Analysis of cell-cell interaction among hepatic non-parenchymal
Analysis of cell-cell interaction among hepatic non-parenchymal
批准号:
22590719
负责人:
TANAKA Minoru
金额:
$2.91万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2010
资助国家:
日本
项目状态:
已结题
起止时间:
2010 至 2012
中文摘要
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英文摘要
Hepatic sinusoid is composed of stellate cells (HSCs) and sinusoidalendothelial cells. In this study, we focused on cell-cell interaction between HSCs and theother non-parenchymal cells (NPCs) at liver fibrosis. We found that Oncostatin M (OSM)directly induced TIMP-1 expression in HSCs and contributed to liver fibrosis bysuppressing the digestion of collagen fiber. Furthermore, OSM seemed to induce theactivation of HSCs indirectly via NPCs. Finally, overexpression of OSM in liver resulted infibrosis without apparent hepatic injury.
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マーカー分子による肝幹/前駆細胞の性状解析
使用标记分子对肝干/祖细胞进行特征分析
DOI:
--
发表时间:
2012
期刊:
影响因子:
--
作者:
[Kanda Y, Abo T, Ohkoshi S, 田中稔]
通讯作者:
田中稔
オンコスタチンMはマクロファージのM1/M2バランスに作用しインスリン抵抗性を改善する 発表者
制瘤素 M 影响巨噬细胞 M1/M2 平衡并改善胰岛素抵抗 Presenter
DOI:
--
发表时间:
2012
期刊:
影响因子:
--
作者:
[Fujimaki S, Matsuda Y, Wakai T, Sanpei A, Kubota M, Takamura M, Yamagiwa S, Yano M, Ohkoshi S, Aoyagi Y, 田中稔]
通讯作者:
田中稔
Identification of fetal liver cellscontributing to hematopoiesis duringmouse embryogenesis
小鼠胚胎发生过程中促进造血的胎儿肝细胞的鉴定
DOI:
--
发表时间:
2010
期刊:
影响因子:
--
作者:
[Aoki YH, Ohkoshi S, Yamagiwa S, Yano M, Takahashi H, Waguri N, Igarashi K, Sugitani S, Takahashi T, Ishikawa T, Kamimura T, Wakabayashi H, Watanabe T, Matsuda Y,(2)Nomoto M, Aoyagi Y, 田中稔]
通讯作者:
田中稔
非アルコール性脂肪肝炎モデル非ヒト哺乳動物及びその作製方法
非酒精性脂肪性肝炎模型非人哺乳动物及其制备方法
DOI:
--
发表时间:
2012
期刊:
影响因子:
--
作者:
[]
通讯作者:
オンコスタチンMはマクロファージのM1/M2バランスに作用しインスリン抵抗性を改善する
制瘤素M影响巨噬细胞M1/M2平衡,改善胰岛素抵抗
DOI:
--
发表时间:
2012
期刊:
影响因子:
--
作者:
[田中稔, 小森 忠祐, 森川吉博, 仙波恵美子, 宮島篤]
通讯作者:
宮島篤
共 18 条
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Basic study for application of stress-resistant effect of prolactin to animals
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Investigation for Common Molecular Mechanisms by Comparison of EST from Purified Germ Cells
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Exploring supersymmetry and its breaking with flavor physics
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Development of efficient pretreatment method for analyzing polar compound using solid-phase derivatization
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The elucidation of the molecule mechanism of the drug susceptibility in the chemotherapy for the oligodendroglioma
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High density mapping of BAC end sequences onto medaka linkage groups
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A Study of Disaster Prevention of Earthquake in Science Education
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Study on molecular mechanism for regulation of maternal behavior with prolactin-knockout mice
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Study of Extension of Functions of Iconic Workspace
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Studies on the Development of Selectively Modified Cyclodextrin Stationary Phases for HPLC
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海外基金