Studies on the transmission and pathobiology of New and Old World leishmaniases

新旧大陆利什曼病的传播和病理学研究

• 批准号: 18256004
• 负责人: HASHIGUCHI Yoshihisa
• 金额: $ 27.21万
• 依托单位: Kochi University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (A)
• 财政年份: 2006
• 资助国家: 日本
• 起止时间: 2006 至 2009
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-18256004/
• 关键词: 国際交流研究; エクアドル:ペルー:アルゼンチン:パキスタン:バングラデシュ; リーシュマニア症; 媒介サシチョウバエ; 伝播疫学; 分子生物学; 病態生理; Leishmania原虫感染; 国際研究者交流; エクアドル:ペルー:パキスタン:バングラデシュ; サシチョウバエ; リーシュマニア原虫; LAMP法; エクアドル; ペルー; アルゼンチン; パキスタン; バングラデシュ; ウタ症; バルトネラ症; アマスチゴート抗原; ONO-4007

Leishmaniasis is one of the protozoan infectious diseases transmitted by blood-sucking insects, sandflies. The disease is widely distributed, affecting at least 12 million people in 88 countries of the world. In this study, three disease factors, patients, vector sandflies, and reservoir animals, were investigated by employing molecular biological, immunological and epidemiological methods. Main results obtained are as follows : (1) relation between Leishmania spp. and disease forms, (2) determination of vector species, (3) search for different mammals infected with Leishmania, (4) development of rapid diagnosis and treatment, (5) search for control measures at each endemic area.

利什曼病是一种由吸血昆虫白蛉传播的原生动物传染病。这种疾病分布广泛，影响到世界88个国家至少1 200万人。本研究采用分子生物学、免疫学和流行病学方法对患者、媒介白蛉和宿主动物3个致病因素进行调查。取得的主要成果有：(1)利什曼原虫与疾病形式的关系；(2)媒介种类的确定；(3)寻找感染利什曼原虫的不同哺乳动物；(4)发展快速诊断和治疗；(5)在各流行区寻找控制措施。

项目成果

Natural infection of the sand fly Phlebotomus kazeruni by Trypanosoma species in Pakistan

• DOI: 10.1186/1756-3305-3-10
• 发表时间: 2010-02-25
• 期刊: PARASITES & VECTORS
• 影响因子: 3.2
• 作者: Kato, Hirotomo;Uezato, Hiroshi;Hashiguchi, Yoshihisa
• 通讯作者: Hashiguchi, Yoshihisa

Phylogenic analysis of the genus Leishmania by cytochrome b gene sequencing

• DOI: 10.1016/j.exppara.2008.12.013
• 发表时间: 2009-04-01
• 期刊: EXPERIMENTAL PARASITOLOGY
• 影响因子: 2.1
• 作者: Asato, Yutaka;Oshiro, Minoru;Uezato, Hiroshi
• 通讯作者: Uezato, Hiroshi

Establishment of a mass screening method of sand fly vectors for Leishmania infection by molecular biological methods

• DOI: 10.4269/ajtmh.2007.77.324
• 发表时间: 2007-08-01
• 期刊: AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE
• 影响因子: 3.3
• 作者: Kato, Hirotomo;Uezato, Hiroshi;Hashiguchi, Yoshihisa
• 通讯作者: Hashiguchi, Yoshihisa

Establishment of a Mass Screening Method of Sand Fly Vectors for Leishmania Infection by Molecular Biological Method

分子生物学方法建立利什曼原虫感染白蛉载体大规模筛查方法

• 发表时间: 2007
• 期刊: Am.J.Trop.Med.Hyg 77
• 作者: Hirotomo Kato;et. al.
• 通讯作者: et. al.

Leishmania isoenzyme polymorphisms in Ecuador:: Relationships with geographic distribution and clinical presentation

• DOI: 10.1186/1471-2334-6-139
• 发表时间: 2006-09-13
• 期刊: BMC INFECTIOUS DISEASES
• 影响因子: 3.7
• 作者: Calvopina, Manuel;Armijos, Rodrigo X.;Hashiguchi, Yoshihisa
• 通讯作者: Hashiguchi, Yoshihisa