Research on Development of Biologically Functional Molecules Aiming at DrugDiscovery: An Approach by Creative Organic Syntheses

我们将我们的创新方法推进到环保和可持续的合成一系列具有复杂高维结构的天然产物，这些产物具有有趣的生物活性，但在自然界中只存在于少量中，也是具有活体功能的分子，目的是获得许多用于药物开发的有用化合物。利用这些新合成的化合物，与其他具有原始药物评价系统的研究小组和研究机构合作，开展了基于新机制的新药物靶点的研究。此外，我们还利用我们的合成方法开发了一种无金属的有机材料直接合成方法。

We have advanced our creative methods to environmentally friendly and sustainable synthesis of a series of natural products which have complicated and high dimensional structures showing interesting biological activities but occur only in small amounts in nature, and also living body-functioned molecules for the purpose of obtaining many useful compounds for drug development. Using these newly synthesized compounds, research toward creation of novel medicinal target based on new mechanisms has been performed in collaboration with other research groups and institutes having original drug evaluation systems. Furthermore, we also developed a metal-free direct synthesis of the organic materials using our synthetic methods.