DETERMINATION OF MECHANISM FOR MOLECULAR ADHESION TO SOFT TISSUES AND MATERALS PREPARATION

软组织分子粘附机制的测定及材料制备

基本信息

  • 批准号:
    17300144
  • 负责人:
  • 金额:
    $ 9.98万
  • 依托单位:
  • 依托单位国家:
    日本
  • 项目类别:
    Grant-in-Aid for Scientific Research (B)
  • 财政年份:
    2005
  • 资助国家:
    日本
  • 起止时间:
    2005 至 2007
  • 项目状态:
    已结题

项目摘要

In this study the polymer structures were determined to adhere the polymer to tissues. The molecular design of the polymers were carried out with attention to the regulation of cell/materials interactions from of the physical chemistry and the biological both sides. The polymers could easily solidify themselves by the phase transition of the polymers and voluntary organization as far the normal temperature and to realize the adhesion prescribed it. It prescribed the molecular structure of this polymers closely and composed it, and the wound produced the soft tissue adhesion materials of the prototype than adhesion performance and examination of the safety.A thought prepared nanoparticles as a probe for recognizing the specific reaction analytical technique that I found so far; and to prescribe the functional group, which could adhere for a cell, the structure of the ligand molecule. At first the functional groups with various hydrophobicity, electric charge, hydrogen bonding connected to use physicochemical interaction. The water-soluble phospholipid polymers, which did immobilization of the specific functional group was used for surface treatment materials and the polymer solution for making an O/W emulsion and manufactured nanoparticles.The functional groups cold introduce with high-density for suitable interaction with cells. The adhesion of cells and tissues could be achieved. To determine the structure and composition bonded this polymer to the cells, which became single-layered and examined the reply of the cell As well as a form, the number of the increases, the intracellular enzyme activity was measured to consider in particular cell activity It prescribed polymer composition, the chemical structure that did not affect a cell than these. On the other hand, a molecule design about the polymers was carries out to reduce adhesive property and performed examination form the viewpoint of prevention of organization adhesion.
在这项研究中,确定了聚合物的结构,以将聚合物附着到组织上。聚合物的分子设计从物理化学和生物两方面考虑了细胞/材料相互作用的调节。聚合物在常温下容易通过聚合物的相变和自组织而固化,并实现所规定的粘附性。它紧密地规定了这种聚合物的分子结构并组成了它,并在伤口处产生了软组织黏附材料的原型,通过对黏附性能和安全性的检查。一种思想制备了纳米颗粒作为探针,用于识别我迄今所发现的特定的反应分析技术;并规定了可以黏附于细胞的官能团、配体分子结构。首先将具有不同疏水性、电荷、氢键的官能团通过物理化学反应连接起来。将固定特定官能团的水溶性磷脂聚合物作为表面处理材料和制备O/W乳状液的聚合物溶液,制成纳米粒子,引入密度高的官能团,与细胞进行适当的相互作用。可以实现细胞与组织的黏附。为了确定这种聚合物结合到细胞上的结构和组成,细胞变成单层,并检查细胞的应答以及形式、增加的数量,测量细胞内酶活性,以特别考虑它规定的聚合物组成的细胞活性,即不影响细胞的化学结构。另一方面,对聚合物进行了降低粘接性能的分子设计,并从防止组织粘连的角度进行了检验。

项目成果

期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
pH応答性ポリマー鎖によるナノ粒子界面でのバイオ反応の制御
使用 pH 响应聚合物链控制纳米颗粒界面的生物反应
  • DOI:
  • 发表时间:
    2006
  • 期刊:
  • 影响因子:
    0
  • 作者:
    伊藤 智美;渡邉 順司;高井 まどか;石原 一彦
  • 通讯作者:
    石原 一彦
Controlling bio-reaction on the interface of the nanoparticles by response polymer chain
通过响应聚合物链控制纳米粒子界面上的生物反应
  • DOI:
  • 发表时间:
    2005
  • 期刊:
  • 影响因子:
    0
  • 作者:
    T. Ito;J. Watanabe;M. Takai;K. Ishihara
  • 通讯作者:
    K. Ishihara
Adhesion to Cells of Enzyme Conjugated Phospholipid Polymer Nanoparticles
酶结合磷脂聚合物纳米粒子对细胞的粘附
Bioadhesion of polyion complex (PIC) hydrogels composed of amphiphilic phospholipid polymers
由两亲性磷脂聚合物组成的聚离子复合物(PIC)水凝胶的生物粘附
Construction of cell-reaction recognition biointerface
细胞反应识别生物界面的构建
  • DOI:
  • 发表时间:
    2005
  • 期刊:
  • 影响因子:
    0
  • 作者:
    T. Ito;T. Konno;M. Takai;K. Ishihara
  • 通讯作者:
    K. Ishihara
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ISHIHARA Kazuhiko其他文献

Synthesis of Thereto-Responsive Hydrogel Cross-Linked by Gold Nano Collaid
金纳米胶交联响应性水凝胶的合成
  • DOI:
  • 发表时间:
    2010
  • 期刊:
  • 影响因子:
    0
  • 作者:
    GOTO Fumi;YUSA Shin-ichi;MORISHIMA Yotaro;ISHIHARA Kazuhiko
  • 通讯作者:
    ISHIHARA Kazuhiko

ISHIHARA Kazuhiko的其他文献

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{{ truncateString('ISHIHARA Kazuhiko', 18)}}的其他基金

Preparation of cell-based electron-generator
细胞电子发生器的制备
  • 批准号:
    22650107
  • 财政年份:
    2010
  • 资助金额:
    $ 9.98万
  • 项目类别:
    Grant-in-Aid for Challenging Exploratory Research
Preparation of biocompatible polymer nanoparticles as cell-function analysis biodevices
作为细胞功能分析生物器件的生物相容性聚合物纳米颗粒的制备
  • 批准号:
    21300176
  • 财政年份:
    2009
  • 资助金额:
    $ 9.98万
  • 项目类别:
    Grant-in-Aid for Scientific Research (B)
Study on a formulation of housing policy vision by character of area and renewal policy in suburb from view point of shrinking city
收缩城市视角下分区特征住房政策愿景制定及郊区更新政策研究
  • 批准号:
    18600009
  • 财政年份:
    2006
  • 资助金额:
    $ 9.98万
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
Function of gastro-intestinal mucin-derived acidic oligosaccharaides recognized by anti-mucin monoclonal antibodies
抗粘蛋白单克隆抗体识别的胃肠粘蛋白衍生酸性寡糖的功能
  • 批准号:
    16590629
  • 财政年份:
    2004
  • 资助金额:
    $ 9.98万
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
Structure Control and Functions of Biocompatible Polymer Alloy as Biomaterials
生物相容性聚合物合金作为生物材料的结构控制和功能
  • 批准号:
    13480288
  • 财政年份:
    2001
  • 资助金额:
    $ 9.98万
  • 项目类别:
    Grant-in-Aid for Scientific Research (B)
A systematic development of monoclonal antibodies against mucins of digestive tract and their application to pathophysiological studies
抗消化道粘蛋白单克隆抗体的系统开发及其在病理生理学研究中的应用
  • 批准号:
    12670514
  • 财政年份:
    2000
  • 资助金额:
    $ 9.98万
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
PREPARATION OF NOVEL HEMOCOMPATIBLE HOLLOW FIBER MEMBRANE AND DEVICE FOR SAFETY BLOOD PURIFICATION HOME
新型血液相容性中空纤维膜及安全血液净化装置的制备
  • 批准号:
    10558131
  • 财政年份:
    1998
  • 资助金额:
    $ 9.98万
  • 项目类别:
    Grant-in-Aid for Scientific Research (B)
PREPARATION OF NOVEL BIOMEDICAL POLYMERS HAUING BIOMEMBRANE-LIKE SURFACE AND RECOGNITION OF THEIR NON THROMBOGENIC
具有类生物膜表面的新型生物医用聚合物的制备及其非血栓形成的识别
  • 批准号:
    09480250
  • 财政年份:
    1997
  • 资助金额:
    $ 9.98万
  • 项目类别:
    Grant-in-Aid for Scientific Research (B).
Mucus secretion studies using anti-gastric mucin monoclonal antibodies
使用抗胃粘蛋白单克隆抗体进行粘液分泌研究
  • 批准号:
    07670612
  • 财政年份:
    1995
  • 资助金额:
    $ 9.98万
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
Preparation of Novel Biocompatible polymeric Additives and Modification of Biomedical Materials Using the Additives
新型生物相容性高分子添加剂的制备及其对生物医用材料的改性
  • 批准号:
    07680934
  • 财政年份:
    1995
  • 资助金额:
    $ 9.98万
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)

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基于 iPSC 的无异源平台,用于评估新生物材料的异物反应
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