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Role of 3'-phosphorylated phosphoinositides in neurosecretion

Role of 3'-phosphorylated phosphoinositides in neurosecretion
3-磷酸化磷酸肌醇在神经分泌中的作用
批准号:
DP0449683
负责人:
Prof Frederic Meunier
金额:
$16.71万
依托单位国家:
澳大利亚
项目类别:
Discovery Projects
财政年份:
2004
资助国家:
澳大利亚
项目状态:
已结题
起止时间:
2004-01-01 至 2007-12-31

项目摘要

项目成果

Prof Frederic Meunier的其他基金

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中文摘要
翻译
神经元通过突触小泡释放神经递质进行交流。微小的变化是正常过程的基础,如记忆和神经递质水平的改变导致了许多神经疾病。我有兴趣破译肌醇磷脂在导致突触小泡与质膜融合的步骤中的作用,这是一种基于内膜的脂质。我最近发现,磷脂酰肌醇-3磷酸的产生对于囊泡获得与质膜融合的能力至关重要。这个项目的目的是了解这种脂质是通过什么机制与释放机制相互作用来促进这种启动步骤的。
英文摘要
Neurons communicate through the release of neurotransmitter by synaptic vesicles. Minute changes underlie normal processes such as memory and modifications of neurotransmitter level contribute to a number of neurological diseases. I am interested in deciphering the role of phosphoinositides, an inner membrane-based lipid, during steps leading to the fusion of a synaptic vesicle with the plasma membrane. I have recently discovered that phosphatidylinositol-3 phosphate production was critical for the vesicle to acquire the competence to fuse with the plasma membrane. This project aim to understand by which mechanism this lipid interacts with the release machinery to promote such priming step.
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会议论文
Role of Tau and Synapsin in clustering distinct synaptic vesicle pools
  • 批准号:
    DP230102278
  • 项目类别:
    Discovery Projects
  • 资助金额:
    $33.68万
  • 财政年份:
    2023
  • 负责人:
    Prof Frederic Meunier
  • 依托单位:
Super-resolving neurotransmitter release machinery during priming
  • 批准号:
    DP220102334
  • 项目类别:
    Discovery Projects
  • 资助金额:
    $41.33万
  • 财政年份:
    2022
  • 负责人:
    Prof Frederic Meunier
  • 依托单位:
Nanoscale imaging of presynaptic proteins in health and disease
  • 批准号:
    nhmrc : GNT1155794
  • 项目类别:
    Research Fellowships
  • 资助金额:
    $71.73万
  • 财政年份:
    2019
  • 负责人:
    Prof Frederic Meunier
  • 依托单位:
Unveiling the nanoscale organisation and dynamics of synaptic vesicle pools
  • 批准号:
    DP190100674
  • 项目类别:
    Discovery Projects
  • 资助金额:
    $46.91万
  • 财政年份:
    2019
  • 负责人:
    Prof Frederic Meunier
  • 依托单位:
国内基金
海外基金
Dyrk1A调控CaMKⅡδ的可变剪接及其在心脏重构过程中的作用
  • 批准号:
    30971223
  • 项目类别:
    面上项目
  • 资助金额:
    31.0万元
  • 批准年份:
    2009
  • 负责人:
    朱健华
  • 依托单位: