TAU AND ITS MASTER REGULATOR FYN IN NEURONS

神经元中的 TAU 及其主调节器 FYN

• 批准号: nhmrc : 1127999
• 负责人: Prof Frederic Meunier
• 金额: $ 51.77万
• 依托单位: The University of Queensland
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2017
• 资助国家: 澳大利亚
• 起止时间: 2017-01-01 至 2019-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/tau-master-regulator-fyn-neurons/948112
• 关键词: TAU; ITS; MASTER; REGULATOR; FYN

Neurons are highly compartmentalized cell-types. In neurodegenerative diseases such as Alzheimer's disease, the protein Tau that serves a distinct function in one cellular compartment (the axon) accumulates in a massively phosphorylated form elsewhere (somatodendritic compartments and their spines) which is believed to impair neuronal functions. We will investigate how Tau is distributed in health and disease, and determine how this distribution is regulated.

神经元是高度分隔的细胞类型。在神经退行性疾病如阿尔茨海默病中，在一个细胞区室（轴突）中发挥独特功能的Tau蛋白在其他地方（体树突区室及其棘）以大量磷酸化的形式积累，这被认为会损害神经元功能。我们将研究Tau如何在健康和疾病中分布，并确定这种分布是如何调节的。