Fundamental study for the development of a low porous vascular graft which has a high healing property, soft and pliable characteristics.

顺应性、可缝合性和愈合性是血管移植物的主要重要特性。然而，在迄今为止开发的低孔隙度血管移植物中，由于紧密编织或针织结构产生的刚性而导致的不易缝合和延迟愈合仍然是未解决的问题，为了改善上述缺点，已经使用超细聚酯纤维开发了新的低孔隙度血管移植物（UFPF，0.12旦尼尔，直径3.0 μ m）将30个移植物（水孔隙度：100 ml/cm ^2，直径：8 mm，长度：5.7 cm）植入杂种犬的胸主动脉中1 - 255天。作为对照，以相同的方式评价由聚酯纤维（2.0旦尼尔，直径20 μ m）制成的商业血管移植物（孔隙率：400 ml/cm ^2）。对植入的UFPF移植物的组织学研究显示，成纤维细胞向纤维间的间隙中的浸润显著加速，并且即使在早期也识别到毛细血管形成，并且内皮化在约85天完成，而在对照移植物中，在植入后期没有观察到成纤维细胞的充分浸润。这些发现表明，纤维变细显著增强了锚定和细胞增殖。移植物对细胞的作用以及纤维对细胞的相容性，导致血管移植物的愈合过程加速。

Compliance, suturability and healing are major important properties of vascular grafts. However, in low porosity grafts developed so far, the poor easiness of suturing and the delayed healing due to the rigidity derived from the tightly woven or knitted structure remain as unsolved problems.In order to improve the above-mentioned drawbacks, a new low porosity vascular graft has been developed using ultra-fine polyester fiber (UFPF, 0.12 denier, 3.0 um in diameter)Thirty grafts (water porosity: 100 ml/cm^2, diameter:8 mm, length:5.7 cm) have been implanted in the thoracic aorta of mongrel dogs for one to 255 days. For control, the commercial vascular grafts (porosity: 400 ml/cm^2) fabricated from polyester fiber (2.0 denier, 20 um in diameter) were evaluated in the same manner.The UFPF graft was very pliable and found easy in sutureing and handling. The histological studies on the implanted UFPF grafts revealed that the infiltration of fibroblasts into the interstices among the fibers was significantly accelerated and the capillary formation was also recognized even in the early stage and the endothelialization was completed about 85 days, while in the control grafts, no full infiltration of fibroblasts was observed in the later stage of implantation.These findings suggest that thinning of the fibers significantly enhances both of the anchoring effect of the graft to the cells and of the compatibility of the fibers to the cell, leading to the acceleration of healing process of the vascular grafts.