STUDIES ON THE DRUG DELIVERY SYSTEM FOR VITREO-RETINAL DISEASE

目的：针对复杂性玻璃体视网膜病变的治疗存在诸多局限性，在药物治疗方面提出了几点想法并进行了临床试验。药物释放系统(DDS)也已应用于眼科领域。材料和方法：将柔红霉素包裹于空脂质体中，注入正常及实验性PVR兔的玻璃体腔内。结果：与未用柔红霉素脂质体治疗的PVR相比，DDS治疗PVR的发生率较低。结论：注射乳化脂质体溶液对视网膜的可见度有一定的影响，但DDS有可能应用于PVR的治疗，避免玻璃体手术。

Purpose : As there are many limitations in treating complex vitreoretinopathy, several ideas and clinical trial has been made in terms of drug therapy. Drug delivery system(DDS)has been applied for ophthalmic field as well. The purpose of this study is to demonstrate the possibility of the system for treatment of refractive proliferative vitreoretinopathy(PVR).Materials and Methods : Daunorubicin was encapsulated in the empty liposome and injected into the vitreous cavity of pigmented rabbits both in normal as well as in experimental PVR.Results : As compared to the not treated eyes with Daunorubicin encapsulated liposome, series of PVR eyes treated with the DDS demonstrated the lower incidence of PVR.Conclusion : Although the injection of emulsified liposome solution interfered the visibility of the retina a little, it seems to be logical to assume that the DDS has possibility to apply for the treatment of PVR avoiding vitreous surgery.