Fundamental Network of Genes and Proteins for Bacterial Cell Growth

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Towards elucidation of fundamental networks of genes and proteins supporting growth of bacterial cells, we analyzed two model bacteria, Bacillus subtilis and Escherichia coli, using new methodologies, such as ChIP-chip analysis using a tiling chip and protein complex analysis using mass spectrometry. As the results, we obtained many new findings concerning new functions of essential genes, functional network of essential proteins, transcriptional regulatory network by transcription factors and nucleoid proteins, cell cycle regulation by nucleoid protein, and metabolome dynamics.