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Development of analyzing and imaging system of three-dimensional brain functional mapping for diagnosis and treatment evaluation of language and cognitive disorders

三维脑功能图分析成像系统开发，用于语言和认知障碍的诊断和治疗评估

基本信息

批准号：
06558120
负责人：
ITOH Kenji
金额：
$ 1.02万
依托单位：
University of Tokyo
依托单位国家：
日本
项目类别：
Grant-in-Aid for Developmental Scientific Research (B)
财政年份：
1994
资助国家：
日本
起止时间：
1994 至 1995
项目状态：
已结题

项目摘要

We investigated and got following results on the development of analyzing and imaging system of three-dimensional brain functional mapping for diagnosis and treatment evaluation of language and cognitive disorders.1.For developing a method of three-dimensional brain functional localization based on neurosynaptic circuit model, we tried three-dimensional functional localization by use of a scalp current density method on spherical cortex in the cortico-subcortical model.2.For developing a testing paradigm of functional localization in verbal and cognitive deficits, we implemented a program of instructing strategies on paradigms for verbal and cognitive functions.3.For establishing a evaluation method of treatment as well as rehabilitation of verbal and cognitive deficits, we proposed a method of subjective evaluation on instructed learning and drug treatment based on their data base.4.For establishing a method of diagnosis with brain functional localization, we proposed a method of diagnosis using a interactive system of navigating images in archives of MRI/fMRI 3D tomographic data, EEG spherical topography, and MEG current source.5.For developing a routine of analyzing and imaging 3D brain functional localization, we completed a program of analyzing and imaging pictures from data objects in object-oriented programming language (C^<++>).6.For applying the analyzing and imaging system of three-dimensional brain functional mapping to clinical use, we completed the system of multi-channel data input system with analyzing system of 3D brain functional localization.

本论文对用于语言和认知障碍诊断和治疗评价的三维脑功能图分析成像系统的研制进行了研究，取得了以下成果：1.建立了基于神经突触回路模型的三维脑功能定位方法，我们尝试通过使用头皮电流密度方法在皮质中的球形皮质上进行三维功能定位，2.为建立言语和认知功能障碍的功能定位测试范式，我们实施了言语和认知功能范式指导策略计划。3.为建立言语和认知功能障碍治疗和康复的评估方法，提出了基于指导学习和药物治疗数据库的主观评价方法。4.建立脑功能定位诊断方法，我们提出了一种诊断方法，该方法使用在MRI/fMRI 3D断层扫描数据、EEG球形地形图和MEG电流源的档案中导航图像的交互式系统。5.为了开发分析和成像3D脑功能定位的例程，6.为了将三维脑功能图分析成像系统应用于临床，我们完成了多通道数据输入系统和三维脑功能定位分析系统的设计。