The molecular basis of association mechanism between Alzheimer's disease and tooth loss

为了阐明牙齿缺失与阿尔茨海默病S病的关系，我们利用阿尔茨海默病S模型小鼠，比较了拔牙组和完好组。结果，我们发现牙齿缺失并不影响Aβ的积累。而拔牙组锥体细胞数量较完整组减少。行为学测试结果显示，牙齿脱落会降低学习记忆能力。我们可能认为牙齿缺失通过另一条众所周知的淀粉样级联反应影响AD的发病机制或AD的发病。

To elucidate the association between tooth loss and Alzheimer ’ s disease, we compared tooth extracted group with tooth intact group using Alzheimer ’ s model mice. As a result, we found that tooth loss did not influence the accumulation of Aβ. However, the number of pyramidal cell of tooth extracted group is decreased compared with tooth intact group. And, the results of behavioral test revealed that tooth loss deteriorates the learning and memory ability. We could suggest that tooth loss affect the AD pathogenesis or AD onset through another pathway of well-known amyloid cascade.