Asymmetric Addition of carbon, nitrogen, oxygen and sulfur nucleophiles and its application to the synthesis of biologically active compounds

大多数生物活性化合物的手性碳中心直接与碳、氮、氧、硫等代表性原子相连。这4个原子的不对称加成反应发展了有效合成有用药物和生物活性分子的方法。我们实现了有机锂、烯醇化锂、锂酰胺、有机硼烷、有机镁和有机锌的不对称加成。以我们开发的不对称反应为关键步骤，还实现了一些天然产物的不对称全合成。

Most chiral carbon centers of biologically active compound directly connect to representative 4 atoms, carbon, nitrogen, oxygen, and sulfur atoms. Asymmetric addition reaction of these 4 atoms develops the methodology for the efficient synthesis of useful medicines and biologically active molecules. We achieved asymmetric addition of organolithiums, lithium enolates, lithium amides, organoboranes, organomagnesiums, and organozincs. Asymmetric total synthesis of some natural products was also achieved by using our developed asymmetric reaction as a key step.