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PREPARATION OF NOVEL BIOMEDICAL POLYMERS HAUING BIOMEMBRANE-LIKE SURFACE AND RECOGNITION OF THEIR NON THROMBOGENIC

具有类生物膜表面的新型生物医用聚合物的制备及其非血栓形成的识别

基本信息

批准号：
09480250
负责人：
ISHIHARA Kazuhiko
金额：
$ 5.44万
依托单位：
THE UNIVERSITY OF TOKYO (1998-2000)Tokyo Medical and Dental University (1997)
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (B).
财政年份：
1997
资助国家：
日本
起止时间：
1997 至 2000
项目状态：
已结题

项目摘要

Novel polymer biomaterials, which can use in contact with blood, are prepared with strong inspiration from the surface structure of biomembrane. That is, the polymers with phospholipid polar group in the side chain, 2-methacrylooyloxyethyl phosphorylcholine (MPC) polymers were synthesized. The MPC polymers can inhibit surface-induced clot formation effectively, even when they contact with blood in the absence of anticoagulant. This phenomenon was due to reduction of plasma protein and suppression of denaturation of adsorbed proteins. That is, the MPC polymers interact with blood components very mildly.The amount of protein adsorbed on the polymer surface had a close relation to the free water fraction in the hydrated polymer. A comparison of the conformational change in proteins adsorbed on the MPC polymers and poly (HEMA) revealed that the effectiveness of the phosphorylcholine group in preventing the change, and the protein on the MPC polymer maintained its original state. Thus, it is concluded that the free water fraction is one of the most important factors in controlling the protein adsorption process.As the molecular structure of the MPC polymer was easily designed by changing monomer units and composition, it could apply to surface modification of artificial organs and biomedical devices for improving blood compatibility and tissue compatibility. Thus, the MPC polymers are useful polymer biomaterials for making high performance artificial organs and biomedical devices to provide safety medical treatments.

从生物膜的表面结构中获得强烈灵感，制备出可与血液接触的新型高分子生物材料。即合成了侧链上具有磷脂极性基团的聚合物- 2-甲基丙烯酰氧乙基磷酸胆碱（MPC）聚合物。即使在没有抗凝剂的情况下与血液接触，MPC聚合物也能有效地抑制表面诱导的血块形成。这种现象是由于血浆蛋白的减少和吸附蛋白变性的抑制。也就是说，MPC聚合物与血液成分的相互作用非常温和。蛋白质在聚合物表面的吸附量与水合聚合物中游离水的含量密切相关。比较了蛋白质吸附在MPC聚合物和聚HEMA上的构象变化，发现磷酸胆碱基团有效地阻止了这种变化，MPC聚合物上的蛋白质保持了原来的状态。由此可见，游离水分数是控制蛋白质吸附过程的重要因素之一。由于MPC聚合物的分子结构易于通过改变单体单元和组成进行设计，因此可以应用于人工器官和生物医学设备的表面修饰，以提高血液相容性和组织相容性。因此，MPC聚合物是一种有用的高分子生物材料，可用于制造高性能的人造器官和生物医学设备，以提供安全的医疗。