Analysis of the function of Oncostatain M in chronic hepatitis andliver fibrosis
Analysis of the function of Oncostatain M in chronic hepatitis andliver fibrosis
批准号:
19590383
负责人:
TANAKA Minoru
金额:
$2.91万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2007
资助国家:
日本
项目状态:
已结题
起止时间:
2007 至 2008
中文摘要
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英文摘要
肝障害時におけるオンコスタチンM(OSM)の作用機序の解明を目指した。高脂肪食投与による肥満モデルでは、OSM 受容体KO マウスは野生型マウスに比べて有意に体重の増加を示し、肝臓内の脂質量が増加するなど、早期の脂肪肝を引き起こした。OSM はPPARg の発現を抑制することで脂肪肝を抑制していることが示唆された。また、肝炎惹起因子を投与したKO マウスは野生型マウスより感受性が高く、急性肝炎で死亡したことから、OSM には免疫抑制作用があることが示唆された。
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YB-1 downregulates expression of carbamoyl phosphate synthetase-I by suppressine C/EBPaloha function in mice.
YB-1 通过抑制小鼠中的 C/EBPaloha 功能来下调氨基甲酰磷酸合成酶-I 的表达。
DOI:
--
发表时间:
2009
期刊:
Gastroenterology (掲載確定 In press)
影响因子:
--
作者:
[Chen YR, Sekine K, Nakamura K, Yanai H. Tanaka M, Miyajima A.]
通讯作者:
Miyajima A.
DOI:
10.1002/dvdy.21227
发表时间:
2007-08-01
期刊:
DEVELOPMENTAL DYNAMICS
影响因子:
2.5
作者:
[Nonaka, Hidenori, Tanaka, Minoru, Miyajima, Atsushi]
通讯作者:
Miyajima, Atsushi
Oncostatin M receptor-beta signaling limits monocytic cell recruitment in acute inflammation
制瘤素 M 受体-β 信号传导限制急性炎症中单核细胞的募集
DOI:
--
发表时间:
2008
期刊:
Journal of Immunology 181
影响因子:
--
作者:
[Hams E, Colmont CS, Dioszeghy V, Hammond VJ, Fielding CA, Williams AS, Tanaka M, Miyajima A, Taylor PR, Torley N, Jones SA.]
通讯作者:
Jones SA.
肝幹細胞の分離と性状解析
肝干细胞的分离和表征
DOI:
--
发表时间:
2008
期刊:
影响因子:
--
作者:
[田中稔, 河村由布子, 岡部繭子, 鈴木香, 斎藤滋, 宮島篤]
通讯作者:
宮島篤
抗p75NTR 抗体を用いた胎生肝臓における間葉系前駆細胞の分離
使用抗 p75NTR 抗体分离胚胎肝脏中的间充质祖细胞
DOI:
--
发表时间:
2007
期刊:
影响因子:
--
作者:
[Hamada T, Sato A, Hirano T, Yamamoto T, Son G, Onodera M, Torii I, Nishigami T, Tanaka M, Miyajima A, Nishiguchi S, Fujimoto J, Tsujimura T., 田中稔, 田中稔, 田中稔]
通讯作者:
田中稔
共 17 条
Functional analysis of liver stem/progenitor cell in liver regeneration and carcinogenesis
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批准号:25670187
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项目类别:Grant-in-Aid for Challenging Exploratory Research
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资助金额:$2.5万
-
财政年份:2013
-
负责人:TANAKA Minoru
-
依托单位:
Analyses of Mechanisms in Early Gametogenesis
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批准号:25251034
-
项目类别:Grant-in-Aid for Scientific Research (A)
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资助金额:$29.7万
-
财政年份:2013
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负责人:TANAKA Minoru
-
依托单位:
Analysis of cell-cell interaction among hepatic non-parenchymal
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批准号:22590719
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.91万
-
财政年份:2010
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负责人:TANAKA Minoru
-
依托单位:
Analysis of Sexual Plasticity in Gonads by AMH System
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批准号:21370101
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$12.06万
-
财政年份:2009
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负责人:TANAKA Minoru
-
依托单位:
Dendritic cell therapy using propagative herpes simplex virus for malignant brain tumors
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批准号:19591662
-
项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$2.16万
-
财政年份:2007
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负责人:TANAKA Minoru
-
依托单位:
Phenotypic Analyses and Identification of Causal Mutations In Medaka Mutants with Gonadal Dysgenesis.
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批准号:17370083
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项目类别:Grant-in-Aid for Scientific Research (B)
-
资助金额:$8.13万
-
财政年份:2005
-
负责人:TANAKA Minoru
-
依托单位:
Basic research for antitumor immune response induced by dendritic cells pulsed with lysate of HSV-1-infected tumor cells
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批准号:17591501
-
项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$1.98万
-
财政年份:2005
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负责人:TANAKA Minoru
-
依托单位:
Basic study for application of stress-resistant effect of prolactin to animals
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批准号:15380203
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$5.89万
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财政年份:2003
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负责人:TANAKA Minoru
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依托单位:
Investigation for Common Molecular Mechanisms by Comparison of EST from Purified Germ Cells
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批准号:15310133
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项目类别:Grant-in-Aid for Scientific Research (B)
-
资助金额:$8.83万
-
财政年份:2003
-
负责人:TANAKA Minoru
-
依托单位:
Exploring supersymmetry and its breaking with flavor physics
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批准号:15540272
-
项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$2.24万
-
财政年份:2003
-
负责人:TANAKA Minoru
-
依托单位:
Development of efficient pretreatment method for analyzing polar compound using solid-phase derivatization
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批准号:15550070
-
项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$1.66万
-
财政年份:2003
-
负责人:TANAKA Minoru
-
依托单位:
The research of the behavior of geodesics
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批准号:14540091
-
项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$1.79万
-
财政年份:2002
-
负责人:TANAKA Minoru
-
依托单位:
Mechanism of prolactin action on induction of development, enlargement and inflammation of prostate -study with prolactin knockout mice-
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批准号:13670136
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项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$1.73万
-
财政年份:2001
-
负责人:TANAKA Minoru
-
依托单位:
The elucidation of the molecule mechanism of the drug susceptibility in the chemotherapy for the oligodendroglioma
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批准号:13470284
-
项目类别:Grant-in-Aid for Scientific Research (B)
-
资助金额:$8.77万
-
财政年份:2001
-
负责人:TANAKA Minoru
-
依托单位:
High density mapping of BAC end sequences onto medaka linkage groups
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批准号:11236210
-
项目类别:Grant-in-Aid for Scientific Research on Priority Areas
-
资助金额:$125.7万
-
财政年份:1999
-
负责人:TANAKA Minoru
-
依托单位:
A Study of Disaster Prevention of Earthquake in Science Education
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批准号:09680237
-
项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$1.09万
-
财政年份:1997
-
负责人:TANAKA Minoru
-
依托单位:
Study on molecular mechanism for regulation of maternal behavior with prolactin-knockout mice
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批准号:09680791
-
项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$1.79万
-
财政年份:1997
-
负责人:TANAKA Minoru
-
依托单位:
Study of Extension of Functions of Iconic Workspace
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批准号:08680437
-
项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$0.38万
-
财政年份:1996
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负责人:TANAKA Minoru
-
依托单位:
Studies on the Development of Selectively Modified Cyclodextrin Stationary Phases for HPLC
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批准号:07555568
-
项目类别:Grant-in-Aid for Scientific Research (A)
-
资助金额:$1.6万
-
财政年份:1995
-
负责人:TANAKA Minoru
-
依托单位:
STUDIES ON THE DRUG DELIVERY SYSTEM FOR VITREO-RETINAL DISEASE
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批准号:06671774
-
项目类别:Grant-in-Aid for General Scientific Research (C)
-
资助金额:$1.15万
-
财政年份:1994
-
负责人:TANAKA Minoru
-
依托单位:
海外基金