The new bone regeneraition method for the implant with mesenchymal stem cell

间充质干细胞植入物骨再生新方法

• 批准号: 13557167
• 负责人: AKAGAWA Yasumasa
• 金额: $ 7.1万
• 依托单位: HIROSHIMA UNIVERSITY
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2001
• 资助国家: 日本
• 起止时间: 2001 至 2002
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-13557167/
• 关键词: Mesenchymal stem cell; Imalant; Bone regeneration; Platelet-rich-plasma; Poly-lacted acid; Resorvable membrane; Interconective porous hydroxyapatite; 再生療法; 自己肝細胞; 自己血小板濃縮血漿; 自己幹細胞

we are more strongly hoping for the expansion of the adaptation case and shortening of the treatment period of osseointegrated implant treatment. The development of the recent remarkable regenerative medical technology comes possible about the bone regeneration for simple bone defect. Therefore, we interested in using the frontier technology of this regenerative medical science for the expansion of the jaw bone volume. We were examined about which the regenerative medical technology were effective for the bone defect around implant with mesenchymal stem cell (MSC) and Platelet-rich plasma (PRP) in animal study. First, we established the technique about the way of the cultivation of the MSC and refining process of PRP in beagle dog. We had results that it was possible to promote the bone regeneration by using the MSC and PRP in experimental bone defect at mandibular edentulous area, or around the imaplant. And it was indicated that new interactive porous hydroxyapatite was useful as a scafold of bone regeneration

我们更强烈地希望扩大适应病例和缩短骨结合种植体治疗的治疗周期。近年来再生医学技术的发展使单纯性骨缺损的骨再生成为可能。因此，我们有兴趣使用这种再生医学科学的前沿技术来扩大颌骨体积。本研究通过动物实验，探讨骨髓间充质干细胞（MSC）和富血小板血浆（PRP）联合应用对种植体周围骨缺损的修复效果。首先，建立了Beagle犬骨髓间充质干细胞的培养方法和PRP的制备工艺。实验结果表明，MSC和PRP联合应用于实验性下颌骨缺牙区或牙槽骨周围骨缺损，有可能促进骨再生。表明新型交互性多孔羟基磷灰石可作为骨再生支架材料

项目成果

Toshihide, Takekoshi: "An experimental study on acceleration of bone regeneration with platelet-rich plasma of bone defect around dental implant"J.Hiroshima Univ.Dent.Soc.. 35. 33-48 (2003)

Toshihide、Takekoshi：“利用富含血小板的血浆促进牙种植体周围骨缺损的骨再生的实验研究”J.Hiroshima Univ.Dent.Soc.. 35. 33-48 (2003)

Ryuji, Hosokawa et al.: "The mechanism of acceleration on tissue regeneration with PRP (Platelet-rich plasma)"Dental Outlook. 100. 1230-1243 (2002)

Ryuji、Hosokawa 等人：“PRP（富血小板血浆）加速组织再生的机制”Dental Outlook。

細川隆司: "PRP(plate-rich-plasma)による組織再生促進のメカニズムー臨床への展開と今後の課題ム"歯界展望. 100. 1230-1243 (2002)

Takashi Hosokawa：“PRP（富板血浆）促进组织再生的机制 - 临床发展和未来挑战”Dental Perspectives 100。1230-1243（2002）。

細川隆司: "PRP(plate-rich-plasma)の臨床応用"広大歯誌. 34. 111-113 (2002)

Takashi Hosokawa：“PRP（富板血浆）的临床应用”广岛大学牙科杂志 34. 111-113 (2002)。

竹腰利英: "インプラント周囲骨欠損に対する多血小板血漿の骨再生促進効果に関する実験的研究"広大歯誌. 35. 33-48 (2003)

Toshihide Takekoshi：“富含血小板血浆对种植体周围骨缺损的骨再生促进作用的实验研究”广岛大学牙科杂志 35. 33-48 (2003)。