Development of monitoring system for effects of ultra low level microwave with changing

超低强度微波效应变化监测系统研制

• 批准号: 12557035
• 负责人: NAKAMURA Hiroyuki
• 金额: $ 8.13万
• 依托单位: Kanazawa University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2000
• 资助国家: 日本
• 起止时间: 2000 至 2001
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-12557035/
• 关键词: microwaves; prostagiandin; uteroplacental blood flow; pregnancy; progesterone; heat; SAR; immunity; 物理的環境刺激; 電界; 磁界

We developed microwave device simulating actual environmental exposure of very low level with changing frequencies produced by recent communicating instruments. The field was generated by signal simulation of the Global System for Mobile communications (GSM) of 960 MHz. Subjects were exposed in a specially constructed chamber, a Transverse Electromagnetic (TEM) cell. The Specific Absorption Rate (SAR) value for each cell well was calculated for this exposure system. Microwaves of 2 and 10 mW/cm^2 elevated 0.98±0.12, 3.70±0.15℃ (Mean±SE) , respectively, of rectal temperature hi rats after continuous exposure of 90 min, and 0.22±0.19, 1.69±0.20℃, respectively after 180 min. Heat during microwaves produce uteroplacental circulatory disturbances, "subsequently causing abortion. The decreases in uteroplacental blood flow accompanying microwaves of 2 and 10 mW/cm^2 were reversible and irreversible changes, respectively. Pretreatment with progesterone receptor antagonist mifepristone produced irreversible change during microwaves of 2 mW/cm^2 with a simultaneous decrease in Prostaglandin (PG)E_2, but not changed NK cell activity. Therefore, the irreversible decrease in uteroplacental blood flow seems to be due to the actions of progesterone and PGE_2.in cooperation with cellular immune function. The homeostasis of endocrine-immune system is important to prevent pregnancy from effects of ultra low level microwaves with changing frequencies.

我们研制了一种微波装置，利用现代通信仪器产生的变化频率，模拟极低水平的实际环境暴露。该场是由960 MHz的全球移动的通信系统（GSM）的信号模拟产生的。受试者被暴露在一个特殊构造的室，一个横向电磁（TEM）细胞。计算该暴露系统每个细胞孔的比吸收率（SAR）值。2和10 mW/cm ^2的微波连续照射90 min后，大鼠直肠温度分别升高0.98±0.12和3.70±0.15℃（平均值±标准误），180 min后分别升高0.22±0.19和1.69±0.20℃。微波加热引起子宫胎盘循环障碍，随后导致流产。2和10 mW/cm ^2微波引起的子宫胎盘血流减少分别为可逆和不可逆变化。孕激素受体拮抗剂米非司酮预处理后，在2 mW/cm^2微波辐射下，NK细胞活性无明显改变，但前列腺素E2（PG E2）水平明显降低。因此，子宫胎盘血流量的不可逆性下降可能是由于孕酮和PGE_2与细胞免疫功能的协同作用。内分泌-免疫系统的稳态对于预防频率变化的超低强度微波对妊娠的影响是重要的。

项目成果

Nakamura H,Nagase H,Ogino K,Hatta K and Matuzaki I: "Uteroplacental circulatory disturbance in pregnant rats exposed to microwaves through actions of prostaglandin F2α"Reprod Toxicol. 14. 235-240 (2000)

Nakamura H、Nagase H、Ogino K、Hatta K 和 Matuzaki I：“通过前列腺素 F2α 的作用，暴露于微波的怀孕大鼠的子宫胎盘循环障碍”Reprod Toxicol. 14. 235-240 (2000)

Nakamura H, Ogawa Y, Nagase H, Nakajima M, Kodama N, Ogino K, Ooshita Y: "Natural killer cell activity and its related psychological factor, sense of coherence in male smokers"J Occup Health. 43. 191-8 (2001)

Nakamura H、Okawa Y、Nagase H、Nakajima M、Kodama N、Ogino K、Ooshita Y：“男性吸烟者的自然杀伤细胞活性及其相关心理因素、连贯感”J Occup Health。

Nakamura H,Nagase H,Ogino K,Hatta K and Matuzaki I: "Heat produces uteroplacental circulatory disturbance in pregnant rats through action of corticotropin releasing hormone (CRH)"Placenta. 21. 510-515 (2000)

Nakamura H、Nagase H、Ogino K、Hatta K 和 Matuzaki I：“热量通过促肾上腺皮质激素释放激素 (CRH) 的作用在怀孕大鼠中产生子宫胎盘循环障碍”胎盘。

Nakamura H, Nagase H, Ogino K, Hatta K, Matsuzaki I: "Heat produces uteroplacental circulatory disturbance in pregnant rats through action of corticotropin releasing hormone (CRH)"Placenta. 21. 510-5 (2000)

Nakamura H、Nagase H、Ogino K、Hatta K、Matsuzaki I：“热量通过促肾上腺皮质激素释放激素 (CRH) 的作用在怀孕大鼠中产生子宫胎盘循环障碍”胎盘。

Nakamura H, Nagase H, Ogino K, Hatta K, Matsuzaki I: "Involvement of central, but not placental corticotropin releasing hormone(CRH) in heat stress-induced immunosuooression during pregnancy"Brain Behav Immun. 15. 43-53 (2001)

Nakamura H、Nagase H、Ogino K、Hatta K、Matsuzaki I：“中枢但不是胎盘促肾上腺皮质激素释放激素 (CRH) 参与妊娠期间热应激诱导的免疫抑制”脑行为免疫。