PREPARATION OF NOVEL HEMOCOMPATIBLE HOLLOW FIBER MEMBRANE AND DEVICE FOR SAFETY BLOOD PURIFICATION HOME

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Blood compatible hollow fibers were prepared from a polymer alloy composed of polysulfone(PSf) and 2-methacryloyloxyethyl phosphorylcholine (MPC) polymer. To improve hydorophilicity, non-fouling characteristics, and blood compatibility of the PSf hollow fiber in a hemodialyzer, we synthesized a MPC polymer which can be blended with PSf for preparing the polymer alloy (PSf/MPC polymer). The content of the MPC polymer blended in the PSf was 7 and 15 wt%. The PSf/MPC polymer hollow fiber could be prepared by both wet and dry-wet processing methods. The hollow fiber took an asymmetric structure and its mechanical strength was enough for practical use for hemodialysis. The surface characterization of the PSf/MPC polymer hollow fiber by X-ray photoelectron spectroscopy revealed that the MPC unit were concentrated PSf/MPC polymer hollow fiber was higher and the amount of protein absorbed on the PSf/MPC polymer hollow fiber was lower than those of the PSf hollow fiber Moreover, platelet adhesion was also effectively inhibited on the PSf/MPC polymer hollow fiber. Based on these results, the addition of the MPC polymer to the PSf is a very useful method to improve the functions and blood compatibility of the hollow fiber . From the PSf/MPC polymer hollow fibers, the mini-module for hemodialysis was prepared . Preliminary animal experiments demonstrated that it had excellent antithrombogenic property and permeability for solute during the experiment even when any anticoagulant PSf/MPC polymer is provided to the medical device production company in Japan and new blood purification device is under developing.