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Fundamental study for the development of a low porous vascular graft which has a high healing property, soft and pliable characteristics.

开发具有高愈合性能、柔软和柔韧特性的低孔血管移植物的基础研究。

基本信息

批准号：
62570638
负责人：
NOISHIKI Yasuharu
金额：
$ 1.41万
依托单位：
Okayama University
依托单位国家：
日本
项目类别：
Grant-in-Aid for General Scientific Research (C)
财政年份：
1987
资助国家：
日本
起止时间：
1987 至 1988
项目状态：
已结题

项目摘要

Compliance, suturability and healing are major important properties of vascular grafts. However, in low porosity grafts developed so far, the poor easiness of suturing and the delayed healing due to the rigidity derived from the tightly woven or knitted structure remain as unsolved problems.In order to improve the above-mentioned drawbacks, a new low porosity vascular graft has been developed using ultra-fine polyester fiber (UFPF, 0.12 denier, 3.0 um in diameter)Thirty grafts (water porosity: 100 ml/cm^2, diameter:8 mm, length:5.7 cm) have been implanted in the thoracic aorta of mongrel dogs for one to 255 days. For control, the commercial vascular grafts (porosity: 400 ml/cm^2) fabricated from polyester fiber (2.0 denier, 20 um in diameter) were evaluated in the same manner.The UFPF graft was very pliable and found easy in sutureing and handling. The histological studies on the implanted UFPF grafts revealed that the infiltration of fibroblasts into the interstices among the fibers was significantly accelerated and the capillary formation was also recognized even in the early stage and the endothelialization was completed about 85 days, while in the control grafts, no full infiltration of fibroblasts was observed in the later stage of implantation.These findings suggest that thinning of the fibers significantly enhances both of the anchoring effect of the graft to the cells and of the compatibility of the fibers to the cell, leading to the acceleration of healing process of the vascular grafts.

顺应性、可缝合性和愈合性是血管移植的重要特性。然而，在目前开发的低孔隙度移植物中，由于紧密编织或编织结构的刚性而导致的缝合性差和愈合延迟仍然是尚未解决的问题。为了改善上述缺点，利用超细聚酯纤维（UFPF， 0.12旦，直径3.0 um）研制了一种新型低孔隙度血管移植物。在杂种狗的胸主动脉中植入30个（水孔隙度：100 ml/cm^2，直径：8 mm，长度：5.7 cm）移植物1 ~ 255天。作为对照，用聚酯纤维（2.0旦，直径20微米）制成的商业血管移植物（孔隙度：400 ml/cm^2）以相同的方式进行评估。UFPF移植物柔韧性好，易于缝合和操作。对植入的UFPF移植物进行组织学研究发现，成纤维细胞向纤维间隙的浸润明显加快，即使在早期也能识别毛细血管形成，内皮化约在85天完成，而对照移植物在植入后期未观察到成纤维细胞的完全浸润。这些结果表明，纤维变薄可以显著增强移植物对细胞的锚定作用和纤维与细胞的相容性，从而加速血管移植物的愈合过程。