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Intra and intermolecular steps underpinning vesicular priming

Intra and intermolecular steps underpinning vesicular priming
支持囊泡启动的分子内和分子间步骤
批准号:
DP170100125
负责人:
Prof Frederic Meunier
金额:
$38.52万
依托单位国家:
澳大利亚
项目类别:
Discovery Projects
财政年份:
2017
资助国家:
澳大利亚
项目状态:
已结题
起止时间:
2017-01-01 至 2019-12-31

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中文摘要
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英文摘要
This project aims to discover how secretory vesicles fuse with the plasma membrane, a process called priming. The fusion of secretory vesicles by exocytosis underpins neuronal communication. Despite efforts to understand vesicular fusion, how these vesicles become fusion-competent upon arrival at the plasma membrane is unknown. This project will use single molecule imaging to assess mobility changes of key priming molecules and uncover their diffusional signature during priming. It intends to build a comprehensive model of molecular interactions that make a recently docked vesicle fusion-competent. This understanding is key to unravelling how the brain works
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会议论文
Role of Tau and Synapsin in clustering distinct synaptic vesicle pools
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  • 资助金额:
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  • 财政年份:
    2023
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Super-resolving neurotransmitter release machinery during priming
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  • 财政年份:
    2022
  • 负责人:
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  • 依托单位:
Nanoscale imaging of presynaptic proteins in health and disease
  • 批准号:
    nhmrc : GNT1155794
  • 项目类别:
    Research Fellowships
  • 资助金额:
    $71.73万
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  • 负责人:
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Unveiling the nanoscale organisation and dynamics of synaptic vesicle pools
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  • 项目类别:
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  • 依托单位:
海外基金