Development of evaluation and diagnostic method on integration and its disorders of mental and language functions by analysis of synchronous oscillations in brain

通过分析大脑同步振荡来开发精神和语言功能整合及其障碍的评估和诊断方法

• 批准号: 15500312
• 负责人: ITOH Kenji
• 金额: $ 2.37万
• 依托单位: The University of Tokyo
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2003
• 资助国家: 日本
• 起止时间: 2003 至 2004
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-15500312/
• 关键词: personality; high-density EEG and MEG; high-frequency oscillation; spectral analysis; social skill training; cognitive and language disorder; empathy; diagnostic speech; 高密度脳波; コヒーレンス; 認知障害; ジェスチャー; 対話

We aimed to develop an evaluation and diagnostic method with behavioral as well as brain imaging and functional data on integration and its disorders of mental, language and music functions in normal, musicians and schizophrenics on the basis of the binding problem in distributed inter-/intra-hemispheric synchronous system related to personal ability and creativity in higher cognitive and verbal communications.1.We investigated the algorism of extracting effective brain event-related potentials and oscillations, as well as their correlation analysis for specifying personal ability, mental as well as language disorders based on the cortico-subcortical system.2.We extended the method of correlation analysis by including brain morphological data and personal rating on verbal and cognitive abilities.3.We made verbal as well as music sound and graphic files for audio-visual tasks of new mismatch negativity paradigm.4.We improved the integrated database system on mental and language disorders.5.We tried to apply the system to evaluate mental and language disorders, training effectiveness as well as to establish individual training programBy introducing the knowledge on quantitative test for cognitive and verbal disorders, we confirmed the clinical applicability of the system.

本研究针对认知和言语交际中与个人能力和创造力相关的分布式大脑半球间/大脑内同步系统的绑定问题，提出了一种基于行为、脑成像和功能数据对正常人、音乐家和精神分裂症患者的心理、语言和音乐功能整合及其障碍的评估和诊断方法。1.研究了提取有效的脑事件相关电位和振荡的算法及其相关性分析，以确定个人的能力。2.扩展了相关分析的方法，包括大脑形态数据和个人对言语和认知能力的评分。3.为新的失配否定范式的视听任务制作了语音和音乐声像文件。4.完善了心理和语言障碍综合数据库系统。5.尝试将该系统应用于心理和语言障碍的评估、训练效果以及制定个性化训练方案。通过引入认知和语言障碍定量测试的知识，验证了该系统的临床适用性。

项目成果

A modified parallel paradigm for clinical evaluation of auditory echoic memory

听觉回声记忆临床评估的改进并行范例

• 发表时间: 2005
• 期刊: NeuroReport 16
• 作者: Karino S;Yumoto M;Itoh K;Yamakawa K;Mizuochi T;Kaga K
• 通讯作者: Kaga K

Spatiotemporal neuromagnetic activities during pitch processing in musicians.

音乐家音高处理过程中的时空神经磁活动。

• 发表时间: 2005
• 期刊: NeuroReport 16 (in press)
• 作者: Yumoto M;Uno A;Itoh K;Matuda M;Karino S;Kaga K
• 通讯作者: Kaga K

Brain electric activity for active inhibition of auditory irrelevant information.

脑电活动主动抑制听觉无关信息。

• 发表时间: 2005
• 期刊: Neuroscience Letters 374
• 作者: Araki T;Kasai K;Nakagome K;Fukuda M;Itoh K;Iwanami A
• 通讯作者: Iwanami A

A modified parallel paradigm for clinical evaluation of auditory echoic memory.

听觉回声记忆临床评估的改进并行范例。

• 发表时间: 2005
• 期刊: NeuroReport 16
• 作者: Karino S;Yumoto M;Itoh K;Yamakawa K;Mizuochi T;Kaga K
• 通讯作者: Kaga K

狩野章太郎, 湯本真人, 伊藤憲治, 宇野彰, 加我君孝, 他: "Binaural Beatに誘発される脳磁場活動"電子情報通信学会技術研究報告. 103・307. 11-14 (2003)

Shotaro Kano、Masato Yumoto、Kenji Ito、Akira Uno、Kimitaka Kaga 等：“双耳节拍引起的脑磁场活动”IEICE 11-14 (2003)。