Studies on syntheses and functional analysis of dental glass-ceramics prepared by the sol-gel process

溶胶-凝胶法牙科微晶玻璃的合成及功能分析研究

• 批准号: 09671986
• 负责人: TAIRA Masayuki
• 金额: $ 2.3万
• 依托单位: Osaka University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 1997
• 资助国家: 日本
• 起止时间: 1997 至 1999
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-09671986/
• 关键词: Silica; Sol-gel process; Bioactive implant; Biomaterials; Glass-ceramics; Dental cement; Mono-dispersed spherical; Inorganic filler; 骨芽様細胞; 細胞培養; 動物実験; 生体反応; 歯科用コンポジットレジン; ゾル-ゲル法; 骨芽細胞; セメント; コンポジットレジン; 生体親和性; 水酸基; フィラー; リン酸カルシウム; 生体活

This study investigated the feasibility of the sol-gel process into new silica-based dental biomaterials, and the following experimental results were obtained.(1) 50wt%SiOィイD22ィエD2-20wt%PィイD22ィエD2OィイD25ィエD2-30wt%CaO (SPC) was considered as new bio-degradable implant powder materials. When heated less than 900℃, -OH functional groups remained and α-TCP crystals precipitated in the glass-matrix, which might be useful for new bio-materials such as scaffold for tissue engineering.(2) 50wt%SiOィイD22ィエD2-20wt%AlィイD22ィエD2OィイD23ィエD2-30wt%CaO (SAC) was proved to be chemically reactive with polyacrylic acids, indicating that SAC could be used as cement powder. When heated less than 800℃, -OH functional groups remained and might allow modification with functional organic substance.(3) Commercial mono-dispersed spherical silica powders (EQ) prepared by the sol-gel process were successfully silanated with γ-MPTS. After silane treatment, optical properties of EQ altered. Both diffuse reflectance and refractive index decreased.(4) Sol-gel prepared silica glass-ceramic powders might be useful for future biomedical applications such as DNA-forming base and coating on DNA chipps.

本研究探讨了溶胶-凝胶法制备新型硅基牙科生物材料的可行性，并得到以下实验结果。(1)50wt%SiO纳米D22纳米D2-20wt%P纳米D22纳米D2 O纳米D25纳米D2-30wt%CaO（SPC）被认为是一种新型的生物可降解植入粉末材料。当加热温度低于900℃时，-OH官能团仍保留，α-TCP晶体在玻璃基质中析出，这可能是一种新型生物材料，如组织工程支架。(2)50wt%SiO_2·D_22·D_2 -20wt%Al·D_22·D_2O·D_23·D_2 -30wt%CaO（SAC）与聚丙烯酸具有化学反应性，表明SAC可用作水泥粉料。当加热温度低于800℃时，-OH官能团仍然存在，可能允许功能有机物的修饰。(3)用γ-MPTS对溶胶-凝胶法制备的单分散球形SiO2粉体进行了硅烷化改性。经硅烷处理后，EQ的光学性质发生了变化。漫反射率和折射率均下降。(4)溶胶-凝胶法制备的石英玻璃陶瓷粉体在生物医学领域有着广阔的应用前景，如DNA基片和DNA芯片涂层等。

项目成果

TAIRA, M., OKAZAKI, M. and TAKAHASHI, J.: "Characterization of 50wt% SiO_2-20wt%P_2O_5-30wt%CaO glass-ceramic powders prepared by the sol-gel process"Dental Materials Journal. 16・2. 117-126 (1997)

TAIRA, M., OKAZAKI, M. 和 TAKAHASHI, J.：“溶胶-凝胶法制备的 50wt% SiO_2-20wt%P_2O_5-30wt%CaO 玻璃陶瓷粉末的表征”《牙科材料杂志》16・2。 -126 (1997)

TAIRA, M., OKAZAKI, M., TAKAHASHI, M. and KUBO. F.: "Effects of four mixing methods on setting expansion and compressive strength of six commercial phosphate-bonded silica investments."J. Oral Rehabil.. 27 (in press).

平，M.，冈崎，M.，高桥，M.和久保。

Taira M.,Okazaki M.and Takahashi J.: "Studies on optical properties of two commercial visible-light-Cured composite resins by diffuse reflectance measurements"J.Oral Rehabilitation. 26・4. 329-337 (1999)

Taira M.、Okazaki M. 和 Takahashi J.：“通过漫反射测量研究两种商业可见光固化复合树脂的光学性能”J. Oral Rehabilitation 26・4 (1999)。

Matsumoto T.,Okazaki M.,Taira M.and Takahashi J.: "Inhibiting action of carbohydrates on the growth of fluorapatite crystals"Caries Res.. 34・1. 26-32 (2000)

松本T.、冈崎M.、平M.、高桥J.：“碳水化合物对氟磷灰石晶体生长的抑制作用”Caries Res. 34・1（2000）。

Taira M.,Okazaki M.,Takahashi J.and Kubo F.: "Effects of four mixing methods on setting expansion and compressive strength of six phosphate-bonded silica"J.Oral Rehabilitation. 27(印刷中). (2000)

Taira M.、Okazaki M.、Takahashi J. 和 Kubo F.：“四种混合方法对六种磷酸盐键合二氧化硅的凝固膨胀和压缩强度的影响”J. Oral Rehabilitation 27（出版中）。