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虚血による心筋細胞障害とその防御機構

缺血引起的心肌细胞损伤及其防御机制

基本信息

批准号：
62624005
负责人：
中村元臣
金额：
$ 10.24万
依托单位：
Kyushu University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research on Priority Areas
财政年份：
1987
资助国家：
日本
起止时间：
1987 至无数据
项目状态：
已结题

项目摘要

本研究班では虚血による心筋細胞障害の発生, 進展その防御機序について実験的に検討した.中村(九大・心研)はランゲンドルフ心について再潅流障害とカルシウムパラドックスについてその発生機序を明らかにし, 更に, invivaにおける心筋虚血の発生機序をミニ豚を用いて検討した.細田(自治医大・循環器内科)は心筋の障害過程に生成する代謝指標を純粋に検出するために, 培養心筋細胞を用い蛍光プローブにより心筋細胞内のCaイオン及びphの測定法を確立した.虚血心筋障害にリボキシゲナーゼが重要な役割を演じているので, 山本(徳島大・生化学)は心筋虚血時の重要な代謝マーカーである5-リポキシゲナーゼを単離しそのモンクローナル抗体を調製した.井上(阪大・医療情報学)は犬冠動脈内にマイクロスフェアを注入し微小血栓モデルを作製して心筋虚血における微小循環反応のケミカルヌヂェータを役割を検討した. 居石(九大・病理)は線溶系の活性化機構と虚血心筋障害の進展との関連を検討した.心筋虚血に伴い副血行路が発達するので, その血管新生機序を金沢(秋田大・内科)は犬を用いて解析した.心臓手術に際して心筋保護は手術成績の向上に重要な要因となるので, 徳永(九大・心臓外科)は心筋保護の最適条件を実験的に検討した. 特に, 潅流液の温度が再潅流障害及び活性酸素に与える影響を明かにした.金子(東京女子医大・内科)は冠潅流が維持されている状態で心筋細胞が過収縮過伸展によって壊死に至る機序を犬と家兎のモデルで検討した.

In this research class, there is nothing wrong with the failure of the mind, the barrier of the cell, and the development of the defense mechanism. Nakamura (Nakamura, Ninth Heart Research), there is no need to stop the flow of blood, and the health mechanism of the dolphin is better than that of the dolphin. what's more, the sequence of the health mechanism of the inviva, the heart deficiency, the blood deficiency, the blood deficiency, the heart, the heart, the heart Tian (Department of Environmental Medicine, Autonomous Medical University) is responsible for the generation of mental disorders in the process of mental disorders, which refers to the generation of mental disorders in the process of mental disorders, which refers to the generation of mental disorders in the process of mental disorders, and the use of light-emitting diaphragms to detect intracellular Ca and ph measurements to make sure that they are correct. The deficiency of blood and tendons in the heart is harmful to the body, and the blood deficiency is very important in the performance of the disease. Yamamoto (German University of Biochemistry) plays an important role when the heart is deficient in blood. Inoue (Sakata Medical Information report) Inoue (Sakata Medical Information report) in the dog crown movement, the dog crown was injected with a small thrombus to treat heart deficiency and blood loss. Jushi (nine major pathology) the activation mechanism of insufficiency, blood and heart muscle barrier is in the process of suffering from severe illness. Heart muscle deficiency and blood circulation was accompanied by accessory blood circulation, and the sequence of angiogenesis (Akita University Department of Internal Medicine) was analyzed in dogs. Heart surgery, heart protection, heart protection In particular, the temperature of the flow, the damage of flow and the effect of active acids on the temperature of flow. Jinzi (Department of Internal Medicine of Beijing Women's Medical University) maintains the status of mental illness through stretching and death to the order of the dog.