Preparation and Utilization of Functional Conjugate Containing Salmon Milt DNA

DNA是生命过程中最重要的物质之一，是一种天然存在的、高度特异性的功能性生物聚合物，但它具有水溶性和生物化学不稳定性。这些弱点必须加以改善，以利用DNA。我们已经制备了各种DNA材料与其他生物聚合物，如海藻酸或胶原蛋白，或紫外线诱导交联反应的共轭。这些含有DNA的材料是水不溶性的，并且仍然保留天然DNA的特异性功能。因此，这些材料可用于生物医学和环境领域，制备用于外科手术的DNA-壳聚糖双层膜和DNA-胶原纤维膜，以及用于积累环境激素的水不溶性DNA膜。

DNA, one of the most inportant materials for life processes, can be regarded as a naturally occurring and highly specific functional biopolymer.However, DNA is water-soluble and biochemically unstable. These weak points have to be improved for the utilization of DNA. We have prepared various DNA-materials by conjugation with other biopolymer, such as alginic acid or collagen, or UV-induced cross-linking reaction. These DNA containing materials were water-insolubilized and still retained the specific function of native DNA. Thus, these materials could be used in biomedical and also environmental field, preparing the DNA-chitosan bilayer membrane and DNA-collagen fibrous membrane for surgical use and also water-insoluble DNA film to accumulate environmental hormone.