Unravelling the mechanism of vesicular docking in neurosecretory cells

揭示神经分泌细胞囊泡对接机制

• 批准号: DP150100539
• 负责人: Prof Frederic Meunier
• 金额: $ 30.03万
• 依托单位: The University of Queensland
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2015
• 资助国家: 澳大利亚
• 起止时间: 2015-01-01 至 2018-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP150100539
• 关键词: Unravelling; mechanism; vesicular; docking; neurosecretory

The fusion of secretory vesicles (SVs) by exocytosis underpins neuronal and hormonal communication. The aim of this project is to unravel all the steps bringing these vesicles to the plasma membrane where they dock. Specifically, we aim to unravel the role for the cytoskeleton in creating an interface where SV confinement leads to the appropriate pairing of molecules mediating the fusion between the vesicles and the plasma membrane. Unravelling these novel molecular mechanisms is essential for our understanding of neuronal function in the healthy nervous and hormonal systems.

分泌囊泡（SV）通过胞吐作用的融合是神经元和激素通讯的基础。这个项目的目的是解开所有的步骤，使这些囊泡的质膜，他们对接。具体而言，我们的目标是解开的作用，细胞骨架在创建一个接口，SV限制导致适当的配对分子介导的囊泡和质膜之间的融合。解开这些新的分子机制对于我们理解健康神经和激素系统中的神经元功能至关重要。