Study of the optimal dose of some chemotherapeutic drugs forenhancement of cancer specific immunotherapy by dendritic cell
Study of the optimal dose of some chemotherapeutic drugs forenhancement of cancer specific immunotherapy by dendritic cell
批准号:
19591536
负责人:
TAKAHASHI Yutaka
金额:
$2.75万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2007
资助国家:
日本
项目状态:
已结题
起止时间:
2007 至 2008
中文摘要
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英文摘要
樹状細胞を用いた癌特異免疫療法において、併用する各種抗癌剤の適量について検討した。その結果、抗癌剤単独では最も効果が高いとされているMTD (maximumtolerated dose)よりも低い濃度で、併用効果が高いことが判明した。またその時のマウスの骨髄抑制を検討したところ、軽度から中等度であった。以上から、樹状細胞療法と抗癌剤の併用を臨床応用する場合は、軽度の骨髄抑制を指標として抗癌剤の量を調節することが重要であることが示唆された。ombination in VEGF-targeted and-non-targeted anti-angiogenesis therapya。
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Inhibition of GSK3|*beta*|activity attenuates proliferation of humancolon cancer cells in rodents
抑制 GSK3|*beta*|活性可减弱啮齿动物中人类结肠癌细胞的增殖
DOI:
--
发表时间:
2007
期刊:
CancerScience 98
影响因子:
--
作者:
[Shakoori A, Mai W Miyashita K, YasumotoK, Takahashi Y, Ooi A, Kawakami K,Minamoto T.]
通讯作者:
Kawakami K,Minamoto T.
DOI:
10.2325/jbcs.14.414
发表时间:
2007-01-01
期刊:
Breast cancer (Tokyo, Japan)
影响因子:
--
作者:
[Kitakata, Hidekazu, Yasumoto, Kazuo, Takahashi, Yutaka]
通讯作者:
Takahashi, Yutaka
Tumor dormancy therapy
肿瘤休眠治疗
DOI:
--
发表时间:
2008
期刊:
日本保険医学会雑誌 106
影响因子:
--
作者:
[林 啓一, 柴田 近, 林啓一, 高橋豊, 高橋豊]
通讯作者:
高橋豊
In vivo combination therapy of anti-VEGF antibody and DFMO on VEGF-dependent and -independent tumors : Significance of the combination in VEGF-targeted and-non-targeted anti-angiogenesis therapy
抗 VEGF 抗体和 DFMO 对 VEGF 依赖性和非依赖性肿瘤的体内联合治疗:联合治疗在 VEGF 靶向和非靶向抗血管生成治疗中的意义
DOI:
--
发表时间:
期刊:
Recent advance of metastaticgastrointestinal cancers (in press)
影响因子:
--
作者:
[Shakoori A, Takahashi Y, et al, Takahashi Y and Nishioka K]
通讯作者:
Takahashi Y and Nishioka K
RANDOMIZED PHASE IICLINICAL TRIAL OF TAILORED IRINOTECAN(CPT-11) PLUS S-1 VERSUS S-1 IN PATIENTSWITH ADVANCED OR RECURRENT GASTRICCARCINOMA AS THE FIRST-LINE CHEMOTHERAPY CLINICAL TRIAL OF TAILORED IRINOTECAN (CPT-11) PLUS S-1 VERSUS S-1 IN PATIENTS WITH
特制伊立替康 (CPT-11) 加 S-1 与 S-1 在晚期或复发性胃癌患者中的随机 I 期临床试验 作为一线化疗特制伊立替康 (CPT-11) 加 S-1 与 S-1 的临床试验
DOI:
--
发表时间:
2008
期刊:
影响因子:
--
作者:
[Takahashi Y, et.al.]
通讯作者:
et.al.
共 12 条
System Dynamics Application to Developing Management Strategies
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批准号:17K03955
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项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$2.33万
-
财政年份:2017
-
负责人:TAKAHASHI Yutaka
-
依托单位:
Geotectonic analyses of the Hidaka Collision Zone, northern Japan, based on zircon U-Pb ages
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批准号:16K05585
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.91万
-
财政年份:2016
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负责人:TAKAHASHI Yutaka
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依托单位:
Modeling and Performance Analysis of AMI in Smart Grid
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批准号:25540147
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项目类别:Grant-in-Aid for Challenging Exploratory Research
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资助金额:$2.33万
-
财政年份:2013
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负责人:TAKAHASHI Yutaka
-
依托单位:
Research on low spin-damping magnetic materials for the power-efficient spin-controlled devices
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批准号:23560384
-
项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$3.33万
-
财政年份:2011
-
负责人:TAKAHASHI Yutaka
-
依托单位:
The regulatory mechanisms of brown adipose tissue by novel adipokine chemerin
-
批准号:23659477
-
项目类别:Grant-in-Aid for Challenging Exploratory Research
-
资助金额:$2.33万
-
财政年份:2011
-
负责人:TAKAHASHI Yutaka
-
依托单位:
Development of novel brachytherapy technique for various tumor sited that had never been treated
-
批准号:22791194
-
项目类别:Grant-in-Aid for Young Scientists (B)
-
资助金额:$2.66万
-
财政年份:2010
-
负责人:TAKAHASHI Yutaka
-
依托单位:
The mechanism and overcome of resistance to anti-VEGF antibody, bevacizumab in colon cancer
-
批准号:22591478
-
项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$2.91万
-
财政年份:2010
-
负责人:TAKAHASHI Yutaka
-
依托单位:
Development and application of Fiber Reinforced Composites (FRC) to removable acrylic resin dentures.
-
批准号:21592485
-
项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$2.91万
-
财政年份:2009
-
负责人:TAKAHASHI Yutaka
-
依托单位:
Therapeutic application of growth hormone and IGF-I for nonalcoholic steatohepatitis
-
批准号:20200079
-
项目类别:Grant-in-Aid for Scientific Research on Innovative Areas (Research a proposed research project)
-
资助金额:$19.05万
-
财政年份:2008
-
负责人:TAKAHASHI Yutaka
-
依托单位:
High speed magnetic recording in semiconductor/ferromagnetic thin films by optically-aligned spin injection
-
批准号:20560315
-
项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$2.91万
-
财政年份:2008
-
负责人:TAKAHASHI Yutaka
-
依托单位:
Improving accuracy of Iodine-125 permanent implant brachytherapy for prostate cancer based on real time in vivo dosimetry
-
批准号:19790909
-
项目类别:Grant-in-Aid for Young Scientists (B)
-
资助金额:$1.43万
-
财政年份:2007
-
负责人:TAKAHASHI Yutaka
-
依托单位:
Identification and analysis of two novel chemokines that regulate glucose and lipid metabolism
-
批准号:19591077
-
项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$2.91万
-
财政年份:2007
-
负责人:TAKAHASHI Yutaka
-
依托单位:
Development for Fiber Reinforced Composites (FRC) and its application to removable acrylic resin dentures
-
批准号:19592274
-
项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$2.91万
-
财政年份:2007
-
负责人:TAKAHASHI Yutaka
-
依托单位:
Research on Large-Scale Distributed Content Discovery and Delivery Networks
-
批准号:18360181
-
项目类别:Grant-in-Aid for Scientific Research (B)
-
资助金额:$11.01万
-
财政年份:2006
-
负责人:TAKAHASHI Yutaka
-
依托单位:
Tailored dose chemotherapy and the relationship with PK.
-
批准号:17591382
-
项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$1.6万
-
财政年份:2005
-
负责人:TAKAHASHI Yutaka
-
依托单位:
Basik research of anti-angiogenesis and apoptosis targeted therapy
-
批准号:15591392
-
项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$1.34万
-
财政年份:2003
-
负责人:TAKAHASHI Yutaka
-
依托单位:
Electron spin manipulation in coupled multiple quantum wells for quantum computing
-
批准号:14550001
-
项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$1.6万
-
财政年份:2002
-
负责人:TAKAHASHI Yutaka
-
依托单位:
Development of a Content Delivery Network for Next Generation and its Performance Analysis
-
批准号:14380176
-
项目类别:Grant-in-Aid for Scientific Research (B)
-
资助金额:$9.41万
-
财政年份:2002
-
负责人:TAKAHASHI Yutaka
-
依托单位:
Basic research for the establishment of anti-angiogenic therapy by antibody to VEGF
-
批准号:13671288
-
项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$1.73万
-
财政年份:2001
-
负责人:TAKAHASHI Yutaka
-
依托单位:
Research on Performance Evaluation of Multimedia Traffic towards Development of Next Generation Internet
-
批准号:12680414
-
项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$2.37万
-
财政年份:2000
-
负责人:TAKAHASHI Yutaka
-
依托单位:
海外基金