Phytochemical genomics : Genomic basis for phytochemical diversity

植物化学基因组学：植物化学多样性的基因组基础

• 批准号: 19201043
• 负责人: SAITO Kazuki
• 金额: $ 29.37万
• 依托单位: Chiba University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (A)
• 财政年份: 2007
• 资助国家: 日本
• 起止时间: 2007 至 2010
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-19201043/
• 关键词: 植物成分; 二次代謝産物; メタボロミクス; トランスクリプトミクス; ゲノム機能学; 生合成; フラボノイド; シロイヌナズナ; 薬用植物; アルカロイド; システイン; ゲノム機能科学

Plants produce over 200,000 chemical compounds, which are used as the sources of medicines, foods, industrial and energy materials in our daily life. In this project, we have investigated the genomic basis for the production of these plant products by means of metabolomics and transcriptomics. We have identified genes involved in the production of flavonoids, sulfur-containing metabolites and alkaloids, which exhibit health-beneficial activities. We have also elucidated the metabolic networks for the production of these compounds.

植物产生超过20万种化合物，这些化合物在我们的日常生活中被用作药物、食品、工业和能源材料的来源。在本项目中，我们通过代谢组学和转录组学研究了这些植物产品产生的基因组基础。我们已经确定了与黄酮类化合物、含硫代谢物和生物碱产生有关的基因，这些基因具有有益健康的活性。我们还阐明了这些化合物产生的代谢网络。

项目成果

Transport of camptothecin in hairy roots of Ophiorrhiza pumila.

• DOI: 10.1016/j.phytochem.2007.08.028
• 发表时间: 2007-11
• 期刊: Phytochemistry
• 影响因子: 3.8
• 作者: S. Sirikantaramas;H. Sudo;T. Asano;M. Yamazaki;K. Saito

Mutations in topoisomerase I as a self-resistance mechanism coevolved with the production of the anticancer alkaloid camptothecin in plants

• DOI: 10.1073/pnas.0801038105
• 发表时间: 2008-05-06
• 期刊: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
• 影响因子: 11.1
• 作者: Sirikantaramas, Supaart;Yamazaki, Mami;Saito, Kazuki
• 通讯作者: Saito, Kazuki

Metabolomics-oriented isolation and structure elucidation of 37 compounds including two new anthocyanins from Arabidopsis thaliana

拟南芥中 37 种化合物（包括两种新花青素）的代谢组学分离和结构解析

• 发表时间: 2009
• 期刊: Phytochemistry 70
• 作者: Ryo Nakabayashi;Miyako Kusano;Makoto Kobayashi;Takayuki Tohge;Keiko Yonekura-Sakakibara;Noriyuki Kogure;Mami Yamazaki;Mariko Kitajima;Kazuki Saito;Hiromitsu Takayama
• 通讯作者: Hiromitsu Takayama

An acyltransferase-like gene obtained by differential gene expression profiles of quinolizidine alkaloid-producing and nonproducing cultivars of Lupinus angustifolius

• DOI: 10.5511/plantbiotechnology.10.1109b
• 发表时间: 2011-01-01
• 期刊: PLANT BIOTECHNOLOGY
• 影响因子: 1.6
• 作者: Bunsupa, Somnuk;Okada, Taketo;Yamazaki, Mami
• 通讯作者: Yamazaki, Mami

Phytochemical genomics in Arabidopsis thaliana and towards non-model plants. Integration of metabolomics and transcriptomics.

拟南芥和非模式植物的植物化学基因组学。

• 发表时间: 2007
• 作者: Kawabe;H. and K. Kamae;Michiko Kimoto;崔吉城;Toru Onozawa;斉藤和季
• 通讯作者: 斉藤和季