Structure Control and Functions of Biocompatible Polymer Alloy as Biomaterials

在本研究中，研究了由传统高分子材料，如聚氨酯和聚砜、聚烯烃和新设计的磷脂聚合物组成的聚合物合金。为了提高分段聚氨酯（SPU）的生物相容性，在SPU中掺入2-甲基丙烯酰氧乙基磷胆碱（MPC）共聚物，如Pellethane【R】和TM-3【〇！R】，用溶剂蒸发法从含有SPU和MPC共聚物的均相溶液中提取。x射线电子能谱（XPS）表明，当MPC共聚物与基体SPU的比例仅为7.5 w/w %时，MPC部分仍位于SPU膜的表面。通过拉伸应力-应变测量，SPU膜的力学性能在加入MPC共聚物后变化很小。通过血浆蛋白吸附和血细胞在膜表面的粘附，评价了MPC共聚物共混膜的生物相容性。MPC共聚物的加入显著降低了SPU膜上纤维蛋白原的吸附量。此外，在SPU膜中加入MPC共聚物抑制了血小板的粘附和活化。结果表明，在SPU膜中共混MPC共聚物是提高SPU膜生物相容性的有效方法。聚砜中空纤维膜是一种新型的由蛋白质吸附沉积而成的无污染聚砜中空纤维膜。为了提高PSf中空纤维在血液透析器中的亲水性、渗透性和无污染特性，我们合成了一种MPC聚合物，并将其与PSf共混制备聚合物合金（PSf/MPC聚合物）。混合在PSf中的MPC聚合物的组成在7.0 - 15 wt%之间。PSf/MPC聚合物溶液可以制备扁平膜和中空纤维。这些膜具有不对称结构，机械强度好。利用XPS对PSf/MPC聚合物中空纤维膜进行表面表征，发现MPC单元集中在表面。与PSf膜相比，PSf/MPC膜对溶质的渗透性更高，对蛋白质的吸附量更少。此外，PSf/MPC聚合物膜也能有效抑制血小板粘附

In this research, polymer alloys composed of conventional polymer materials, such as, polyurethane and polysulfone, polyolefine and newly designed phospholipid polymers were researched as follows :To improve the biocompatibility of a segmented polyurethane (SPU), 2-methacryloyloxyethyl phosphorylcholine (MPC) copolymer was blended in the SPUs, such as Pellethane【○!R】 and TM-3【○!R】, by a solvent evaporation method from a homogeneous solution containing both SPU and MPC copolymer. X-ray electron spectra(XPS) indicated that the MPC moieties were located at the surface of the SPU membrane blended with the MPC copolymer even when the composition of the MPC copolymer was only 7.5 w/w % against the matrix SPU. The mechanical property of the SPU membranes, as determined by tensile stress-strain measurements, changed very little by addition of the MPC copolymer. Biocompatibility of the MPC copolymer blended membrane was evaluated by plasma protein adsorption and blood cell adhesion on the surfa … More ce. The amount of fibrinogen adsorbed on the SPU membrane significantly decreased by addition of the MPC copolymers. Moreover, addition of MPC copolymer in the SPU membrane suppressed platelet adhesion and activation. It is concluded that the blending of the MPC copolymer in the SPU membrane is an effective method to improve biocompatibility of the SPU membrane.Nonfouling polysulfone hollow fiber membranes from protein adsorption and deposition were newly developed by addition of MPC polymer. To improve hydrophilicity, permeability, and nonfouling characteristics of the PSf hollow fiber in a hemodialyzer, we synthesized a MPC polymer, which can be blended with PSf for preparing the polymer alloy (PSf/MPC polymer). The composition of the MPC polymer blended in the PSf was in the range between 7.0 and 15-wt%. From the PSf/MPC polymer solution, flat membranes and hollow fiber could be prepared. These membranes took an asymmetric structure and its mechanical strength was good. The surface characterization of the PSf/MPC polymer hollow fiber membrane by XPS revealed that the MPC units were concentrated at the surface. The permeability for solutes through the PSf/MPC polymer membrane was higher and the amount of protein adsorbed on the PSf/MPC polymer membrane was lower than those of the PSf membrane. Moreover, platelet adhesion was also effectively inhibited on the PSf/MPC polymer membrane Less