Development of Small-Diameter Artificial Graff via Multifaceted Appproaches

通过多方面的方法开发小直径人造格拉夫

• 批准号: 06557075
• 负责人: MATSUDA Takehisa
• 金额: $ 8.64万
• 依托单位: Research institution of National Cardiovascular Center
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (A)
• 财政年份: 1994
• 资助国家: 日本
• 起止时间: 1994 至 1996
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-06557075/
• 关键词: Artificial Graft; Neoarterial Regeneration; Scaffold; Matrix; Cytokine; セグメント化ポリウレタン; エキシマレーザ; 生体内リモデリング; ハイブリッド人工血管; 組織再構築

The development of small caliber artificial grafts has been long awaited in cardiovascular surgey. Minimal thrombus formation in an early implantation and rapid neoarterial regeneration and well-controlled morphogenesis in the following period are essential for vital replacement with diseased vessels. To this esd, we have taken multi-faceted approaches including scaffold design with excimer laser-directed controlled microporosity to provide compliance matching as well as transmural tissue ingrowth, metrix design and cytokine immobilization, both of which are designed to enhance endothelialization and neoarterial regeneration, and cellular engineering providing a hybrid tubular tissue with three-layred hierarchical structure biomimicking to the layring of natural vessels. Onece these disciplines were fully formulated into a design graft, such grafts undergo to remoldel themselves in vivo, producing a vascular tissues resembling that of natural vessel in terms of structure and function.

小口径人工血管的发展一直是心血管外科期待已久的课题。植入早期血栓形成最少，后续阶段新生动脉快速再生和良好控制的形态发生对于病变血管的重要置换至关重要。为此，我们采取了多方面的方法，包括用准分子激光定向控制的微孔结构设计支架，以提供顺应性匹配以及透壁组织向内生长，生物相容性设计和细胞因子固定，这两种设计都是为了增强内皮化和新生动脉再生，以及细胞工程学提供具有三层分层结构的混合管状组织，仿生天然血管的铺设。一旦这些学科被完全制定成一个设计的移植物，这种移植物经历重塑自己在体内，产生类似于天然血管的结构和功能的血管组织。

项目成果

K.doi,Y.Nakayama,T.Matsuda: "Novel compliant and Tissue-Permeable Microporous Polyurethare Vascular Prosthesis Fabricated Using and Excimer Laser Ablation Technique" Journal of Biomedical Materials Research. 31. 27-33 (1996)

K.doi，Y.Nakayama，T.Matsuda：“使用准分子激光烧蚀技术制造的新型顺应性和组织渗透性微孔聚氨酯血管假体”生物医学材料研究杂志。

土井 潔: "エキシマレーザにより微細加工した多孔質ポリウレタン小口径人工血管の開発:設計思想とプロトタイプデバイス" 人工臓器. 24. 190-194 (1995)

Kiyoshi Doi：“准分子激光微加工多孔聚氨酯小直径人造血管的开发：设计概念和原型装置”Artificial Organs。 24. 190-194 (1995)

N.Saito,T.Sugawara,T.Matsuda: "Synthesis and Hydrophilicity of Multifunctionally Hydroxylated Poly (acrylamides)" Macromolecules. 29. 313-319 (1996)

N.Saito、T.Sugarara、T.Matsuda：“多功能羟基化聚（丙烯酰胺）的合成和亲水性”大分子。

H.Kito,T.Matsuda: "Biocompatible Coatings for Laminal and Outer Surfaces of Small-Caliber-Artifical Grafts" Journal of Biomedical Materials Research. 30. 321-330 (1996)

H.Kito、T.Matsuda：“小口径人工移植物层状和外表面的生物相容性涂层”生物医学材料研究杂志。

N.Saito,Y.Sugawara,T.Matsuda: "Synthesis and Hydrophilicity of Multifunctionally Hydroxylated Poly (acrylamides)" Macromolecules. 29. 313-319 (1996)

N.Saito，Y.Sukawara，T.Matsuda：“多功能羟基化聚（丙烯酰胺）的合成和亲水性”大分子。