Joint Research on Preparation of Novel Bioconjugates

近年来，核酸（DNA和RNA）、多肽、蛋白质、多糖、脂质等生物相关高分子材料的研究得到了广泛的发展。然而，这些材料的研究领域各不相同，相互间的交流与合作还不多见。在它们的场之间或它们的共轭场中会发现非常精细的功能材料。本课题旨在通过与日本和德国的研究人员就各种生物相关聚合物的接触讨论和合作，制备新型生物偶联物，为此，开展了以下研究工作.医用DNA-壳聚糖双层膜的制备.糖肽和糖蛋白合成的基础研究.紫外线照射对DNA的不溶解作用。DNA-胶原生物缀合物的制备。

Research on bio-related polymeric materials, such as nucleic acid(DNA and RNA), peptide, protein, polysaccharide, lipid, has developed extensively in resent years. However, the each research fields for these materials have their own world, and their mutual exchange and colaborations are not popular so far. Very fine functional materials would be found between their field or in their conjugated fields. We intended to prepare novel bioconjugate by the contact discussion and colaboration of Japanese and German researchers on various biorelated polymers.As a result, following researches have been carried out.1. Preparation of DNA-chitosan bilayer membrane for surgecal use.2. Basic research on syntehsis of glycopeptide and glycoprotein.3. Insolubilization of DNA by UV-irradiation.4. Preparation of DNA-collagen bioconjugate.