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PREPARATION OF NOVEL BIOMEDICAL POLYMERS HAUING BIOMEMBRANE-LIKE SURFACE AND RECOGNITION OF THEIR NON THROMBOGENIC

具有类生物膜表面的新型生物医用聚合物的制备及其非血栓形成的识别

基本信息

批准号：
09480250
负责人：
ISHIHARA Kazuhiko
金额：
$ 5.44万
依托单位：
THE UNIVERSITY OF TOKYO (1998-2000)Tokyo Medical and Dental University (1997)
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (B).
财政年份：
1997
资助国家：
日本
起止时间：
1997 至 2000
项目状态：
已结题

项目摘要

Novel polymer biomaterials, which can use in contact with blood, are prepared with strong inspiration from the surface structure of biomembrane. That is, the polymers with phospholipid polar group in the side chain, 2-methacrylooyloxyethyl phosphorylcholine (MPC) polymers were synthesized. The MPC polymers can inhibit surface-induced clot formation effectively, even when they contact with blood in the absence of anticoagulant. This phenomenon was due to reduction of plasma protein and suppression of denaturation of adsorbed proteins. That is, the MPC polymers interact with blood components very mildly.The amount of protein adsorbed on the polymer surface had a close relation to the free water fraction in the hydrated polymer. A comparison of the conformational change in proteins adsorbed on the MPC polymers and poly (HEMA) revealed that the effectiveness of the phosphorylcholine group in preventing the change, and the protein on the MPC polymer maintained its original state. Thus, it is concluded that the free water fraction is one of the most important factors in controlling the protein adsorption process.As the molecular structure of the MPC polymer was easily designed by changing monomer units and composition, it could apply to surface modification of artificial organs and biomedical devices for improving blood compatibility and tissue compatibility. Thus, the MPC polymers are useful polymer biomaterials for making high performance artificial organs and biomedical devices to provide safety medical treatments.

受生物膜表面结构的强烈启发，制备了新型的可与血液接触的高分子生物材料。合成了侧链含磷脂极性基团的聚合物2-甲基丙烯酰氧乙基磷酰胆碱（MPC）聚合物。MPC聚合物可以有效地抑制表面诱导的凝块形成，即使当它们在不存在抗凝剂的情况下与血液接触时。这一现象是由于血浆蛋白减少和吸附蛋白变性的抑制。MPC聚合物与血液成分的相互作用非常温和，聚合物表面蛋白质的吸附量与聚合物中自由水的含量密切相关。吸附在MPC聚合物和聚（HEMA）上的蛋白质的构象变化的比较表明，磷酸胆碱基团在防止变化的有效性，和MPC聚合物上的蛋白质保持其原始状态。因此，自由水含量是控制蛋白质吸附过程的重要因素之一，MPC聚合物的分子结构易于通过改变单体单元和组成进行设计，可应用于人工器官和生物医用器件的表面改性，以改善血液相容性和组织相容性。因此，MPC聚合物是用于制造高性能人工器官和生物医学装置以提供安全医学治疗的有用的聚合物生物材料。