The new bone regeneraition method for the implant with mesenchymal stem cell

我们更希望骨结合种植体治疗适应病例的扩大和治疗周期的缩短。近年来再生医学技术的发展使单纯性骨缺损的骨再生成为可能。因此，我们有兴趣利用这一再生医学的前沿技术来扩大颌骨体积。通过动物实验，探讨了间充质干细胞（MSC）和富血小板血浆（PRP）两种再生医学技术对移植体周围骨缺损的治疗效果。首先，我们建立了比格犬骨髓间充质干细胞的培养方法和PRP的精制工艺。我们的研究结果表明MSC和PRP可以促进下颌无牙区或种植体周围实验性骨缺损的骨再生。结果表明，新型多孔羟基磷灰石可作为骨再生的支架材料

we are more strongly hoping for the expansion of the adaptation case and shortening of the treatment period of osseointegrated implant treatment. The development of the recent remarkable regenerative medical technology comes possible about the bone regeneration for simple bone defect. Therefore, we interested in using the frontier technology of this regenerative medical science for the expansion of the jaw bone volume. We were examined about which the regenerative medical technology were effective for the bone defect around implant with mesenchymal stem cell (MSC) and Platelet-rich plasma (PRP) in animal study. First, we established the technique about the way of the cultivation of the MSC and refining process of PRP in beagle dog. We had results that it was possible to promote the bone regeneration by using the MSC and PRP in experimental bone defect at mandibular edentulous area, or around the imaplant. And it was indicated that new interactive porous hydroxyapatite was useful as a scafold of bone regeneration