Antihypertensive peptides without no side effect such as dry vomiting from milk proteins and their application
Antihypertensive peptides without no side effect such as dry vomiting from milk proteins and their application
批准号:
14360158
负责人:
SAITO Tadao
金额:
$8.0万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (B)
财政年份:
2002
资助国家:
日本
项目状态:
已结题
起止时间:
2002 至 2003
中文摘要
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英文摘要
The main purpose of this research is preparation of antihypertensive peptides without any side effects such as dry vomiting from milk proteins and their application for new functional foods and medicine.We constructed a new peptide library form commercial peptide products from DMV Company (Holland) which is very famous international company producing peptide of food additive grade. We isolated a tetra peptide : ALPM after hydrophobic-, ion-exchange chromatography and HPLC analysis. The peptide showed strong antihypertesivity by SHR (spontaneously hypertensive rats) and ACE inhibitory activities. The membrane expressing AT1 receptors were isolated from rat lungs. We tested the competitive inhibitory analysis with ALPM and I125labeled-angiotesin peptide II for the binding to AT1 receptor of the membrane. We first confirmed the inhibitory activity in ALPM and proposed the future application for the food or medicine.
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Tadao Saito: "Selection of useful probiotic lactic acid bacteria from the Lactobacillus acidophilus group and their applications to functional foods."Animal Science Journal. 75. 1-13 (2004)
Tadao Saito:“从嗜酸乳杆菌群中选择有用的益生菌乳酸菌及其在功能性食品中的应用。”《动物科学杂志》。
DOI:
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作者:
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通讯作者:
齋藤忠夫, 村上まり子, 殿内秀和: "ミルク・ヨーグルト・チーズで血圧を下げる!"畜産の研究. 57(5). 573-579 (2003)
Tadao Saito、Mariko Murakami、Hidekazu Tonouchi:“用牛奶、酸奶和奶酪降低血压!” 57(5) (2003)。
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作者:
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通讯作者:
Tadao SAITO: "Selection of useful probiotic lactic acid bacteria from the L.acidophilus group and their applications to functional foods."Animal Science Journal. 75. 1-13 (2004)
Tadao SAITO:“从嗜酸乳杆菌群中选择有用的益生菌乳酸菌及其在功能性食品中的应用。”《动物科学杂志》。
DOI:
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发表时间:
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影响因子:
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作者:
[]
通讯作者:
齋藤忠夫: "一貫して「ミルク科学」の研究を中心に"牛乳生活情報. 31. 27-28 (2004)
Tadao Saito:“始终专注于‘牛奶科学’的研究”《牛奶生活方式信息》,31. 27-28 (2004)。
DOI:
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发表时间:
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影响因子:
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作者:
[]
通讯作者:
齋藤忠夫, 村上まり子, 殿内秀和: "ミルク・ヨーグルト・チーズで血圧を下げる!"畜産の研究. 57. 573-579 (2003)
Tadao Saito、Mariko Murakami、Hidekazu Tonouchi:“用牛奶、酸奶和奶酪降低血压!” 57. 573-579 (2003)。
DOI:
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发表时间:
期刊:
影响因子:
--
作者:
[]
通讯作者:
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