The role of extracellular matrix degradation enzymes, MMP and ADAM in tumor micro environment (stem cell niche)
The role of extracellular matrix degradation enzymes, MMP and ADAM in tumor micro environment (stem cell niche)
批准号:
22592030
负责人:
NAKAMURA Hiroyuki
金额:
$2.91万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2010
资助国家:
日本
项目状态:
已结题
起止时间:
2010 至 2012
中文摘要
在口腔肿瘤微环境(干细胞生态位)中,细胞外基质降解酶、MMP和ADAM在肿瘤侵袭转移过程中的作用尚不清楚。为了解决这一问题,我们建立了在小生境细胞中特异性表达MMP或ADAM特异性抑制剂的转基因小鼠,并试图确定哪些蛋白酶参与了口腔肿瘤微环境的调节
英文摘要
In oral tumor micro environment (stem cell niche), the role of extracellular matrix degradation enzymes, MMP and ADAM which is critical for tumor invasion and metastasis, is not clear. To address this question, we establish transgenic mice which overexpress MMP or ADAM specific inhibitor in niche cells specifically, and try to identify which protease is involved in regulation of oral tumor micro environment
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
登录
查看更多内容
MMP-3 の歯髄炎での抗炎症, 組織再生作用の検討
MMP-3对牙髓炎的抗炎和组织再生作用的检测
DOI:
--
发表时间:
2012
期刊:
影响因子:
--
作者:
[Sonnylal, S., Shi-Wen, X., Leoni, P., Naff, K., Van Pelt, CS., Nakamura, H., Leask, A., Abraham, D., Bou-Gharios, G., and de Crombrugghe, B., 中村博幸, 中村博幸, 中村博幸, 中村博幸, 中村博幸]
通讯作者:
中村博幸
細胞外マトリックス分解最近の知見
细胞外基质降解的最新发现
DOI:
--
发表时间:
2011
期刊:
影响因子:
--
作者:
[Sonnylal, S., Shi-Wen, X., Leoni, P., Naff, K., Van Pelt, CS., Nakamura, H., Leask, A., Abraham, D., Bou-Gharios, G., and de Crombrugghe, B., 中村博幸, 中村博幸, 中村博幸, 中村博幸, 中村博幸, 中村博幸]
通讯作者:
中村博幸
炎症メディエーターメタロプロテアーゼ
炎症介质金属蛋白酶
DOI:
--
发表时间:
2010
期刊:
影响因子:
--
作者:
[中村博幸, 岡田保典]
通讯作者:
岡田保典
DOI:
10.1371/journal.pone.0052523
发表时间:
2012
期刊:
PloS one
影响因子:
3.7
作者:
[Eba H, Murasawa Y, Iohara K, Isogai Z, Nakamura H, Nakamura H, Nakashima M]
通讯作者:
Nakashima M
歯科再生医療の背景と最先端事情
牙科再生医学的背景和前沿情况
DOI:
--
发表时间:
2012
期刊:
影响因子:
--
作者:
[Sonnylal, S., Shi-Wen, X., Leoni, P., Naff, K., Van Pelt, CS., Nakamura, H., Leask, A., Abraham, D., Bou-Gharios, G., and de Crombrugghe, B., 中村博幸, 中村博幸, 中村博幸, 中村博幸]
通讯作者:
中村博幸
共 11 条
Epidemiological studies on environmental chemicals as risk factors for chronic sinusitis, including nasal polyps
-
批准号:19K22751
-
项目类别:Grant-in-Aid for Challenging Research (Exploratory)
-
资助金额:$3.99万
-
财政年份:2019
-
负责人:NAKAMURA Hiroyuki
-
依托单位:
A Study on Strategic Decision Accounting System for Global Business Investment
-
批准号:16K03981
-
项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$2.66万
-
财政年份:2016
-
负责人:NAKAMURA Hiroyuki
-
依托单位:
Development of new preventive methods for food allergy using of the analysis on epigenetics on lymphocytes and intestinal flora microbiome
-
批准号:15H04783
-
项目类别:Grant-in-Aid for Scientific Research (B)
-
资助金额:$10.48万
-
财政年份:2015
-
负责人:NAKAMURA Hiroyuki
-
依托单位:
Establishment of experimental models for the study of congenital cytomegalovirus infection
-
批准号:24591616
-
项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$3.41万
-
财政年份:2012
-
负责人:NAKAMURA Hiroyuki
-
依托单位:
Study on a regulation system of intracellular cholesterol transport by ceramide kinase
-
批准号:24790066
-
项目类别:Grant-in-Aid for Young Scientists (B)
-
资助金额:$2.91万
-
财政年份:2012
-
负责人:NAKAMURA Hiroyuki
-
依托单位:
Development of Boron Delivery System for Neutron Capture Therapy as a Minimally Invasive Cancer Therapy
-
批准号:23390013
-
项目类别:Grant-in-Aid for Scientific Research (B)
-
资助金额:$11.9万
-
财政年份:2011
-
负责人:NAKAMURA Hiroyuki
-
依托单位:
A functional MRI study on the regulation of stress mediated brain activity by biting.
-
批准号:22592063
-
项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$2.83万
-
财政年份:2010
-
负责人:NAKAMURA Hiroyuki
-
依托单位:
Newly development of liposomes vaccines using influenza virus andT cell epitope peptide derived from Japanese cedar pollen
-
批准号:22659121
-
项目类别:Grant-in-Aid for Challenging Exploratory Research
-
资助金额:$2.08万
-
财政年份:2010
-
负责人:NAKAMURA Hiroyuki
-
依托单位:
Electric field induced metallic state in oxide channel field-effect transistors
-
批准号:20840029
-
项目类别:Grant-in-Aid for Young Scientists (Start-up)
-
资助金额:$2.1万
-
财政年份:2008
-
负责人:NAKAMURA Hiroyuki
-
依托单位:
Determination and molecular and genetic marker in the allergy produced by RS virus infection and its prevention
-
批准号:20390170
-
项目类别:Grant-in-Aid for Scientific Research (B)
-
资助金额:$11.65万
-
财政年份:2008
-
负责人:NAKAMURA Hiroyuki
-
依托单位:
DEVELOPING THE MANAGEMENT ACCOUNTING SYSTEM OF JAPANESE SUBSIDIARIES IN CHINA
-
批准号:19530402
-
项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$1.91万
-
财政年份:2007
-
负责人:NAKAMURA Hiroyuki
-
依托单位:
Retinotopy and areal organization of the third tier visual cortex
-
批准号:18591912
-
项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$2.56万
-
财政年份:2006
-
负责人:NAKAMURA Hiroyuki
-
依托单位:
Development of Tyrosine Kinase Inhibitors Based on the Structures of Target Protein
-
批准号:18350090
-
项目类别:Grant-in-Aid for Scientific Research (B)
-
资助金额:$9.27万
-
财政年份:2006
-
负责人:NAKAMURA Hiroyuki
-
依托单位:
Prevention for allergic diseases by clarification of interaction between environmental chemicals and genes of eosinophil-related protein
-
批准号:17390174
-
项目类别:Grant-in-Aid for Scientific Research (B)
-
资助金额:$9.14万
-
财政年份:2005
-
负责人:NAKAMURA Hiroyuki
-
依托单位:
Search of tow-dimensional metallic state in a transition metal sulfide BaVS3 showing a metal-insulator transition
-
批准号:16540326
-
项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$2.56万
-
财政年份:2004
-
负责人:NAKAMURA Hiroyuki
-
依托单位:
Cash Flow Estimation for Environmental Capital Investment
-
批准号:16530290
-
项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$1.47万
-
财政年份:2004
-
负责人:NAKAMURA Hiroyuki
-
依托单位:
Research on the Evaluation of Color Space and Developing Three Dimensional Color Simulator.
-
批准号:16091215
-
项目类别:Grant-in-Aid for Scientific Research on Priority Areas
-
资助金额:$7.68万
-
财政年份:2004
-
负责人:NAKAMURA Hiroyuki
-
依托单位:
Objective evaluation of design for an OS screen using eye movement
-
批准号:13670345
-
项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$0.26万
-
财政年份:2001
-
负责人:NAKAMURA Hiroyuki
-
依托单位:
Study on preventing systems of fetus for uteroplacental circulatory disturbances and uteroplacental dysfunctions produced by microwaves
-
批准号:13470079
-
项目类别:Grant-in-Aid for Scientific Research (B)
-
资助金额:$9.28万
-
财政年份:2001
-
负责人:NAKAMURA Hiroyuki
-
依托单位:
Development of monitoring system for effects of ultra low level microwave with changing
-
批准号:12557035
-
项目类别:Grant-in-Aid for Scientific Research (B)
-
资助金额:$8.13万
-
财政年份:2000
-
负责人:NAKAMURA Hiroyuki
-
依托单位:
国内基金
海外基金
登录
查看更多内容
CMA/溶酶体轴失衡驱动的MMP13核转位及转录调控在骨关节炎中的作用机制研究
-
批准号:
-
项目类别:省市级项目
-
资助金额:--
-
批准年份:2026
-
负责人:徐瑞菱
-
依托单位:
基于“大气下陷”理论探讨升陷汤调控IL-17A/IL-17RA信号轴抑制MMP-2/MMP-9表达抗心衰大鼠心肌纤维化的作用机制
-
批准号:2026JJ80502
-
项目类别:省市级项目
-
资助金额:--
-
批准年份:2026
-
负责人:王雪
-
依托单位:
生殖支原体感染以MMP28为枢纽介导细胞外基质重塑及组织损伤的机制研究
-
批准号:2026JJ80225
-
项目类别:省市级项目
-
资助金额:--
-
批准年份:2026
-
负责人:谭湘芳
-
依托单位:
SDC1通过MMP11+CAF的细胞外基质重塑促进子宫颈癌化学免疫联合治疗耐药的机制研究
-
批准号:JCZRQNB202600504
-
项目类别:省市级项目
-
资助金额:--
-
批准年份:2026
-
负责人:
-
依托单位:
脾脏巨噬细胞糖酵解重编程促进细胞活化及MMP9表达介导川崎病炎症反应和冠状动脉病变的机制研究
-
批准号:JCZRLH202601362
-
项目类别:省市级项目
-
资助金额:--
-
批准年份:2026
-
负责人:
-
依托单位:
Er - Nd:YAG双激光联合治疗种植体周围炎前后龈沟液MMP-8、IL-Iβ细胞因子变化与临床疗效关系研究
-
批准号:2026JJ82235
-
项目类别:省市级项目
-
资助金额:--
-
批准年份:2026
-
负责人:曾婷雯
-
依托单位:
ADAM17通过调控MMP21促进肝细胞癌进展和M2型巨噬细胞极化
-
批准号:2026JJ82501
-
项目类别:省市级项目
-
资助金额:--
-
批准年份:2026
-
负责人:向宇琦
-
依托单位:
RSV非结构蛋白“劫持“宿主表观调控酶激活MMP-9转录致血脑屏障损伤及丙戊酸靶向干预研究
-
批准号:2026JJ50575
-
项目类别:省市级项目
-
资助金额:--
-
批准年份:2026
-
负责人:谭宇蓉
-
依托单位:
细菌纤维素复合敷料的电响应设计及其调控创面MMP-9/TIMP-1 通路促烧伤创面愈合机制研究
-
批准号:2026JJ82603
-
项目类别:省市级项目
-
资助金额:--
-
批准年份:2026
-
负责人:吴迎
-
依托单位:
溴莫尼定通过cAMP/PKA/CREB轴调控MMP-2表达延缓近视眼轴增长的机制研究
-
批准号:2026JJ70126
-
项目类别:省市级项目
-
资助金额:--
-
批准年份:2026
-
负责人:向爱群
-
依托单位: