PREPARATION OF NOVEL BIOMEDICAL POLYMERS HAUING BIOMEMBRANE-LIKE SURFACE AND RECOGNITION OF THEIR NON THROMBOGENIC

具有类生物膜表面的新型生物医用聚合物的制备及其非血栓形成的识别

基本信息

项目摘要

Novel polymer biomaterials, which can use in contact with blood, are prepared with strong inspiration from the surface structure of biomembrane. That is, the polymers with phospholipid polar group in the side chain, 2-methacrylooyloxyethyl phosphorylcholine (MPC) polymers were synthesized. The MPC polymers can inhibit surface-induced clot formation effectively, even when they contact with blood in the absence of anticoagulant. This phenomenon was due to reduction of plasma protein and suppression of denaturation of adsorbed proteins. That is, the MPC polymers interact with blood components very mildly.The amount of protein adsorbed on the polymer surface had a close relation to the free water fraction in the hydrated polymer. A comparison of the conformational change in proteins adsorbed on the MPC polymers and poly (HEMA) revealed that the effectiveness of the phosphorylcholine group in preventing the change, and the protein on the MPC polymer maintained its original state. Thus, it is concluded that the free water fraction is one of the most important factors in controlling the protein adsorption process.As the molecular structure of the MPC polymer was easily designed by changing monomer units and composition, it could apply to surface modification of artificial organs and biomedical devices for improving blood compatibility and tissue compatibility. Thus, the MPC polymers are useful polymer biomaterials for making high performance artificial organs and biomedical devices to provide safety medical treatments.
从生物膜的表面结构中获得强烈灵感,制备出可与血液接触的新型高分子生物材料。即合成了侧链上具有磷脂极性基团的聚合物- 2-甲基丙烯酰氧乙基磷酸胆碱(MPC)聚合物。即使在没有抗凝剂的情况下与血液接触,MPC聚合物也能有效地抑制表面诱导的血块形成。这种现象是由于血浆蛋白的减少和吸附蛋白变性的抑制。也就是说,MPC聚合物与血液成分的相互作用非常温和。蛋白质在聚合物表面的吸附量与水合聚合物中游离水的含量密切相关。比较了蛋白质吸附在MPC聚合物和聚HEMA上的构象变化,发现磷酸胆碱基团有效地阻止了这种变化,MPC聚合物上的蛋白质保持了原来的状态。由此可见,游离水分数是控制蛋白质吸附过程的重要因素之一。由于MPC聚合物的分子结构易于通过改变单体单元和组成进行设计,因此可以应用于人工器官和生物医学设备的表面修饰,以提高血液相容性和组织相容性。因此,MPC聚合物是一种有用的高分子生物材料,可用于制造高性能的人造器官和生物医学设备,以提供安全的医疗。

项目成果

期刊论文数量(20)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
K.Ishihara: "New Polymeric Biomaterials-Phospholopid Polymers with Biocompatible Surface"Frantiers Med,Biol.Engng. 10・2. 83-95 (2000)
K. Ishihara:“新型高分子生物材料-具有生物相容性表面的磷脂聚合物” Frantiers Med,Biol 10・2(2000)。
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K. Ishihara, E. Ishikawa, Y. Iwasaki, and N. Nakabayashi: "Inhibition of Cell Adhesion on the Substarate by Coating with 2-Methacryloyloxyethy1 Phosphorylcholine Polymers"J. Biomater. Sci., Polymer Edn.. 1010. 1047-1061 (1999)
K. Ishihara、E. Ishikawa、Y. Iwasaki 和 N. Nakabayashi:“通过涂覆 2-甲基丙烯酰氧基乙基 1 磷酸胆碱聚合物来抑制细胞在基质上的粘附”J。
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T.Yomeyama,M.Ito,Y.Iwasaki K.Ishihara,N.Nakabayashi: "Small-Diameter Vascular Prostheis with a Nonthrombogenic Phospholipid Polymer Surface"Artf.Organs. 24・1. 23-28 (2000)
T.Yomeyama、M.Ito、Y.Iwasaki K.Ishihara、N.Nakabayashi:“具有非血栓形成磷脂聚合物表面的小直径血管假体”Artf.Organs 24・1。
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K.Ishihara: "ADVANCES IN POLYMERIC BIOMATERIALS SCIENCE" T.Akaike, T.Okano, M.Akashi, M.Terano, N.Yui, 686 (1997)
K.Ishihara:“高分子生物材料科学的进展” T.Akaike、T.Okano、M.Akashi、M.Terano、N.Yui,686 (1997)
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Y. Iwasaki, S. Sawada, N. Nakabayashi, G. Khang, H. B. Lee and K. Ishihara: "The Effect of Chemical Structure of the Phospholipid Polymer on Fibronectin Adsorption and Fibroblast Adhesion on the Gradient Phospholipid Surface"Biomaterials. 20・22. 2185-2191
Y. Iwasaki、S. Sawada、N. Nakabayashi、G. Khang、H. B. Lee 和 K. Ishihara:“磷脂聚合物的化学结构对梯度磷脂表面上的纤连蛋白吸附和成纤维细胞粘附的影响”生物材料20・22。 .2185-2191
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ISHIHARA Kazuhiko其他文献

Synthesis of Thereto-Responsive Hydrogel Cross-Linked by Gold Nano Collaid
金纳米胶交联响应性水凝胶的合成
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    2010
  • 期刊:
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    0
  • 作者:
    GOTO Fumi;YUSA Shin-ichi;MORISHIMA Yotaro;ISHIHARA Kazuhiko
  • 通讯作者:
    ISHIHARA Kazuhiko

ISHIHARA Kazuhiko的其他文献

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{{ truncateString('ISHIHARA Kazuhiko', 18)}}的其他基金

Preparation of cell-based electron-generator
细胞电子发生器的制备
  • 批准号:
    22650107
  • 财政年份:
    2010
  • 资助金额:
    $ 5.44万
  • 项目类别:
    Grant-in-Aid for Challenging Exploratory Research
Preparation of biocompatible polymer nanoparticles as cell-function analysis biodevices
作为细胞功能分析生物器件的生物相容性聚合物纳米颗粒的制备
  • 批准号:
    21300176
  • 财政年份:
    2009
  • 资助金额:
    $ 5.44万
  • 项目类别:
    Grant-in-Aid for Scientific Research (B)
Study on a formulation of housing policy vision by character of area and renewal policy in suburb from view point of shrinking city
收缩城市视角下分区特征住房政策愿景制定及郊区更新政策研究
  • 批准号:
    18600009
  • 财政年份:
    2006
  • 资助金额:
    $ 5.44万
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
DETERMINATION OF MECHANISM FOR MOLECULAR ADHESION TO SOFT TISSUES AND MATERALS PREPARATION
软组织分子粘附机制的测定及材料制备
  • 批准号:
    17300144
  • 财政年份:
    2005
  • 资助金额:
    $ 5.44万
  • 项目类别:
    Grant-in-Aid for Scientific Research (B)
Function of gastro-intestinal mucin-derived acidic oligosaccharaides recognized by anti-mucin monoclonal antibodies
抗粘蛋白单克隆抗体识别的胃肠粘蛋白衍生酸性寡糖的功能
  • 批准号:
    16590629
  • 财政年份:
    2004
  • 资助金额:
    $ 5.44万
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
Structure Control and Functions of Biocompatible Polymer Alloy as Biomaterials
生物相容性聚合物合金作为生物材料的结构控制和功能
  • 批准号:
    13480288
  • 财政年份:
    2001
  • 资助金额:
    $ 5.44万
  • 项目类别:
    Grant-in-Aid for Scientific Research (B)
A systematic development of monoclonal antibodies against mucins of digestive tract and their application to pathophysiological studies
抗消化道粘蛋白单克隆抗体的系统开发及其在病理生理学研究中的应用
  • 批准号:
    12670514
  • 财政年份:
    2000
  • 资助金额:
    $ 5.44万
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
PREPARATION OF NOVEL HEMOCOMPATIBLE HOLLOW FIBER MEMBRANE AND DEVICE FOR SAFETY BLOOD PURIFICATION HOME
新型血液相容性中空纤维膜及安全血液净化装置的制备
  • 批准号:
    10558131
  • 财政年份:
    1998
  • 资助金额:
    $ 5.44万
  • 项目类别:
    Grant-in-Aid for Scientific Research (B)
Mucus secretion studies using anti-gastric mucin monoclonal antibodies
使用抗胃粘蛋白单克隆抗体进行粘液分泌研究
  • 批准号:
    07670612
  • 财政年份:
    1995
  • 资助金额:
    $ 5.44万
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
Preparation of Novel Biocompatible polymeric Additives and Modification of Biomedical Materials Using the Additives
新型生物相容性高分子添加剂的制备及其对生物医用材料的改性
  • 批准号:
    07680934
  • 财政年份:
    1995
  • 资助金额:
    $ 5.44万
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)

相似海外基金

Artificial Organ and Complement----Basic Studies for Development of New Biomedical Polymer
人工器官及补体----新型生物医用高分子材料开发的基础研究
  • 批准号:
    62870104
  • 财政年份:
    1987
  • 资助金额:
    $ 5.44万
  • 项目类别:
    Grant-in-Aid for Developmental Scientific Research
U.S.-Japan Joint Seminar: Biomedical Polymer Science/ Kyoto, Japan/November, 1985
美日联合研讨会:生物医学高分子科学/日本京都/1985 年 11 月
  • 批准号:
    8414529
  • 财政年份:
    1985
  • 资助金额:
    $ 5.44万
  • 项目类别:
    Standard Grant
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