Basik research of anti-angiogenesis and apoptosis targeted therapy

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We compared the anti-tumor effects of CPT-11 and vessel density as a angiogenesis index, and apoptotic index of tumor between two different regimens groups, 100 mg/kg once a week (day 1 and 8) and 20 mg/kg five times a week (day 1, 2, 3, 4, 5, 8, 9. 10, 11, and 12) for two weeks. Vessel density was significantly less and the apoptotic index was significantly greater in tumors treated with 20 mg/kg 5 times per week of CPT -11 than those with 100 mg/kg once a week treatment. The combination effect of CPT-11 and anti-VEGF (vascular endothelial growth factor) antibody was observed only in tumors treated with 20 mg/kg 5 times per week of CPT -11. These effect were observed more remarkably in cachexia model.These results suggest that divided low dose chemotherapy may induce the anti-angiogenesis as well as apoptosis. It will be applicable for patients with far advanced cancer, because these effect were observed much greater in cachexia model