Preparation of biocompatible polymer nanoparticles as cell-function analysis biodevices

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Polymeric nanoparticles for new cell-function analytical biodevices were prepared. The polymeric nanoparticles covered with phospholipid polymer, which functioned as artificial cell membrane, and quantum dots were embedded in the polymer nanoparticles. Moreover, special functional biomolecules, oligopeptide, were introduced on the surface to understand their functions to the cell responses. Effects of phospholipid polymer were clearly demonstrated that the nanoparticles did not internalize to the cells without biomolecules on the surface. On the other hand, when the some specific oligopeptide were immobilized on the surface, the nanoparticles turned to cell-penetrative. That is, it could be concluded that the chemical structure, sequence, and density of the oligopeptide strongly influence cell internalization of the nanoparticle.