Develop of High Performance Stents

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This project aimed to develop high performance stents which enable to reduce the hyperplasia in diseased coronary arteries. Two new approaches were designed and tested : One approach is covered stent in which microporous segmented polyuretheve thin film is wrapped on the stent to prepare a covered stent on which high photoreactive coating enabled sustained release of an incorporated drug. The in vivo study verified that heparin release eventually reduced the intimal hyperpleasia. The other approach is to delivery endothelial progenitor cells (EPC) autologously harvested from the circulating peripheral blood. EPC "paving " from the EPC-seeded stents resulted in full endothelialization at denuded arteries, resulting in rapid wound healing. Thus, the project was completed with high outcome.