Basic research for the establishment of anti-angiogenic therapy by antibody to VEGF
Basic research for the establishment of anti-angiogenic therapy by antibody to VEGF
批准号:
13671288
负责人:
TAKAHASHI Yutaka
金额:
$1.73万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2001
资助国家:
日本
项目状态:
已结题
起止时间:
2001 至 2002
中文摘要
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英文摘要
I examined the effect of antibody to VEGF on two cell lines, KKLS and KM12sm : I have previously reported that VEGF upregulated in the orthotopic implantation of KKLS, and bFGF did in that of KM12sm. Antibody to VEGF inhibited the liver metastasis of KKLS, while did not that of KM12sm. Moreover, mRNA of other angiogenic factors such as bFGF did not upregulate in KKLS after therapy of antibody to VEGF therapy.From these results, it is suggested that antibody to VEGF should be given to the tumor whose VEGF upregulated and we can give it for a long time.
期刊论文(8)
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Takahashi Y, Ellis LM, Mai M.: "The angiogenic switch of human colon cancer occurs simultaneous to initiation of invasion"Oncology Report. 10. 9-13 (2003)
Takahashi Y、Ellis LM、Mai M.:“人类结肠癌的血管生成开关与侵袭的开始同时发生”肿瘤学报告。
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Takahashi Y, et al.: "The angiogenic switch of human colon cancer occurs simultaneous to intiation of invasion"Oncology Report. 10. 9-13 (2003)
Takahashi Y 等人:“人类结肠癌的血管生成开关与侵袭的开始同时发生”肿瘤学报告。
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Takahashi Y. et al.: "The angiogenic switch of human colon cancer occurs simultaneous to initiation of invasion"Onclolgy Report. 10. 9-13 (2003)
Takahashi Y.等人:“人类结肠癌的血管生成开关与侵袭的开始同时发生”肿瘤学报告。
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Takahashi Y, Kitadai Y, Ellis LM, Bucana CD, Fidler IJ, Mai M.: "Multiparametric in Situ mRNA hybridization analysis of gastric biopsies predict lymph node metastasis in patients with gastric carcinoma."Japanese Journal of Cancer Research. 93. 1258-1265 (
Takahashi Y、Kitadai Y、Ellis LM、Bucana CD、Fidler IJ、Mai M.:“胃活检的多参数原位 mRNA 杂交分析可预测胃癌患者的淋巴结转移。”日本癌症研究杂志。
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Takahashi Y. et al.: "Multiparametric in situ mRNA hybridization analysis of gastric biopsies predicts lymph node metastasis"Japanese Journal of Cancer Research. 93. 1258-1265 (2002)
Takahashi Y.等人:“胃活检的多参数原位mRNA杂交分析预测淋巴结转移”日本癌症研究杂志。
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