The new bone regeneraition method for the implant with mesenchymal stem cell

我们更强烈地希望扩大适应病例和缩短骨结合种植体治疗的治疗周期。近年来再生医学技术的发展使单纯性骨缺损的骨再生成为可能。因此，我们有兴趣使用这种再生医学科学的前沿技术来扩大颌骨体积。本研究通过动物实验，探讨骨髓间充质干细胞（MSC）和富血小板血浆（PRP）联合应用对种植体周围骨缺损的修复效果。首先，建立了Beagle犬骨髓间充质干细胞的培养方法和PRP的制备工艺。实验结果表明，MSC和PRP联合应用于实验性下颌骨缺牙区或牙槽骨周围骨缺损，有可能促进骨再生。表明新型交互性多孔羟基磷灰石可作为骨再生支架材料

we are more strongly hoping for the expansion of the adaptation case and shortening of the treatment period of osseointegrated implant treatment. The development of the recent remarkable regenerative medical technology comes possible about the bone regeneration for simple bone defect. Therefore, we interested in using the frontier technology of this regenerative medical science for the expansion of the jaw bone volume. We were examined about which the regenerative medical technology were effective for the bone defect around implant with mesenchymal stem cell (MSC) and Platelet-rich plasma (PRP) in animal study. First, we established the technique about the way of the cultivation of the MSC and refining process of PRP in beagle dog. We had results that it was possible to promote the bone regeneration by using the MSC and PRP in experimental bone defect at mandibular edentulous area, or around the imaplant. And it was indicated that new interactive porous hydroxyapatite was useful as a scafold of bone regeneration