Therapeutic application of growth hormone and IGF-I for nonalcoholic steatohepatitis
Therapeutic application of growth hormone and IGF-I for nonalcoholic steatohepatitis
批准号:
20200079
负责人:
TAKAHASHI Yutaka
金额:
$19.05万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research on Innovative Areas (Research a proposed research project)
财政年份:
2008
资助国家:
日本
项目状态:
已结题
起止时间:
2008 至 2010
中文摘要
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英文摘要
We have reported a case of adult growth hormone deficiency (AGHD) accompanied with nonalcoholic steatohepatitis (NASH), in which GH replacement therapy drastically ameliorated NASH. Then, we have analyzed the prevalence of NAFLD/NASH in the patients with AGHD and found that NAFLD/NASH are frequently observed in AGHD and GH replacement therapy improved these conditions. Based on these results, we explored whether GH or IGF-I ameliorates general NASH using animal model. Interestingly, we found that GH particularly IGF-I ameliorated steatosis and fibrosis in the liver of the animal model, implicating a therapeutic application of IGF-I for general NASH.
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Diverse splicing abnormality caused by a homozygous mutation in the thiazide-sensitive sodium-chloride cotransporter gene in a patient with Gitelman's syndrome
吉特尔曼综合征患者噻嗪类敏感的氯化钠协同转运蛋白基因纯合突变导致多种剪接异常
DOI:
--
发表时间:
2008
期刊:
Am J Kidney Dis 51(6)
影响因子:
--
作者:
[Iida, Nozu K, Takahashi Y, Okimura Y, Kaji H, Matsuo M, Chihara K]
通讯作者:
Chihara K
Efficacy and safety of individualized growth hormone treatment in adult Japanese patients with growth hormone deficiency.
日本成年生长激素缺乏症患者个体化生长激素治疗的有效性和安全性。
DOI:
--
发表时间:
2008
期刊:
Growth Hormone & IGF Research 18
影响因子:
--
作者:
[Chihara K, et al]
通讯作者:
et al
先端巨大症における高トリグリセライド血症は耐糖能と血清GH値に関連する
肢端肥大症患者的高甘油三酯血症与葡萄糖耐量和血清 GH 水平相关
DOI:
--
发表时间:
2008
期刊:
影响因子:
--
作者:
[Kaji H, Iida K, Takahashi Y, Okimura Y, Chihara K, Daisuke Yamamoto, Yutaka Takabashi, Hidesuke Kaji, Hisashi Urushihara, Kazuo Chihara, Mari Imanaka, Michiko Takahashi, 千原和夫, 飯田啓二, 島津章, 飯田啓二, 飯田啓二, 宮内章光, 福岡秀規, 今中真理, 竹野亮子, 杉山裕香, 芝原優美, 杉山裕香ら, 芝原優美ら, 福岡秀規]
通讯作者:
福岡秀規
脳神経外科エキスパート 間脳下垂体
神经外科专家 间脑垂体
DOI:
--
发表时间:
2008
期刊:
影响因子:
--
作者:
[Kaji H, Iida K, Takahashi Y, Okimura Y, Chihara K, Daisuke Yamamoto, Yutaka Takabashi, Hidesuke Kaji, Hisashi Urushihara, Kazuo Chihara, Mari Imanaka, Michiko Takahashi, 千原和夫, 飯田啓二, 島津章, 飯田啓二, 飯田啓二, 宮内章光, 福岡秀規, 今中真理, 竹野亮子, 杉山裕香, 芝原優美, 杉山裕香ら, 芝原優美ら, 福岡秀規, 今中真理, 西澤衡, 山本大輔, 今中真理ら, 千原和夫, 高橋裕, Elizabeth Henny Herningtyas, 今中真理, 池下伸子, 福岡秀規, 高橋路子, Elizabeth Henny Herningtyas, 福岡秀規, 千原和夫, K. Iida, H. Fukuoka, 高橋 裕, 高橋 裕, A Shimatsu, 千原和夫]
通讯作者:
千原和夫
DOI:
10.1016/j.ghir.2007.12.001
发表时间:
2008-08-01
期刊:
GROWTH HORMONE & IGF RESEARCH
影响因子:
1.4
作者:
[Chihara, K., Kato, Y., Shimatsu, A.]
通讯作者:
Shimatsu, A.
共 110 条
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The mechanism and overcome of resistance to anti-VEGF antibody, bevacizumab in colon cancer
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Identification and analysis of two novel chemokines that regulate glucose and lipid metabolism
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Development for Fiber Reinforced Composites (FRC) and its application to removable acrylic resin dentures
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Research on Large-Scale Distributed Content Discovery and Delivery Networks
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Tailored dose chemotherapy and the relationship with PK.
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Electron spin manipulation in coupled multiple quantum wells for quantum computing
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Development of a Content Delivery Network for Next Generation and its Performance Analysis
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Research on Performance Evaluation of Multimedia Traffic towards Development of Next Generation Internet
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