Mechanobiology in tissue formation and robotic engineering of functional tissues

组织形成的力学生物学和功能组织的机器人工程

• 批准号: 17076012
• 负责人: MATSUDA Takehisa
• 金额: $ 44.1万
• 依托单位: Kanazawa Institute of Technology (2006-2009)Kyushu University (2005)
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research on Priority Areas
• 财政年份: 2005
• 资助国家: 日本
• 起止时间: 2005 至 2009
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-17076012/
• 关键词: メカノバイオロジー; メカノアクティブ骨格基材; セルディスペンスロボット; メカノタクシス; 生体材料; 再生医学; 細胞・組織; マイクロナノデバイス; 生物物理; セルディスペンスロボ

echnologies of robotics-assisted processing for functional artificial tissue have been developed : manipulation robotics for the controlled spatial deposition of cells, for the automatic fabrication of functional tissues, for controlled mechanical loading to induce tissue formation, and for the design and construction of mechanoactive scaffolds matching with the intrinsic mechanical property of native tissues. Methodologies for automatic processing and fabrication of the mechanoactive tissue-engineering matrix and scaffold have been established.

已经开发了用于功能性人造组织的机器人辅助处理技术：用于细胞的受控空间沉积、用于功能性组织的自动制造、用于诱导组织形成的受控机械加载以及用于与天然组织的固有机械性质匹配的机械活性支架的设计和构造的操纵机器人。已经建立了用于机械活性组织工程基质和支架的自动化处理和制造的方法。

项目成果

In situ harvesting of adhered target cells using thermoresponsive substrate under a microscope: principle and instrumentation.

• DOI: 10.1016/j.jbiotec.2008.01.015
• 发表时间: 2008-04
• 期刊: Journal of biotechnology
• 影响因子: 4.1
• 作者: H. Takamatsu;S. Uchida;T. Matsuda

Cartilaginous tissue formation using a mechano-active scaffold and dynamic compressive stimulation

使用机械活性支架和动态压缩刺激形成软骨组织

• 发表时间: 2008
• 期刊: Journal of Biomaterials Science, Polymer Edition 19(1)
• 作者: Y.M. Jung;S.H. Kim;S-H. Kim;Y.H. Kim;J. Xie;T. Matsuda;G.G. Min
• 通讯作者: G.G. Min

New Technique of Seeding Chondrocytes into Microporous Poly(L-lactide-co-e -caprolactone) Sponge by Cyclic Compression Force-Induced Suction

循环压缩力诱导吸力将软骨细胞接种到微孔聚(L-丙交酯-co-己内酯)海绵中的新技术

• 发表时间: 2006
• 期刊: Tissue Engineering 12(7)
• 作者: J. Xie;Y. Jung;S. Kim;K. Hyun;H. Young;*T. Matsuda
• 通讯作者: *T. Matsuda

Characterization of the cellular biomechanical responses caused on microprocessed substrates : effect of micropatterned cell adhesiveness and microelastici gradient.

微加工基底上引起的细胞生物力学反应的表征：微图案细胞粘附性和微弹性梯度的影响。

• 发表时间: 2006
• 期刊: Proceedings of the International Symposium on Micro-Nanomechatronics and Human Science (印刷中)
• 作者: S.Kidoaki;T.Matsuda
• 通讯作者: T.Matsuda

Photo-polymerized microarchitectural constructs prepared by microstereolithography (muSL)using liquid acrylate-end-capped trimethylene carbonate-based prepolymers.

使用液体丙烯酸酯封端的三亚甲基碳酸酯预聚物通过微立体光刻 (muSL) 制备光聚合微结构结构。

• 发表时间: 2005
• 期刊: Biomaterials 26(14)
• 作者: Kwon Il Keun;Matsuda Takehisa
• 通讯作者: Matsuda Takehisa