Determination and molecular and genetic marker in the allergy produced by RS virus infection and its prevention

RS病毒感染引起的过敏反应的测定、分子遗传标记及其预防

• 批准号: 20390170
• 负责人: NAKAMURA Hiroyuki
• 金额: $ 11.65万
• 依托单位: Kanazawa University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2008
• 资助国家: 日本
• 起止时间: 2008 至 2010
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20390170/
• 关键词: アレルギー; RSウイルス; ワクチン; S糖タンパク遺伝子; CpGモチーフ; 喘息; 予防; Th2サイトカイン; CdGモチーフ; 遺伝子; 分子疫学

This study aimed to clarify the involvement of RS virus in allergic diseases and develop preventive methods by determining the molecular and genetic marker in it. Animal experiments and molecular epidemiology determined Th2 cytokines, LR4 and CD4 as the markers. DNA vaccine containing S glycoprotein gene was found to lead to the inactivation of the markers, subsequently resulting in the efficient preventive agents.

本研究旨在通过检测RS病毒在变应性疾病中的分子和遗传标记，阐明RS病毒在变应性疾病中的作用，并制定相应的预防措施。动物实验和分子流行病学确定Th2细胞因子、LR4和CD4为标志物。发现含有S糖蛋白基因的DNA疫苗可导致标记物失活，从而产生有效的预防剂。

项目成果

A prospective naturalistic multicenter study of intravenous medications in behavioral emergencies : haloperidol versus flunitrazepam. Psychiatry Research.

行为紧急情况下静脉注射药物的前瞻性自然多中心研究：氟哌啶醇与氟硝西泮。

• 发表时间: 2009
• 期刊: Psychiatry Research. (in press)
• 作者: Hatta K;Nakamura M;Yoshida K;Hamakawa H;Wakejima T;Nishimura T;Furuta K;Kawabata T;Hirata T;Usui C;Nakamura H;Sawa Y.
• 通讯作者: Sawa Y.

能登半島地震による高齢者の健康被害-仮設住宅住民対象の調査から-

能登半岛地震对老年人健康造成的损害 - 来自临时住房居民的调查 -

• 发表时间: 2008
• 作者: 神林康弘;人見嘉哲;日比野由利;中村裕之
• 通讯作者: 中村裕之

Gene amplification of Myc and its coamplification with ERBB2 and EGFR in gallbladder adenocarcinoma.

• 发表时间: 2009
• 期刊: Anticancer research
• 影响因子: 2
• 作者: A. Ooi;Shioto Suzuki;K. Nakazawa;J. Itakura;I. Imoto;Hiroyuki Nakamura;Y. Dobashi

JAST study group : Difference in early prediction of antipsychotic non-response between risperidone and olanzapine in the treatment of acute-phase schizophrenia.

JAST研究组：利培酮和奥氮平治疗急性期精神分裂症抗精神病药物无反应的早期预测差异。

• 发表时间: 2011
• 期刊: Schizophr Res. 128
• 作者: Hatta K;Otachi T;Sudo Y;Hayakawa T;Ashizawa Y;Takebayashi H;Hayashi N;Hamakawa H;Ito S;Nakase R;Usui C;Nakamura H;Hirata T;Sawa Y
• 通讯作者: Sawa Y

The association of sense of coherence and coping profile with stress among research park city workers in Japan.

日本研究园区城市工作人员的一致性感和应对方式与压力的关联。

• 发表时间: 2009
• 期刊: Ind Health. 47(6)
• 作者: Tomotsune Y;Sasahara S;Umeda T;Hayashi M;Usami K;Yoshino S;Kageyama T;Nakamura H;Matsuzaki I
• 通讯作者: Matsuzaki I