PREPARATION OF NOVEL HEMOCOMPATIBLE HOLLOW FIBER MEMBRANE AND DEVICE FOR SAFETY BLOOD PURIFICATION HOME

新型血液相容性中空纤维膜及安全血液净化装置的制备

基本信息

  • 批准号:
    10558131
  • 负责人:
  • 金额:
    $ 4.29万
  • 依托单位:
  • 依托单位国家:
    日本
  • 项目类别:
    Grant-in-Aid for Scientific Research (B)
  • 财政年份:
    1998
  • 资助国家:
    日本
  • 起止时间:
    1998 至 2001
  • 项目状态:
    已结题

项目摘要

Blood compatible hollow fibers were prepared from a polymer alloy composed of polysulfone(PSf) and 2-methacryloyloxyethyl phosphorylcholine (MPC) polymer. To improve hydorophilicity, non-fouling characteristics, and blood compatibility of the PSf hollow fiber in a hemodialyzer, we synthesized a MPC polymer which can be blended with PSf for preparing the polymer alloy (PSf/MPC polymer). The content of the MPC polymer blended in the PSf was 7 and 15 wt%. The PSf/MPC polymer hollow fiber could be prepared by both wet and dry-wet processing methods. The hollow fiber took an asymmetric structure and its mechanical strength was enough for practical use for hemodialysis. The surface characterization of the PSf/MPC polymer hollow fiber by X-ray photoelectron spectroscopy revealed that the MPC unit were concentrated PSf/MPC polymer hollow fiber was higher and the amount of protein absorbed on the PSf/MPC polymer hollow fiber was lower than those of the PSf hollow fiber Moreover, platelet adhesion was also effectively inhibited on the PSf/MPC polymer hollow fiber. Based on these results, the addition of the MPC polymer to the PSf is a very useful method to improve the functions and blood compatibility of the hollow fiber . From the PSf/MPC polymer hollow fibers, the mini-module for hemodialysis was prepared . Preliminary animal experiments demonstrated that it had excellent antithrombogenic property and permeability for solute during the experiment even when any anticoagulant PSf/MPC polymer is provided to the medical device production company in Japan and new blood purification device is under developing.
以聚砜(PSf)和2-甲基丙烯酰氧乙基磷酰胆碱(MPC)聚合物为原料,制备了血液相容性中空纤维。为了改善血液透析器中PSf中空纤维的亲水性、无污染特性和血液相容性,我们合成了MPC聚合物,其可以与PSf共混以制备聚合物合金(PSf/MPC聚合物)。在PSf中共混的MPC聚合物的含量为7和15重量%。PSf/MPC聚合物中空纤维可通过湿法和干湿法制备。中空纤维呈非对称结构,其机械强度足以用于血液透析。通过X射线光电子能谱对PSf/MPC聚合物中空纤维的表面进行表征,结果表明:与PSf中空纤维相比,PSf/MPC聚合物中空纤维上MPC单元更集中,蛋白质吸附量更低,而且PSf/MPC聚合物中空纤维还能有效地抑制血小板的粘附。基于这些结果,将MPC聚合物添加到PSf中是改善中空纤维的功能和血液相容性的非常有用的方法。利用PSf/MPC聚合物中空纤维制备了用于血液透析的微型模块。初步的动物实验表明,即使向日本的医疗器械生产公司提供任何抗凝剂PSf/MPC聚合物,并且正在开发新的血液净化装置,在实验期间,它也具有优异的抗血栓形成性能和对溶质的渗透性。

项目成果

期刊论文数量(53)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Kazuhiko Ishihara et al.: "Improvement of Blood Compatibility on Cellulose Hemodialysis Membrane : IV. Phospholipid Polymer Bonded to the Membrane Surface"J. Biomater. Sci. Polymer Edn.. 10. 271-282 (1999)
Kazuhiko Ishihara 等人:“纤维素血液透析膜上血液相容性的改善:IV. 结合到膜表面的磷脂聚合物”J。
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    0
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K. ISHIHARA, K. FUKUMOTO, Y IWASAKI, N. NAKABAYASHI: "MODIFICATION OF POLYSULFONE WITH PHOSPHOLIPID POLYMER FOR IMPROVEMENT OF THE BLOOD COMPATIBILITY. PART 1. - SURFACE CHARACTERIZATION"BIOMATERIALS. 20. 1545-1551 (1999)
K. ISHIHARA、K. FUKUMOTO、Y IWASAKI、N. Nakabayashi:“用磷脂聚合物对聚砜进行改性以改善血液相容性。第 1 部分 - 表面表征”生物材料。
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    0
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H KAWANO, K. KURITA, Y IWASAKI, N. NAKABAYASHI, K. ISHIHARA: "SURFACE GRAFTING OF PHOSPHOLIPID POLYMER ON CELLULOSE MEMBRANE FOR IMPROVING HEMOCOMPATIBILITY"REP. PROG. POLYM.PHYS. JPN. 41. 305-308 (1998)
H KAWANO、K. KURITA、Y IWASAKI、N. Nakabayashi、K. Ishihara:“在纤维素膜上表面接枝磷脂聚合物以改善血液相容性”REP。
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  • 影响因子:
    0
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  • 通讯作者:
Takashi Hasegawa, et al.: "Preparation and Performance of Protein Adsorption Resistance Asymmetric Porous Membrane by Polysulfone/Phospholipid Polymer Blend"Biomaterials. 22. 243-251 (2001)
Takashi Hasekawa 等人:“聚砜/磷脂聚合物共混物的蛋白质吸附抗性不对称多孔膜的制备和性能”生物材料。
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  • 影响因子:
    0
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  • 通讯作者:
Takashi Hasegawa et al.: "Preparation and Performance of Protein Adsorptlon Resistance Asymmetric Porous Membrane by Po1ystdfone/Phoapholupid Polymer Blend"Biomaterials. 22. 243-251 (2001)
Takashi Hasekawa 等人:“Po1ystdfone/Phoapholupid 聚合物混合物的抗蛋白质吸附不对称多孔膜的制备和性能”生物材料。
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    0
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ISHIHARA Kazuhiko其他文献

Synthesis of Thereto-Responsive Hydrogel Cross-Linked by Gold Nano Collaid
金纳米胶交联响应性水凝胶的合成
  • DOI:
  • 发表时间:
    2010
  • 期刊:
  • 影响因子:
    0
  • 作者:
    GOTO Fumi;YUSA Shin-ichi;MORISHIMA Yotaro;ISHIHARA Kazuhiko
  • 通讯作者:
    ISHIHARA Kazuhiko

ISHIHARA Kazuhiko的其他文献

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{{ truncateString('ISHIHARA Kazuhiko', 18)}}的其他基金

Preparation of cell-based electron-generator
细胞电子发生器的制备
  • 批准号:
    22650107
  • 财政年份:
    2010
  • 资助金额:
    $ 4.29万
  • 项目类别:
    Grant-in-Aid for Challenging Exploratory Research
Preparation of biocompatible polymer nanoparticles as cell-function analysis biodevices
作为细胞功能分析生物器件的生物相容性聚合物纳米颗粒的制备
  • 批准号:
    21300176
  • 财政年份:
    2009
  • 资助金额:
    $ 4.29万
  • 项目类别:
    Grant-in-Aid for Scientific Research (B)
Study on a formulation of housing policy vision by character of area and renewal policy in suburb from view point of shrinking city
收缩城市视角下分区特征住房政策愿景制定及郊区更新政策研究
  • 批准号:
    18600009
  • 财政年份:
    2006
  • 资助金额:
    $ 4.29万
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
DETERMINATION OF MECHANISM FOR MOLECULAR ADHESION TO SOFT TISSUES AND MATERALS PREPARATION
软组织分子粘附机制的测定及材料制备
  • 批准号:
    17300144
  • 财政年份:
    2005
  • 资助金额:
    $ 4.29万
  • 项目类别:
    Grant-in-Aid for Scientific Research (B)
Function of gastro-intestinal mucin-derived acidic oligosaccharaides recognized by anti-mucin monoclonal antibodies
抗粘蛋白单克隆抗体识别的胃肠粘蛋白衍生酸性寡糖的功能
  • 批准号:
    16590629
  • 财政年份:
    2004
  • 资助金额:
    $ 4.29万
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
Structure Control and Functions of Biocompatible Polymer Alloy as Biomaterials
生物相容性聚合物合金作为生物材料的结构控制和功能
  • 批准号:
    13480288
  • 财政年份:
    2001
  • 资助金额:
    $ 4.29万
  • 项目类别:
    Grant-in-Aid for Scientific Research (B)
A systematic development of monoclonal antibodies against mucins of digestive tract and their application to pathophysiological studies
抗消化道粘蛋白单克隆抗体的系统开发及其在病理生理学研究中的应用
  • 批准号:
    12670514
  • 财政年份:
    2000
  • 资助金额:
    $ 4.29万
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
PREPARATION OF NOVEL BIOMEDICAL POLYMERS HAUING BIOMEMBRANE-LIKE SURFACE AND RECOGNITION OF THEIR NON THROMBOGENIC
具有类生物膜表面的新型生物医用聚合物的制备及其非血栓形成的识别
  • 批准号:
    09480250
  • 财政年份:
    1997
  • 资助金额:
    $ 4.29万
  • 项目类别:
    Grant-in-Aid for Scientific Research (B).
Mucus secretion studies using anti-gastric mucin monoclonal antibodies
使用抗胃粘蛋白单克隆抗体进行粘液分泌研究
  • 批准号:
    07670612
  • 财政年份:
    1995
  • 资助金额:
    $ 4.29万
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
Preparation of Novel Biocompatible polymeric Additives and Modification of Biomedical Materials Using the Additives
新型生物相容性高分子添加剂的制备及其对生物医用材料的改性
  • 批准号:
    07680934
  • 财政年份:
    1995
  • 资助金额:
    $ 4.29万
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
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