Role of 3'-phosphorylated phosphoinositides in neurosecretion
Role of 3'-phosphorylated phosphoinositides in neurosecretion
批准号:
DP0449683
负责人:
Prof Frederic Meunier
金额:
$16.71万
依托单位国家:
澳大利亚
项目类别:
Discovery Projects
财政年份:
2004
资助国家:
澳大利亚
项目状态:
已结题
起止时间:
2004-01-01 至 2007-12-31
中文摘要
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英文摘要
Neurons communicate through the release of neurotransmitter by synaptic vesicles. Minute changes underlie normal processes such as memory and modifications of neurotransmitter level contribute to a number of neurological diseases. I am interested in deciphering the role of phosphoinositides, an inner membrane-based lipid, during steps leading to the fusion of a synaptic vesicle with the plasma membrane. I have recently discovered that phosphatidylinositol-3 phosphate production was critical for the vesicle to acquire the competence to fuse with the plasma membrane. This project aim to understand by which mechanism this lipid interacts with the release machinery to promote such priming step.
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会议论文
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Unveiling the nanoscale organisation and dynamics of synaptic vesicle pools
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资助金额:$46.91万
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财政年份:2019
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负责人:Prof Frederic Meunier
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依托单位:
TAU AND ITS MASTER REGULATOR FYN IN NEURONS
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批准号:nhmrc : 1127999
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项目类别:Project Grants
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资助金额:$51.77万
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财政年份:2017
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负责人:Prof Frederic Meunier
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依托单位:
TAU AND ITS MASTER REGULATOR FYN IN NEURONS
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负责人:Prof Frederic Meunier
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依托单位:
Unravelling a new fatty acid pathway involved in neuroexocytosis and memory
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财政年份:2017
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负责人:Prof Frederic Meunier
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依托单位:
Intra and intermolecular steps underpinning vesicular priming
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批准号:DP170100125
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项目类别:Discovery Projects
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资助金额:$38.52万
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财政年份:2017
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负责人:Prof Frederic Meunier
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依托单位:
Unravelling the mechanism of vesicular docking in neurosecretory cells
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项目类别:Discovery Projects
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资助金额:$30.03万
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财政年份:2015
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负责人:Prof Frederic Meunier
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依托单位:
Vesicular trafficking pathways underpinning neuronal secretion and survival
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批准号:nhmrc : 1060075
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项目类别:Research Fellowships
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资助金额:$46.49万
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负责人:Prof Frederic Meunier
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依托单位:
Vesicular trafficking in neurons in health and disease
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批准号:nhmrc : GNT1060075
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项目类别:Research Fellowships
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资助金额:$66.45万
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财政年份:2014
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负责人:Prof Frederic Meunier
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依托单位:
Live molecular imaging using super resolution microscopy, two photon and spinning disk confocal microscopy
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批准号:LE130100078
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财政年份:2013
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依托单位:
The role of actin in driving bulk endocytosis in neurons and neurosecretory cells
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批准号:DP120104057
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资助金额:$26.98万
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财政年份:2012
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依托单位:
Modulating neuronal secretion by the PI3-kinase pathway
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资助金额:$34.46万
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财政年份:2010
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负责人:Prof Frederic Meunier
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依托单位:
Sustaining neuronal communication through bulk endocytosis
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批准号:DP0987669
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项目类别:Discovery Projects
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财政年份:2009
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负责人:Prof Frederic Meunier
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依托单位:
Uncoupled Research Fellowship
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批准号:nhmrc : 569596
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项目类别:NHMRC Research Fellowships
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资助金额:$38.72万
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财政年份:2009
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负责人:Prof Frederic Meunier
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依托单位:
High Speed Fluorescence Imaging coupled with Total Internal Reflection Microscopy and Fluorescence Recovery After Photobleaching System
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批准号:LE0882864
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项目类别:Linkage Infrastructure, Equipment and Facilities
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资助金额:$17.34万
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财政年份:2008
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负责人:Prof Frederic Meunier
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依托单位:
Deciphering the molecular steps leading to the potentiation of neuronal exocytosis by arachidonic acid
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批准号:nhmrc : 351434
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项目类别:NHMRC Project Grants
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资助金额:$18.2万
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财政年份:2005
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依托单位:
Glycerotoxin, a unique tool to investigate the dynamic interactions between N-type Ca2+ channels and the exo-endocytic machinery
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负责人:Prof Frederic Meunier
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依托单位:
国内基金
海外基金
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批准号:30971223
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项目类别:面上项目
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资助金额:31.0万元
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批准年份:2009
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负责人:朱健华
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依托单位: