Preparation of Nucleic Acid-Biopolymer Composites with Regular Structure

规则结构核酸-生物聚合物复合材料的制备

• 批准号: 13132201
• 负责人: NISHI Norio
• 金额: $ 23.55万
• 依托单位: HOKKAIDO UNIVERSITY
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research on Priority Areas
• 财政年份: 2001
• 资助国家: 日本
• 起止时间: 2001 至 2004
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-13132201/
• 关键词: nucleic acid; DNA; biopolymer; regular structure composite; DNA-collagen composite; DNA-synthetic polymer composite; DNA-metal composite; DNA-silica composite; DNA-コラーゲンコンポジット; DNA-シリカコンポジット; DNA-高分子複合ゲル; ダイオキシン誘導体; DNA-金属コンポジット; DNA-イオン性液体コン

Following DNA-containing composites were prepared to find the functional materials with novel functions caused by the DNA structure.1. DNA-collagen composites. (1)salmon sperm DNA-collagen composite (2) plasmid DNA-collagen composite2. DNA-synthetic polymer composites. (1)DNA-polyacrylmnide composite (2)interpenetrate network of DNA-polyvinyl alcohol composite.3. DNA-metal composites. (1)DNA-Cu^<2+> composite (2)DNA-Al^<3+> composite4. DNA-silica composite by sol-gel method.5. DNA composites with ion conductivity.These DNA-containing composites would have possibilities to be used in various fields as sophisticated functional materials such as medical polymers, separating devices for the DNA-binding materials and ion conductive materials.

制备了含DNA的复合材料，以寻找由DNA结构引起的新功能材料. DNA-胶原复合物。（1）鲑鱼精DNA-胶原复合物（2）质粒DNA-胶原复合物2. DNA合成聚合物复合材料。（1）DNA-聚丙烯酰胺复合材料（2）DNA-聚乙烯醇互穿网络复合材料. DNA-金属复合物。（1）DNA-Cu^<2+>复合材料（2）DNA-Al^<3+>复合材料4.溶胶-凝胶法制备DNA-二氧化硅复合材料.具有离子导电性的DNA复合材料，这些含DNA的复合材料将有可能作为复杂的功能材料应用于各个领域，如医用聚合物、DNA结合材料的分离装置和离子导电材料。

项目成果

Masanori Yamada: "UV-Irradiated DNA Matrixes Selectively Bind Endocrine Disruptors with a Planar Structure"Environ. Sci. & Technol.. 36. 949-954 (2002)

Masanori Yamada：“紫外线照射的 DNA 基质通过平面结构选择性地结合内分泌干扰物”环境。

西 則雄: "ぼくもノーベル賞をとるぞ"高分子学会出版部. 175 (2001)

西纪夫：“我也会获得诺贝尔奖”高分子科学学会出版部175（2001）。

C.S.Zhao: "Blood Compatible Aspects of DNA-Modified Polysulfone Membrane, Protein Adsorption and Platelet Adhesion"Biomaterials. 24. 3747-3755 (2003)

C.S.Zhao：“DNA修饰的聚砜膜的血液相容性、蛋白质吸附和血小板粘附”生物材料。

Effect of DNA structure on the formation of collagen-DNA complex

• DOI: 10.1016/j.ijbiomac.2004.11.005
• 发表时间: 2005-03-01
• 期刊: INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
• 影响因子: 8.2
• 作者: Kaya, M;Toyama, Y;Nishi, N
• 通讯作者: Nishi, N

Isao Ohiso: "Conformational Study of the Tandem Repeat Sequence in RNA Polymerase II by Circular Dichroism Spectroscopy"Bull.Chem.Soc.Jpn.. 74. 1139-1143 (2001)

Isao Ohiso：“通过圆二色光谱法对 RNA 聚合酶 II 中串联重复序列的构象研究”Bull.Chem.Soc.Jpn.. 74. 1139-1143 (2001)