Preparation of Novel Biocompatible polymeric Additives and Modification of Biomedical Materials Using the Additives
新型生物相容性高分子添加剂的制备及其对生物医用材料的改性
基本信息
- 批准号:07680934
- 负责人:
- 金额:$ 1.41万
- 依托单位:
- 依托单位国家:日本
- 项目类别:Grant-in-Aid for Scientific Research (C)
- 财政年份:1995
- 资助国家:日本
- 起止时间:1995 至 1996
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
To improve the blood compatibility of a segmented polyurethane (SPU), 2-methacryloyloxyethyl phosphorylcholine (MPC) polymer was blended in the SPU.The blended membranes composed of SPU and MPC polymers were prepared by a solvent evaporation method. Surface analysis of the SPU membrane blended with the MPC polymer (SPU/MPC polymer) revealed that the MPC polymer was concentrated at the surface of the SPU membrane which contacted the substrate compared with that which contacted air during the membrane formation period. The size of the domains of the MPC polymer became smaller but the number of the domains increased. The amount of the MPC polymer mexed with SPU affected the dispersion state. The mechanical properties of the SPU membrane, as determined by tensile stress-strain measurements, changed very little even after addition of the MPC polymers. Plasma proteins adsorbed on the SPU/MPC polymer membrane surface after contact with human plasma were detected by gold-colloid labeled immunoassay. Both albumin and fibrinogen were observed on the SPU membrane ; however, the amount of these proteins was reduced on the SPU/MPC polymer membrane. It was concluded that the blood compatibility of the SPU was effectively improved by the blending of the MPC polymer. The addition of MPC polymer in the SPU membrane dramatically reduced cell adhesion. It is concluded that the blending of the MPC polymer in the SPU membrane is an effective method to impart nonthrombogenicity. By using of this SPU/MPC polymer blend, small-diameter vascular prosthesis was prepared. The prosthesis indicated excellent performance compared with normal or original prosthesis, that is, during more than 8 months the SPU/MPC polymer blend prosthesis did not osculate even when the prosthesis was implanted into rabbit vain.
为了提高分段聚氨酯(SPU)的血液相容性,在SPU中掺入了2-甲基丙烯酰氧乙基磷酸胆碱(MPC)聚合物。采用溶剂蒸发法制备了SPU和MPC共混膜。对SPU/MPC聚合物共混膜(SPU/MPC聚合物)的表面分析表明,在膜形成过程中,MPC聚合物集中在SPU膜与基质接触的表面,而不是与空气接触的表面。MPC聚合物的结构域变小了,但结构域的数量增加了。MPC聚合物与SPU的掺量对分散状态有影响。通过拉伸应力应变测量,SPU膜的力学性能即使在加入MPC聚合物后也几乎没有变化。用金胶体标记免疫法检测SPU/MPC聚合物膜与人血浆接触后吸附在其表面的血浆蛋白。SPU膜上可见白蛋白和纤维蛋白原;然而,这些蛋白质的数量在SPU/MPC聚合物膜上减少。结果表明,MPC聚合物的掺入有效地改善了SPU的血液相容性。在SPU膜中加入MPC聚合物可显著降低细胞粘附。结果表明,在SPU膜中共混MPC聚合物是一种具有非血栓形成性的有效方法。利用SPU/MPC聚合物共混物制备了小直径血管假体。与正常假体或原假体相比,SPU/MPC聚合物混合假体在8个月以上的时间内即使植入兔体内也没有发生接触。
项目成果
期刊论文数量(13)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
石原一彦: "血液適合性セグメント化ポリウレタン/リン脂質ポリマーブレンドの合成と評価" 東医歯大 医器材研報. 30. 18-30 (1996)
Kazuhiko Ishihara:“血液相容性链段聚氨酯/磷脂聚合物共混物的合成和评价”东京医科齿科大学医疗设备研究报告。 30. 18-30 (1996)。
- DOI:
- 发表时间:
- 期刊:
- 影响因子:0
- 作者:
- 通讯作者:
K.Ishihara: "Improved blood compatibility of segmented polyurethanes by polymeric additires having phogphelipid poiar groups.I." J.Biomed.Mater.Res.32. 391-399 (1996)
K.Ishihara:“通过具有磷脂极性基团的聚合物添加剂改善了嵌段聚氨酯的血液相容性。I。”
- DOI:
- 发表时间:
- 期刊:
- 影响因子:0
- 作者:
- 通讯作者:
K.Ishihara.: "Improved blood compatibility of segmented polyurethane by polymeric additives having phosphdipid polar group II." J. Biomed. Mater. Res.32. 401-408 (1996)
K.Ishihara.:“通过具有磷脂极性基团 II 的聚合物添加剂改善了嵌段聚氨酯的血液相容性。”
- DOI:
- 发表时间:
- 期刊:
- 影响因子:0
- 作者:
- 通讯作者:
Kazuhiko Ishihara: "Improved Blood Compatibility of Segmented Polyurehtanes by Polymeric Addithves Having Phospholipid Polar Groups.I." J.Biomed.Mater.Res.32 (4). 391-399 (1996)
Kazuhiko Ishihara:“通过具有磷脂极性基团的聚合物添加剂改善分段聚氨酯的血液相容性。I”
- DOI:
- 发表时间:
- 期刊:
- 影响因子:0
- 作者:
- 通讯作者:
K.Ishihara: "Improved blood compatibility of segmented polyurethanes by polymeric additives having phospholipid Poiar groaps. I." J. Biomed. Mater. Res.32. 391-399 (1996)
K.Ishihara:“通过含有磷脂 Poiar 基团的聚合物添加剂改善了分段聚氨酯的血液相容性。I.”
- DOI:
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- 影响因子:0
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ISHIHARA Kazuhiko其他文献
Synthesis of Thereto-Responsive Hydrogel Cross-Linked by Gold Nano Collaid
金纳米胶交联响应性水凝胶的合成
- DOI:
- 发表时间:
2010 - 期刊:
- 影响因子:0
- 作者:
GOTO Fumi;YUSA Shin-ichi;MORISHIMA Yotaro;ISHIHARA Kazuhiko - 通讯作者:
ISHIHARA Kazuhiko
ISHIHARA Kazuhiko的其他文献
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{{ truncateString('ISHIHARA Kazuhiko', 18)}}的其他基金
Preparation of cell-based electron-generator
细胞电子发生器的制备
- 批准号:
22650107 - 财政年份:2010
- 资助金额:
$ 1.41万 - 项目类别:
Grant-in-Aid for Challenging Exploratory Research
Preparation of biocompatible polymer nanoparticles as cell-function analysis biodevices
作为细胞功能分析生物器件的生物相容性聚合物纳米颗粒的制备
- 批准号:
21300176 - 财政年份:2009
- 资助金额:
$ 1.41万 - 项目类别:
Grant-in-Aid for Scientific Research (B)
Study on a formulation of housing policy vision by character of area and renewal policy in suburb from view point of shrinking city
收缩城市视角下分区特征住房政策愿景制定及郊区更新政策研究
- 批准号:
18600009 - 财政年份:2006
- 资助金额:
$ 1.41万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
DETERMINATION OF MECHANISM FOR MOLECULAR ADHESION TO SOFT TISSUES AND MATERALS PREPARATION
软组织分子粘附机制的测定及材料制备
- 批准号:
17300144 - 财政年份:2005
- 资助金额:
$ 1.41万 - 项目类别:
Grant-in-Aid for Scientific Research (B)
Function of gastro-intestinal mucin-derived acidic oligosaccharaides recognized by anti-mucin monoclonal antibodies
抗粘蛋白单克隆抗体识别的胃肠粘蛋白衍生酸性寡糖的功能
- 批准号:
16590629 - 财政年份:2004
- 资助金额:
$ 1.41万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
Structure Control and Functions of Biocompatible Polymer Alloy as Biomaterials
生物相容性聚合物合金作为生物材料的结构控制和功能
- 批准号:
13480288 - 财政年份:2001
- 资助金额:
$ 1.41万 - 项目类别:
Grant-in-Aid for Scientific Research (B)
A systematic development of monoclonal antibodies against mucins of digestive tract and their application to pathophysiological studies
抗消化道粘蛋白单克隆抗体的系统开发及其在病理生理学研究中的应用
- 批准号:
12670514 - 财政年份:2000
- 资助金额:
$ 1.41万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
PREPARATION OF NOVEL HEMOCOMPATIBLE HOLLOW FIBER MEMBRANE AND DEVICE FOR SAFETY BLOOD PURIFICATION HOME
新型血液相容性中空纤维膜及安全血液净化装置的制备
- 批准号:
10558131 - 财政年份:1998
- 资助金额:
$ 1.41万 - 项目类别:
Grant-in-Aid for Scientific Research (B)
PREPARATION OF NOVEL BIOMEDICAL POLYMERS HAUING BIOMEMBRANE-LIKE SURFACE AND RECOGNITION OF THEIR NON THROMBOGENIC
具有类生物膜表面的新型生物医用聚合物的制备及其非血栓形成的识别
- 批准号:
09480250 - 财政年份:1997
- 资助金额:
$ 1.41万 - 项目类别:
Grant-in-Aid for Scientific Research (B).
Mucus secretion studies using anti-gastric mucin monoclonal antibodies
使用抗胃粘蛋白单克隆抗体进行粘液分泌研究
- 批准号:
07670612 - 财政年份:1995
- 资助金额:
$ 1.41万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
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