Neuro-theoretical analysis of brain rhythmic information in cognitive and verbal behavior

认知和言语行为中大脑节律信息的神经理论分析

• 批准号: 06680846
• 负责人: ITOH Kenji
• 金额: $ 1.47万
• 依托单位: University of Tokyo
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for General Scientific Research (C)
• 财政年份: 1994
• 资助国家: 日本
• 起止时间: 1994 至 1995
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-06680846/
• 关键词: EEG rhythm; Neural circuits; Alpha wave; Synaptic potential; CSD; Neurotransmitter; Fractal analysis; Eye movements; 誘発電位

We investigated and got following results on the relationship between human cognitive/verbal process and brain rhythmic information.1.For analyzing generation of cognition-/language-related rhythmic activities based on neurosynaptic circuits, we modeled and simulated neurosynaptic circuits of sensory area-thalamus and hippocampus-septum as bi-directional cortico-subcortical system.2.For developing a method of time series analysis of single-trial rhythmic information from EEG/MEG,we modified and integrated 2D-spline interpolation and adaptive correlation filter with templates to complete an algorithm of extracting a single-trial rhythmic bursts as well as of estimating source localization to be presented in 3D brain image.3.For establishing a testing method of brain rhythmic information in cognitive/verbal behavior, we analyzed characteristics of rhythmic structure with fractals etc.in the cognitive and verbal data acquired by EEG/MEG system as well as eyetracker.4.For invetigating relationships between cognitive/verbal rhythmic information and neurotransmitter/modulator metabolites, we analyzed plasma metabolites as well as brain rhythmic activities during cognitive/verbal tasks to investigate the constructed model.5.For modeling of rhythmic activities in cognitive/verbal disorders, we developed the circuit model to propose a model of neural information processing explaining the relations among deficits in cognitive/verbal behavior, in neurotransmitter/modulator metabolites and in EEG/MEG as well as eye movements.

我们对人类认知/言语过程与大脑节奏信息的关系进行了调查，得到了以下结果。为了分析基于神经突触回路的认知/语言相关节律活动的产生，我们将感觉区-丘脑和海马-隔的神经突触回路作为皮质-皮质下双向系统进行建模和模拟。为了建立一种对脑电/脑磁图单次节律信息进行时间序列分析的方法，我们将二维样条插值和自适应相关滤波器与模板进行改进和集成，完成了一种提取单次节律爆发的算法，并估计了三维脑图像中呈现的源定位。为了建立认知/言语行为中脑节奏信息的测试方法，我们用分形等方法分析了脑电/脑磁图系统和眼动仪采集的认知和言语数据的节奏结构特征。为了研究认知/言语节奏信息与神经递质/调节剂代谢物之间的关系，我们分析了认知/言语任务期间的血浆代谢物以及大脑节奏活动来验证所构建的模型。对于认知/语言障碍的节律性活动建模，我们开发了电路模型，提出了一个神经信息处理模型，解释认知/语言行为、神经递质/调节剂代谢物、脑电图/MEG和眼动缺陷之间的关系。

项目成果

Mazuka R, Itoh K, et al: "Reanalysis that is not costly and non reanalysis that is costly in Japanese: Eye Movement Study" Proceedings of 1996 Meeting of the CUNY. (in press). (1996)

Mazuka R、Itoh K 等人：“日语中不昂贵的重新分析和昂贵的非重新分析：眼动研究”1996 年纽约市立大学会议记录。

Kenji ITOH: "A Neurosynaptic model of state-dependent EEG wave generation in subcortico-cortical system" IEEE Transactions on Biomedical Engineering. 41. 954-962 (1994)

Kenji ITOH：“皮质下皮质系统中状态依赖的 EEG 波生成的神经突触模型”IEEE 生物医学工程汇刊。

鶴紀子,丹羽真一,伊藤憲治,他: "事象関連電位:事象関連電位と神経情報科学の発展" 新興医学出版(印刷中), (1996)

Noriko Tsuru、Shinichi Niwa、Kenji Ito 等：“事件相关电位：事件相关电位和神经信息学的发展”Shinko Igaku Shuppan（出版中），（1996 年）

Mazuka R,Itoh K,et al: "Reanalysis that is not costly and non renalysis that is costly in Japanese : eye movement study" Proc 1996 Meeting of the CUNY. (in press). (1996)

Mazuka R、Itoh K 等人：“日语中成本不高的再分析和成本高昂的非肾分析：眼动研究”Proc 1996 纽约市立大学会议。

伊藤憲治,越田一郎,平松謙一,他: "対話と思考過程における脳内律動情報処理機構のモデル" 1996年電子情報通信学会総合大会講演論文集(基礎・境界). (印刷中). (1996)

Kenji Ito、Ichiro Koshida、Kenichi Hiramatsu 等人：“对话和思维过程中大脑节奏信息处理机制的模型”1996 年 IEICE 大会论文集（基础与边界）（1996 年出版）。