Develop of High Performance Stents

高性能支架的开发

• 批准号: 12358017
• 负责人: MATSUDA Takehisa
• 金额: $ 19.1万
• 依托单位: Kyushu University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (A)
• 财政年份: 2000
• 资助国家: 日本
• 起止时间: 2000 至 2002
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-12358017/
• 关键词: stent; covered stent; endothelial cell; エキシマ・レーザ; 光加工

This project aimed to develop high performance stents which enable to reduce the hyperplasia in diseased coronary arteries. Two new approaches were designed and tested : One approach is covered stent in which microporous segmented polyuretheve thin film is wrapped on the stent to prepare a covered stent on which high photoreactive coating enabled sustained release of an incorporated drug. The in vivo study verified that heparin release eventually reduced the intimal hyperpleasia. The other approach is to delivery endothelial progenitor cells (EPC) autologously harvested from the circulating peripheral blood. EPC "paving " from the EPC-seeded stents resulted in full endothelialization at denuded arteries, resulting in rapid wound healing. Thus, the project was completed with high outcome.

该项目旨在开发能够减少病变冠状动脉增生的高性能支架。设计并测试了两种新方法：一种方法是覆膜支架，其中微孔分段聚氨酯薄膜包裹在支架上，以制备覆膜支架，其上的高光反应涂层能够持续释放掺入的药物。体内研究证实，肝素释放最终减少内膜增生。另一种方法是递送从循环外周血中自体收获的内皮祖细胞（EPC）。EPC“铺路”从EPC接种支架导致在裸露的动脉完全内皮化，导致快速伤口愈合。因此，该项目以高成果完成。

项目成果

Nishi S, Nakayama Y, Ueda-Ishibashi H, Matsuda T.: "Embolization of experimental aneurysms using a heparin-loaded stent graft with micropores"Cardiovasc Radiat Med. 4(1). 23-33 (2003)

Nishi S、Nakayama Y、Ueda-Ishibashi H、Matsuda T.：“使用带微孔的肝素负载支架移植物栓塞实验性动脉瘤”Cardiovasc Radiat Med。

Takehisa Matsuda, Hongbing He: "Newly Designed Compliant Hierarchic Hybrid Vascular Grafts Wrapped with a Microprocessed Elastomeric Film(I) : Fabrication Procedure and Compliance Matching"Cell Transplantation. 11. 67-74 (2002)

Takehisa Matsuda，何红兵：“新设计的微加工弹性薄膜包裹的顺应性分层混合血管移植物（I）：制造程序和顺应性匹配”细胞移植。

S.Kidoaki, S.Ohya, Y.Nakayama, T.Matsuda: "Thermoresponsive Structural Change of a Poly(N-isopropylacrylamide) Graft Layer Measured with an Atomic Force Microscope"Lanamuir. 17(8). 2402-2407 (2001)

S.Kidoaki、S.Ohya、Y.Nakayama、T.Matsuda：“用原子力显微镜测量的聚（N-异丙基丙烯酰胺）接枝层的热响应结构变化”Lanamuir。

Takehisa Matsuda, Tomoko Magoshi: "Terminally Alkylated Heparin. 1. Antithrombogenic Surface Modifier"Biomacromolecules. 2(4). 1169-1177 (2001)

Takehisa Matsuda、Tomoko Magoshi：“末端烷基化肝素。1.抗血栓形成表面改性剂”生物大分子。

Nishi S, Nakayama Y, Ishibashi-Ueda H, Matsuda T.: "Occulusion of Experimental Aneurysms with Heparin-Loaded, Microporous Stent Grafts"Reprinted from Nerurosurgery. Vol.53,Number6. 1397-1405 (2003)

Nishi S、Nakayama Y、Ishibashi-Ueda H、Matsuda T.：“用装载肝素的微孔支架移植物进行实验性动脉瘤闭塞”，转载自《神经外科》。