The role of actin in driving bulk endocytosis in neurons and neurosecretory cells

肌动蛋白在驱动神经元和神经分泌细胞大量内吞作用中的作用

• 批准号: DP120104057
• 负责人: Prof Frederic Meunier
• 金额: $ 26.98万
• 依托单位: The University of Queensland
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2012
• 资助国家: 澳大利亚
• 起止时间: 2012-01-01 至 2014-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP120104057
• 关键词: role; actin; driving; bulk; endocytosis

Synaptic release of neurotransmitter is essential for neuronal communication. Following fusion, synaptic vesicle membrane is incorporated into the plasma membrane and retrieved by endocytosis to recover both lipids and essential vesicular proteins. The project will characterise how the actin cytoskeleton perform this function.

神经递质的突触释放对于神经元通讯至关重要。融合后，突触小泡膜并入质膜并通过内吞作用回收以回收脂质和必需的小泡蛋白。该项目将描述肌动蛋白细胞骨架如何执行此功能。