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PREPARATION OF NOVEL HEMOCOMPATIBLE HOLLOW FIBER MEMBRANE AND DEVICE FOR SAFETY BLOOD PURIFICATION HOME

新型血液相容性中空纤维膜及安全血液净化装置的制备

基本信息

批准号：
10558131
负责人：
ISHIHARA Kazuhiko
金额：
$ 4.29万
依托单位：
THE UNIVERSITY OF TOKYO
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (B)
财政年份：
1998
资助国家：
日本
起止时间：
1998 至 2001
项目状态：
已结题

项目摘要

Blood compatible hollow fibers were prepared from a polymer alloy composed of polysulfone(PSf) and 2-methacryloyloxyethyl phosphorylcholine (MPC) polymer. To improve hydorophilicity, non-fouling characteristics, and blood compatibility of the PSf hollow fiber in a hemodialyzer, we synthesized a MPC polymer which can be blended with PSf for preparing the polymer alloy (PSf/MPC polymer). The content of the MPC polymer blended in the PSf was 7 and 15 wt%. The PSf/MPC polymer hollow fiber could be prepared by both wet and dry-wet processing methods. The hollow fiber took an asymmetric structure and its mechanical strength was enough for practical use for hemodialysis. The surface characterization of the PSf/MPC polymer hollow fiber by X-ray photoelectron spectroscopy revealed that the MPC unit were concentrated PSf/MPC polymer hollow fiber was higher and the amount of protein absorbed on the PSf/MPC polymer hollow fiber was lower than those of the PSf hollow fiber Moreover, platelet adhesion was also effectively inhibited on the PSf/MPC polymer hollow fiber. Based on these results, the addition of the MPC polymer to the PSf is a very useful method to improve the functions and blood compatibility of the hollow fiber . From the PSf/MPC polymer hollow fibers, the mini-module for hemodialysis was prepared . Preliminary animal experiments demonstrated that it had excellent antithrombogenic property and permeability for solute during the experiment even when any anticoagulant PSf/MPC polymer is provided to the medical device production company in Japan and new blood purification device is under developing.

以聚砜（PSf）和2-甲基丙烯酰氧乙基磷酰胆碱（MPC）聚合物为原料，制备了血液相容性中空纤维。为了改善血液透析器中PSf中空纤维的亲水性、无污染特性和血液相容性，我们合成了MPC聚合物，其可以与PSf共混以制备聚合物合金（PSf/MPC聚合物）。在PSf中共混的MPC聚合物的含量为7和15重量%。PSf/MPC聚合物中空纤维可通过湿法和干湿法制备。中空纤维呈非对称结构，其机械强度足以用于血液透析。通过X射线光电子能谱对PSf/MPC聚合物中空纤维的表面进行表征，结果表明：与PSf中空纤维相比，PSf/MPC聚合物中空纤维上MPC单元更集中，蛋白质吸附量更低，而且PSf/MPC聚合物中空纤维还能有效地抑制血小板的粘附。基于这些结果，将MPC聚合物添加到PSf中是改善中空纤维的功能和血液相容性的非常有用的方法。利用PSf/MPC聚合物中空纤维制备了用于血液透析的微型模块。初步的动物实验表明，即使向日本的医疗器械生产公司提供任何抗凝剂PSf/MPC聚合物，并且正在开发新的血液净化装置，在实验期间，它也具有优异的抗血栓形成性能和对溶质的渗透性。