Basik research of anti-angiogenesis and apoptosis targeted therapy

抗血管生成和凋亡靶向治疗的基础研究

• 批准号: 15591392
• 负责人: TAKAHASHI Yutaka
• 金额: $ 1.34万
• 依托单位: Kanazawa University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2003
• 资助国家: 日本
• 起止时间: 2003 至 2004
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-15591392/
• 关键词: Anti-angiogenesis; Apoptosis; CRT-11; Low dose chemotherapy; Cachexia; CPT-11; 低用量; cyclophophamide

We compared the anti-tumor effects of CPT-11 and vessel density as a angiogenesis index, and apoptotic index of tumor between two different regimens groups, 100 mg/kg once a week (day 1 and 8) and 20 mg/kg five times a week (day 1, 2, 3, 4, 5, 8, 9. 10, 11, and 12) for two weeks. Vessel density was significantly less and the apoptotic index was significantly greater in tumors treated with 20 mg/kg 5 times per week of CPT -11 than those with 100 mg/kg once a week treatment. The combination effect of CPT-11 and anti-VEGF (vascular endothelial growth factor) antibody was observed only in tumors treated with 20 mg/kg 5 times per week of CPT -11. These effect were observed more remarkably in cachexia model.These results suggest that divided low dose chemotherapy may induce the anti-angiogenesis as well as apoptosis. It will be applicable for patients with far advanced cancer, because these effect were observed much greater in cachexia model

我们比较了CPT-11的抗肿瘤作用和作为血管生成指数的血管密度，以及两个不同方案组之间的肿瘤凋亡指数，100 mg/kg每周一次（第1和8天）和20 mg/kg每周五次（第1、2、3、4、5、8、9天）。10、11和12）两周。与每周一次100 mg/kg CPT-11治疗的肿瘤相比，每周5次20 mg/kg CPT-11治疗的肿瘤中血管密度显著更小，凋亡指数显著更大。仅在用20 mg/kg CPT-11每周5次处理的肿瘤中观察到CPT-11和抗VEGF（血管内皮生长因子）抗体的联合作用。上述结果提示，分次小剂量化疗在诱导细胞凋亡的同时，还可能具有抑制血管生成的作用。它将适用于患有晚期癌症的患者，因为在恶病质模型中观察到的这些效果要大得多

项目成果

Zhang B, Takahashi Y, et al.: "Beta-catenin and ras oncogenes detect most human colorectal cancers"Clin Cancer Res. 9・8. 3073-3079 (2003)

张 B、高桥 Y 等：“β-连环蛋白和 ras 癌基因可检测大多数人类结直肠癌”Clin Cancer Res. 9・8 (2003)。

Takahashi Y, et al.: "The angiogenic switch of human colon cancer occurs simultaneous to initiation of invasion."Oncology Rep. 10・1. 9-13 (2003)

Takahashi Y 等人：“人类结肠癌的血管生成开关与侵袭的开始同时发生。”Oncology Rep. 10・1 (2003)。

Angiogenesis of AFP producing gastric carcinoma: correlation with frequent liver metastasis and its inhibition by anti-AFP antibody.

• DOI: 10.3892/or.11.4.809
• 发表时间: 2004-04
• 期刊: Oncology reports
• 影响因子: 4.2
• 作者: Yutaka Takahashi;T. Ohta;M. Mai

Takahashi Y, et al.: "A pilot study of low dose, divided MTD of CPT-11 on 21 consecutive patients with metastatic"Surgery Todya. (in press).

Takahashi Y 等人：“对 21 名连续转移性患者进行低剂量、分开的 CPT-11 MTD 的初步研究”Surgery Todya。

Takahashi Y, et al.: "Angiogenesis of AFP producing gastric carcinoma : Correlation with frequent liver metastasis."Oncology Rep. (in press).

Takahashi Y 等人：“产生 AFP 的胃癌的血管生成：与频繁肝转移的相关性”。肿瘤学代表（正在出版）。