Synthesis of Sequential Polypeptides Having Biological Activity

具有生物活性的序列多肽的合成

• 批准号: 61550668
• 负责人: NISHI Norio
• 金额: $ 1.41万
• 依托单位: Hokkaido University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for General Scientific Research (C)
• 财政年份: 1986
• 资助国家: 日本
• 起止时间: 1986 至 1987
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-61550668/
• 关键词: Diphenylphosphoryl Azide(DPPA); Polymerization; Sequential Polypeptides; Conformation; Biopolymers; DNA; 精子特異性塩基性タンパク質; DNA凝集能; DNA結合塩基性タンパク質

Recently, we found the new synthetic method of polypeptides to employ diphenylphosphoryl azide(DPPA) as a polymerization reagent. This method is adequate for the polymerization of peptides to give protein-like sequentialpolypeptides. In the present investigation, various types of biologically active sequential polypeptides were prepared, and their conformation and the interactions with biopolymers such as DNA were investigated to clarify their possibility as biofunctional materials. The medical application of these sequential polypeptides were also examined.

近年来，我们发现了一种新的多肽合成方法，即以叠氮磷酸二苯酯（DPPA）为聚合试剂。这种方法适用于多肽聚合，得到蛋白质样序列多肽。在本研究中，制备了各种类型的具有生物活性的序列多肽，并研究了它们的构象以及与生物聚合物如DNA的相互作用，以阐明它们作为生物功能材料的可能性。这些序列多肽的医学应用也进行了检查。

项目成果

Hiroyuki Yamamoto: "Chiral interaction of sequential lysine polypeptides with methyl orange. Effects of distance between lysine residues and hydrophobic side chains." Colloid & Polymer Sci.264. 779-785 (1986)

Hiroyuki Yamamoto：“连续赖氨酸多肽与甲基橙的手性相互作用。赖氨酸残基和疏水侧链之间距离的影响。”

Norio Nishi: Petide Chem.1985. 245-250 (1986)

西纪男：Petide Chem.1985。

Norio Nishi: Rept.Progr.Polym.Phys.Jpn.29. 681-684 (1986)

西纪夫：Rept.Progr.Polym.Phys.Jpn.29。

Hiroyuki Yamamoto: Colloid&Polymer Sci.264. 779-785 (1986)

山本宏之：胶体

Norio Nishi: Rept.Progr.Polym.Phys.Jap.29. 681-684 (1986)

西纪夫：Rept.Progr.Polym.Phys.Jap.29。