB-OE,p53的表达与生存率没有显着相关性。CerbB-OE的阳性率为42.4%,增加 平均Ki-GF和pMI总计分别为36%和2.5%。CerbB(+)患者的平均Ki-GF为26.2%,显着低于CerbB(-)患者的38.3%(P<0.01)。CerbB(+)患者的平均pMI为3.70%,显着高于CerbB的2.00% (-) 患者 (P<0.05)。 CerbB-OE与Ki-GF和pM1之间的相关性表明CerbB癌蛋白可能在宫颈癌的细胞增殖状态中发挥重要作用。 CerbB(+)和CerbB(-)患者的5年生存率分别为45.1%和75.6%,表明CerbB(+)患者的生存率明显低于CerbB(-)患者(P<0.01)。生存率差异主要是由于局部复发而不是远处转移。Ki-GF、pMI和CerbB-OE被认为是局部控制和预后的显着预测因子。 long term survival.Theses predictors are hopeful as determinants for selecting optimal therapeutic modalities.较少的

项目成果

期刊论文数量(50)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Nakano, T. ,: "Immunohistrochemical prediction of radiation response and local control in radiation therapy for cervical cancer." Clinical Immunol Imunopathol.(in press).
Nakano, T.:“宫颈癌放射治疗中放射反应的免疫组织化学预测和局部控制。”
  • DOI:
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    0
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  • 通讯作者:
NAKANO.T.: "Radiation therapy for adenocarcinoma of the Uterine ceruix" Int.J.Radiat.Oncol.Biol,Pbys.(in press). (1995)
NAKANO.T.:“宫颈腺癌的放射治疗”Int.J.Radiat.Oncol.Biol,Pbys.(印刷中)。
  • DOI:
  • 发表时间:
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    0
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  • 通讯作者:
Nakano, T: "Expression of proliferation-associated antigens in cervical carcinoma : Correlations among various indexes." Path. Res. Pract.191. 997-1003 (1995)
Nakano,T:“宫颈癌中增殖相关抗原的表达:各种指标之间的相关性。”
  • DOI:
  • 发表时间:
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  • 影响因子:
    0
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  • 通讯作者:
Oka, K., Nakano, T., Hoshi, T.: "Comparative analysis of response to radiation in cervical adenocarcinomaa and squamous cell carcinomas : MIBI and PC10 labeling indexes." Cancer. (IN PRESS).
Oka, K.、Nakano, T.、Hoshi, T.:“宫颈腺癌和鳞状细胞癌放射反应的比较分析:MIBI 和 PC10 标记指数。”
  • DOI:
  • 发表时间:
  • 期刊:
  • 影响因子:
    0
  • 作者:
  • 通讯作者:
Nakano, T.,: "Radiation therapy alone for adenocarcinoma of the uterine cervix." Int. J. Radiat. Oncol. Phys.32. 1333-1336 (1995)
Nakano, T.:“仅采用放射治疗治疗宫颈腺癌。”
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NAKANO Takashi其他文献

慢性拘束ストレス後の中脳中心灰白質におけるGFAPおよびglutamate transporterの減少
慢性束缚应激后中脑灰质中央 GFAP 和谷氨酸转运蛋白减少
  • DOI:
  • 发表时间:
  • 期刊:
  • 影响因子:
    0
  • 作者:
    OHMICHI Yusuke;OHMICHI Mika;SAKURAI Hiroki ;NAKANO Takashi;ASAMOTO Ken;USHIDA Takahiro;SATO Jun;井辺弘樹
  • 通讯作者:
    井辺弘樹

NAKANO Takashi的其他文献

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{{ truncateString('NAKANO Takashi', 18)}}的其他基金

Supply Platform of Short-lived Radioisotopes
短寿命放射性同位素供应平台
  • 批准号:
    16H06278
  • 财政年份:
    2019
  • 资助金额:
    $ 1.34万
  • 项目类别:
    Grant-in-Aid for Scientific Research on Innovative Areas ― Platforms for Advanced Technologies and Research Resources
Development of High Intensity Laser-Electron Photon beam with synchronized laser injection
同步激光注入高强度激光电子光子束的开发
  • 批准号:
    16K13806
  • 财政年份:
    2016
  • 资助金额:
    $ 1.34万
  • 项目类别:
    Grant-in-Aid for Challenging Exploratory Research
Basic research on Sophistication of Medical Si/CdTe compton camera
医用Si/CdTe康普顿相机精密度基础研究
  • 批准号:
    24659557
  • 财政年份:
    2012
  • 资助金额:
    $ 1.34万
  • 项目类别:
    Grant-in-Aid for Challenging Exploratory Research
Development and evaluation of a novel method for inactivation of clinical wastewater based on electrolysis
基于电解的临床废水灭活新方法的开发和评价
  • 批准号:
    22510091
  • 财政年份:
    2010
  • 资助金额:
    $ 1.34万
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
Management of environment to secure the quality of educators in the introduction of the new-curriculum
新课改环境管理确保教育工作者素质
  • 批准号:
    21592730
  • 财政年份:
    2009
  • 资助金额:
    $ 1.34万
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
Translational research for establishment of heavy ion radiotherapy for cancer
建立癌症重离子放射治疗的转化研究
  • 批准号:
    20390324
  • 财政年份:
    2008
  • 资助金额:
    $ 1.34万
  • 项目类别:
    Grant-in-Aid for Scientific Research (B)
Research on the driving, lubrication and self assembled mechanism of bacterial flagellar motor
细菌鞭毛马达驱动、润滑及自组装机制研究
  • 批准号:
    17560115
  • 财政年份:
    2005
  • 资助金额:
    $ 1.34万
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
Study of Exotic Baryon with High Intensity Photon Beam
高强度光子束研究奇异重子
  • 批准号:
    17070004
  • 财政年份:
    2005
  • 资助金额:
    $ 1.34万
  • 项目类别:
    Grant-in-Aid for Scientific Research on Priority Areas
Study of reaction mechanism of Theta+photo-production
Theta光产生反应机理研究
  • 批准号:
    16204017
  • 财政年份:
    2004
  • 资助金额:
    $ 1.34万
  • 项目类别:
    Grant-in-Aid for Scientific Research (A)
Modification of radiation sensitivity in radiation therapy by combination of molecular target therapy
结合分子靶向治疗改变放射治疗的放射敏感性
  • 批准号:
    16390334
  • 财政年份:
    2004
  • 资助金额:
    $ 1.34万
  • 项目类别:
    Grant-in-Aid for Scientific Research (B)

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  • 批准号:
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Nannocystin Reagents to Elucidate the Role of Elongation Factor 1a in Apoptosis
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