Tissue Engineering of Vascular Wall Reconstruction : Fundamentals & Application

美国国家心血管中心和威斯康星州大学开展的国际合作研究旨在加深对机械应力场下血管细胞类型的理解及其在血管和心脏等组织工程和人工器官中的潜在应用。在国家心血管中心，血管细胞类型包括内皮细胞和平滑肌细胞，它们已经暴露于流体动力学切应力和机械扩张，其已经研究了聚焦细胞骨架排列和表型改变。构建分级结构的杂交组织并植入犬动脉中。另一方面，密尔沃基心脏实现了内皮化。通过互访各自的研究所，交流信息、技术和方法，对双方正在进行的项目非常有用。

The international collaborative study between National Cardiovascular Center and University of Wisconsin have launched to deepen understanding of vascular cell types under mechanical stress field and its potential applications to tissue-engineered and artificial organs such as vascular vessels and hearts. At the National Cardiovascular Center, vascular cell types include endothelial cells and smooth muscle cells have been exposed to hydrodynamic sheer stress and mechanical distension, which have studied focusing cytoskeletal arrangement and phenotype alteration. Hierarchical structured hybrid tissues were constructed and impianted into canine arteries. On the other hand, endothelialization on Milwaukee Heart was achieved.Exchange of information, techniques and methodologies upon mutual visits to respective institutes were very useful fon conducting ongoing projects at both sides.