Intra and intermolecular steps underpinning vesicular priming
Intra and intermolecular steps underpinning vesicular priming
批准号:
DP170100125
负责人:
Prof Frederic Meunier
金额:
$38.52万
依托单位国家:
澳大利亚
项目类别:
Discovery Projects
财政年份:
2017
资助国家:
澳大利亚
项目状态:
已结题
起止时间:
2017-01-01 至 2019-12-31
中文摘要
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英文摘要
This project aims to discover how secretory vesicles fuse with the plasma membrane, a process called priming. The fusion of secretory vesicles by exocytosis underpins neuronal communication. Despite efforts to understand vesicular fusion, how these vesicles become fusion-competent upon arrival at the plasma membrane is unknown. This project will use single molecule imaging to assess mobility changes of key priming molecules and uncover their diffusional signature during priming. It intends to build a comprehensive model of molecular interactions that make a recently docked vesicle fusion-competent. This understanding is key to unravelling how the brain works
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会议论文
Role of Tau and Synapsin in clustering distinct synaptic vesicle pools
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批准号:DP230102278
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资助金额:$33.68万
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财政年份:2023
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负责人:Prof Frederic Meunier
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依托单位:
Super-resolving neurotransmitter release machinery during priming
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负责人:Prof Frederic Meunier
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依托单位:
Nanoscale imaging of presynaptic proteins in health and disease
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批准号:nhmrc : GNT1155794
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项目类别:Research Fellowships
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资助金额:$71.73万
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财政年份:2019
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负责人:Prof Frederic Meunier
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依托单位:
Unveiling the nanoscale organisation and dynamics of synaptic vesicle pools
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批准号:DP190100674
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项目类别:Discovery Projects
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资助金额:$46.91万
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财政年份:2019
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负责人:Prof Frederic Meunier
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依托单位:
TAU AND ITS MASTER REGULATOR FYN IN NEURONS
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批准号:nhmrc : 1127999
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项目类别:Project Grants
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资助金额:$51.77万
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财政年份:2017
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负责人:Prof Frederic Meunier
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依托单位:
TAU AND ITS MASTER REGULATOR FYN IN NEURONS
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批准号:nhmrc : GNT1127999
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项目类别:Project Grants
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资助金额:$75.87万
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财政年份:2017
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负责人:Prof Frederic Meunier
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依托单位:
Unravelling a new fatty acid pathway involved in neuroexocytosis and memory
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批准号:nhmrc : 1120374
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项目类别:Project Grants
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资助金额:$36.85万
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财政年份:2017
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负责人:Prof Frederic Meunier
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依托单位:
Unravelling the mechanism of vesicular docking in neurosecretory cells
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批准号:DP150100539
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项目类别:Discovery Projects
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资助金额:$30.03万
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财政年份:2015
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负责人:Prof Frederic Meunier
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依托单位:
Vesicular trafficking pathways underpinning neuronal secretion and survival
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批准号:nhmrc : 1060075
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项目类别:Research Fellowships
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资助金额:$46.49万
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财政年份:2014
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负责人:Prof Frederic Meunier
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依托单位:
Vesicular trafficking in neurons in health and disease
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批准号:nhmrc : GNT1060075
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项目类别:Research Fellowships
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资助金额:$66.45万
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财政年份:2014
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负责人:Prof Frederic Meunier
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依托单位:
Live molecular imaging using super resolution microscopy, two photon and spinning disk confocal microscopy
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批准号:LE130100078
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项目类别:Linkage Infrastructure, Equipment and Facilities
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资助金额:$53.34万
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财政年份:2013
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负责人:Prof Frederic Meunier
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依托单位:
The role of actin in driving bulk endocytosis in neurons and neurosecretory cells
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批准号:DP120104057
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项目类别:Discovery Projects
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资助金额:$26.98万
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财政年份:2012
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负责人:Prof Frederic Meunier
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依托单位:
Modulating neuronal secretion by the PI3-kinase pathway
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批准号:nhmrc : 631568
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项目类别:NHMRC Project Grants
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资助金额:$34.46万
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财政年份:2010
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负责人:Prof Frederic Meunier
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依托单位:
Sustaining neuronal communication through bulk endocytosis
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批准号:DP0987669
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项目类别:Discovery Projects
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资助金额:$18.6万
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财政年份:2009
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负责人:Prof Frederic Meunier
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依托单位:
Uncoupled Research Fellowship
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批准号:nhmrc : 569596
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项目类别:NHMRC Research Fellowships
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资助金额:$38.72万
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财政年份:2009
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负责人:Prof Frederic Meunier
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依托单位:
High Speed Fluorescence Imaging coupled with Total Internal Reflection Microscopy and Fluorescence Recovery After Photobleaching System
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批准号:LE0882864
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项目类别:Linkage Infrastructure, Equipment and Facilities
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资助金额:$17.34万
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财政年份:2008
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负责人:Prof Frederic Meunier
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依托单位:
Deciphering the molecular steps leading to the potentiation of neuronal exocytosis by arachidonic acid
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批准号:nhmrc : 351434
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项目类别:NHMRC Project Grants
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资助金额:$18.2万
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财政年份:2005
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负责人:Prof Frederic Meunier
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依托单位:
Glycerotoxin, a unique tool to investigate the dynamic interactions between N-type Ca2+ channels and the exo-endocytic machinery
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批准号:DP0452106
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项目类别:Discovery Projects
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资助金额:$18.8万
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财政年份:2004
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负责人:Prof Frederic Meunier
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依托单位:
Role of 3'-phosphorylated phosphoinositides in neurosecretion
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批准号:DP0449683
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项目类别:Discovery Projects
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资助金额:$16.71万
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财政年份:2004
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负责人:Prof Frederic Meunier
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依托单位:
海外基金