Development of New Catalytic Reactions Directed to Straightforward Synthesis of Unused Carbon Sources

开发直接合成未使用碳源的新催化反应

• 批准号: 22245016
• 负责人: CHATANI Naoto
• 金额: $ 30.95万
• 依托单位: Osaka University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (A)
• 财政年份: 2010
• 资助国家: 日本
• 起止时间: 2010-04-01 至 2013-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-22245016/
• 关键词: 炭素資源; 炭素－水素結合活性化; 炭素－炭素結合活性化; 炭素－酸素結合活性化; 炭素－ケイ素結合活性化; 炭素－フッ素結合活性化; 直截的物質変換; ベンゾシロール; 炭素-水素結合活性化; 炭素-酸素結合活性化; 炭素-ケイ素結合活性化; 炭素-フッ素結合活性化; 炭素-シアノ結合活性化

It was found that nickel complexes show high catalytic activity in Suzuki coupling, amination and reduction of anisole derivatives, which involve the activation of carbon-methoxy bonds. Silyl-rhodium species were found to be a superior catalytic active species for the activation of C-CN bonds. We found silylation, borylation, and phenylation reactions involving the cleavage of C-CN bonds. Based on these results, we successfully discovered a new synthesis of benzosiloles, which have interesting electronic properties. We found the Ru-catalyzed carbonylation of C(sp3)-H bonds in aliphatic amides that contain an 8-aminoquinoline directing group.

结果表明，镍配合物在苯甲醚衍生物的Suzuki偶联、胺化和还原反应中表现出较高的催化活性，这些反应涉及到碳-甲氧基键的活化。硅铑物种被发现是一个上级催化活性物种的C-CN键的活化。我们发现，硅烷化，硼化和苯基化反应涉及C-CN键的裂解。基于这些结果，我们成功地发现了一种新的合成苯并硅杂环戊烯，具有有趣的电子性质。我们发现钌催化的羰基化的C（sp3）-H键的脂肪酰胺，含有8-氨基喹啉导向基团。

项目成果

Chelation-Assisted Transformations Involving C-H Bond Activation

涉及 C-H 键激活的螯合辅助转化

• 发表时间: 2012
• 作者: Chatani;N
• 通讯作者: N

Nickel-Catalyzed Cyclization of Difluoro-Substituted 1,6-Enynes with Organozinc Reagents

有机锌试剂镍催化二氟取代 1,6-烯炔的环化

• 发表时间: 2010
• 期刊: Angewandte Chemie International Edition
• 作者: Naoto Chatani;et al
• 通讯作者: et al

Regioselective Carbonylation of Unactivated C(sp^3)-H Bonds Catalyzed by Ru^3(CO)^<12>

Ru^3(CO)^<12> 催化未活化 C(sp^3)-H 键的区域选择性羰基化

• 发表时间: 2011
• 作者: Chatani;N
• 通讯作者: N

Transformations Involving C-H Bond Activation Utilizing a Bidentate Directing System

涉及利用双齿定向系统激活 C-H 键的转化

• 发表时间: 2012
• 作者: Chatani;N
• 通讯作者: N

Regioselective Carbonylation of Unactivated C(sp3)-H Bonds in Aliphatic

脂肪族中未活化的 C(sp3)-H 键的区域选择性羰基化

• 发表时间: 2011
• 作者: H. Wang;S. Hamanaka;Y. Nishimoto;S. Irle;T. Yokoyama;H. Yoshikawa and K. Awaga;畠山力三;Naoto Chatani
• 通讯作者: Naoto Chatani