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Structure Control and Functions of Biocompatible Polymer Alloy as Biomaterials

生物相容性聚合物合金作为生物材料的结构控制和功能

基本信息

批准号：
13480288
负责人：
ISHIHARA Kazuhiko
金额：
$ 9.41万
依托单位：
The University of Tokyo
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (B)
财政年份：
2001
资助国家：
日本
起止时间：
2001 至 2004
项目状态：
已结题

项目摘要

In this research, polymer alloys composed of conventional polymer materials, such as, polyurethane and polysulfone, polyolefine and newly designed phospholipid polymers were researched as follows :To improve the biocompatibility of a segmented polyurethane (SPU), 2-methacryloyloxyethyl phosphorylcholine (MPC) copolymer was blended in the SPUs, such as Pellethane【○!R】 and TM-3【○!R】, by a solvent evaporation method from a homogeneous solution containing both SPU and MPC copolymer. X-ray electron spectra(XPS) indicated that the MPC moieties were located at the surface of the SPU membrane blended with the MPC copolymer even when the composition of the MPC copolymer was only 7.5 w/w % against the matrix SPU. The mechanical property of the SPU membranes, as determined by tensile stress-strain measurements, changed very little by addition of the MPC copolymer. Biocompatibility of the MPC copolymer blended membrane was evaluated by plasma protein adsorption and blood cell adhesion on the surfa … More ce. The amount of fibrinogen adsorbed on the SPU membrane significantly decreased by addition of the MPC copolymers. Moreover, addition of MPC copolymer in the SPU membrane suppressed platelet adhesion and activation. It is concluded that the blending of the MPC copolymer in the SPU membrane is an effective method to improve biocompatibility of the SPU membrane.Nonfouling polysulfone hollow fiber membranes from protein adsorption and deposition were newly developed by addition of MPC polymer. To improve hydrophilicity, permeability, and nonfouling characteristics of the PSf hollow fiber in a hemodialyzer, we synthesized a MPC polymer, which can be blended with PSf for preparing the polymer alloy (PSf/MPC polymer). The composition of the MPC polymer blended in the PSf was in the range between 7.0 and 15-wt%. From the PSf/MPC polymer solution, flat membranes and hollow fiber could be prepared. These membranes took an asymmetric structure and its mechanical strength was good. The surface characterization of the PSf/MPC polymer hollow fiber membrane by XPS revealed that the MPC units were concentrated at the surface. The permeability for solutes through the PSf/MPC polymer membrane was higher and the amount of protein adsorbed on the PSf/MPC polymer membrane was lower than those of the PSf membrane. Moreover, platelet adhesion was also effectively inhibited on the PSf/MPC polymer membrane Less

本研究以传统的高分子材料如聚氨酯、聚砜、聚烯烃和新型的磷脂聚合物为原料，制备了高分子合金。为了改善嵌段聚氨酯（SPU）的生物相容性，将2-甲基丙烯酰氧乙基磷酰胆碱（MPC）共聚物与聚氨酯（Pellethane[○！R]和TM-3[○！R]，通过溶剂蒸发法从含有SPU和MPC共聚物的均相溶液中制备。X-射线电子能谱（XPS）表明，MPC部分位于与MPC共聚物共混的SPU膜的表面，即使当MPC共聚物的组成仅为相对于基质SPU的7.5w/w %时。SPU膜的机械性能，通过拉伸应力-应变测量确定，通过添加MPC共聚物改变非常小。以血浆蛋白吸附和血细胞粘附为指标评价MPC共聚物共混膜的生物相容性。 ...更多信息 ce.通过添加MPC共聚物，SPU膜上吸附的纤维蛋白原的量显著降低。此外，在SPU膜中添加MPC共聚物可抑制血小板粘附和活化。结果表明，MPC共聚物与SPU膜的共混是改善SPU膜生物相容性的有效方法，通过MPC共聚物的加入，可制备出不污染蛋白质吸附和沉积的聚砜中空纤维膜。为了改善PSf中空纤维在血液透析器中的亲水性、渗透性和不污染特性，我们合成了MPC聚合物，其可与PSf共混以制备聚合物合金（PSf/MPC聚合物）。在PSf中共混的MPC聚合物的组成在7.0和15重量%之间的范围内。由PSf/MPC聚合物溶液，可以制备平板膜和中空纤维。这些膜具有不对称结构，并且其机械强度良好。通过XPS对PSf/MPC聚合物中空纤维膜的表面表征表明，MPC单元集中在表面。溶质通过PSf/MPC聚合物膜的渗透性更高，吸附在PSf/MPC聚合物膜上的蛋白质的量低于PSf膜。此外，血小板粘附在PSf/MPC聚合物膜上也被有效地抑制。