Asymmetric Addition of carbon, nitrogen, oxygen and sulfur nucleophiles and its application to the synthesis of biologically active compounds

生物活性化合物的大多数手性碳中心直接连接到具有代表性的4个原子上，即碳、氮、氧和硫原子。这4个原子的不对称加成反应为有效合成有用的药物和生物活性分子开辟了方法学。我们实现了有机锂硫化物、烯醇酸锂、锂酰胺、有机硼烷、有机镁和有机锌的不对称加成反应。利用我们开发的不对称反应作为关键步骤，还实现了一些天然产物的不对称全合成。

Most chiral carbon centers of biologically active compound directly connect to representative 4 atoms, carbon, nitrogen, oxygen, and sulfur atoms. Asymmetric addition reaction of these 4 atoms develops the methodology for the efficient synthesis of useful medicines and biologically active molecules. We achieved asymmetric addition of organolithiums, lithium enolates, lithium amides, organoboranes, organomagnesiums, and organozincs. Asymmetric total synthesis of some natural products was also achieved by using our developed asymmetric reaction as a key step.