Newly development of liposomes vaccines using influenza virus andT cell epitope peptide derived from Japanese cedar pollen
Newly development of liposomes vaccines using influenza virus andT cell epitope peptide derived from Japanese cedar pollen
批准号:
22659121
负责人:
NAKAMURA Hiroyuki
金额:
$2.08万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Challenging Exploratory Research
财政年份:
2010
资助国家:
日本
项目状态:
已结题
起止时间:
2010 至 2012
中文摘要
我们构建了脂质体疫苗,在α-GalCe中,将NKT细胞中的活性物质插入磷脂脂质体胶囊的双层中,并将杉木花粉衍生的T细胞表位包含并附着在CTL表位表面。我们检测了流感病毒感染和杉木花粉致敏的模型小鼠的IFV滴度。结果表明,在感染前6天接种疫苗具有预防作用。
英文摘要
We constructed liposomes vaccines, in α-GalCe, an activated substance in NKT cell was inserted into the bilayers of phospholipid liposome capsules, and T cell epitopes derived from Japanese cedar pollen was included and attached to the surface of CTL epitopes. We examined IFV titers in the model mouse infected by influenza virus and sensitized by Japanese cedar pollen. In results, the administration of the vaccines for 6 days before the infection showed the prophylactic effects.
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福冨友馬,谷口正実,今野哲,西村正治,大矢幸弘,吉田幸一,岡田千春,高橋清,中村裕之,秋山一男,赤澤晃
DOI:
10.1016/j.anai.2011.10.013
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2012-02-01
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柴田亜樹,人見嘉哲,神林康弘,日比野由利,朝倉大貴,三苫純子,山崎政美,大滝直人,林宏一,大西孝司,相良多喜子,中村裕之
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