Development of novel brachytherapy technique for various tumor sited that had never been treated

开发针对从未治疗过的各种肿瘤部位的新型近距离放射治疗技术

• 批准号: 22791194
• 负责人: TAKAHASHI Yutaka
• 金额: $ 2.66万
• 依托单位: Osaka University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2010
• 资助国家: 日本
• 起止时间: 2010 至 2011
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22791194/
• 关键词: 小線源治療; 腔内モールド照射; スキルス胃がん

The purpose of this study was to develop the novel brachytherapy technique for various tumors that had never been treated including highly malignant schirrhous stomach carcinoma. First, novel applicator was designed so that the applicator can be swelled with great flexibility along the stomach wall. The dose measurement with this applicator was performed using film or BangGel. We found that film measurement was not suitable due to the response heterogeneity in the film. On the other hand, 3D gel dosimetry was found to be suitable owing to high spatial resolution and the dose around the stomach was rapidly fallen off. Further simulation study to examine the appropriate source position or radionuclide is required for appropriate treatment.

本研究的目的是开发新的近距离放疗技术，用于治疗各种从未治疗过的肿瘤，包括高度恶性schirrous胃癌。首先，设计了一种新颖的施药器，使施药器可以沿胃壁灵活膨胀。使用薄膜或BangGel进行剂量测量。我们发现，由于薄膜的响应不均匀性，薄膜测量不适合。另一方面，由于空间分辨率高，胃周围的剂量迅速下降，因此发现3D凝胶剂量法是合适的。需要进一步的模拟研究，以检查适当的源位置或放射性核素，以便进行适当的处理。

项目成果

Semi-independent plan verification m ethod for high-dose-rate intracavitary brachytherapy using benchmark plan

使用基准计划的高剂量率腔内近距离治疗的半独立计划验证方法

• 发表时间: 2011
• 作者: Takahashi Y;Koizumi M;Sumida I et a l
• 通讯作者: Sumida I et a l

Semi-independent plan verification method for high-dose-rate intracavitary brachytherapy using benchmark plan

基于基准计划的高剂量率腔内近距离治疗的半独立计划验证方法

• 发表时间: 2011
• 作者: Yutaka Takahashi;et al
• 通讯作者: et al

Homogeneity of GAFCHROMIC EBT2 film among different lot numbers.

• DOI: 10.1120/jacmp.v13i4.3763
• 发表时间: 2012-07-05
• 期刊: Journal of applied clinical medical physics
• 影响因子: 2.1
• 作者: Mizuno H;Takahashi Y;Tanaka A;Hirayama T;Yamaguchi T;Katou H;Takahara K;Okamoto Y;Teshima T
• 通讯作者: Teshima T