Synthesis of Sequential Polypeptides Having Biological Activity

近年来，我们发现了一种新的多肽合成方法，即以叠氮磷酸二苯酯（DPPA）为聚合试剂。这种方法适用于多肽聚合，得到蛋白质样序列多肽。在本研究中，制备了各种类型的具有生物活性的序列多肽，并研究了它们的构象以及与生物聚合物如DNA的相互作用，以阐明它们作为生物功能材料的可能性。这些序列多肽的医学应用也进行了检查。

Recently, we found the new synthetic method of polypeptides to employ diphenylphosphoryl azide(DPPA) as a polymerization reagent. This method is adequate for the polymerization of peptides to give protein-like sequentialpolypeptides. In the present investigation, various types of biologically active sequential polypeptides were prepared, and their conformation and the interactions with biopolymers such as DNA were investigated to clarify their possibility as biofunctional materials. The medical application of these sequential polypeptides were also examined.