Research on Development of Biologically Functional Molecules Aiming at DrugDiscovery: An Approach by Creative Organic Syntheses

我们已经将我们的创造性方法推进到环境友好和可持续的合成一系列天然产物，这些天然产物具有复杂的高维结构，显示出有趣的生物活性，但在自然界中仅少量存在，以及生物体功能分子，以获得许多有用的化合物用于药物开发。使用这些新合成的化合物，与具有原始药物评价系统的其他研究小组和研究所合作，进行了基于新机制的新型药物靶点的研究。此外，我们还开发了一个无金属的直接合成的有机材料使用我们的合成方法。

We have advanced our creative methods to environmentally friendly and sustainable synthesis of a series of natural products which have complicated and high dimensional structures showing interesting biological activities but occur only in small amounts in nature, and also living body-functioned molecules for the purpose of obtaining many useful compounds for drug development. Using these newly synthesized compounds, research toward creation of novel medicinal target based on new mechanisms has been performed in collaboration with other research groups and institutes having original drug evaluation systems. Furthermore, we also developed a metal-free direct synthesis of the organic materials using our synthetic methods.