Fundamental study of an anti-adhesive membrane for thoracic surgeries

胸外科防粘连膜的基础研究

• 批准号: 22390268
• 负责人: NOISHIKI Yasuharu
• 金额: $ 12.48万
• 依托单位: Yokohama City University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2010
• 资助国家: 日本
• 起止时间: 2010 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22390268/
• 关键词: 癒着防止膜; 外科; 細胞・組織; 臨床; 組織・細胞

A pilot study for an anti-adhesive membrane for thoracic surgeries especially for the pleural cavity surgery was performed. A biodegradable membrane made of gelatin or hyaluronic-acid containing a certain amount of glycerin was developed. In vivo and in vitro studies showed that the tested membranes were effective to prevent adhesion in the pleural cavity. The mechanism of these desirable results was as follows. The membranes contained glycerin, which gathered and dispersed abundant water. Together with this, growth factors are also dispersed, resulting in dilution of excessive growth factors at the wound sites.

初步研究了一种用于胸部手术，特别是胸腔手术的防粘附膜。以明胶或含有一定量甘油的透明质酸为原料，制备了一种生物可降解膜。体内和体外研究表明，所测试的膜能有效地防止胸腔内的粘连。这些令人满意的结果的机理如下。这些膜含有甘油，可以聚集和分散大量的水。此外，生长因子也被分散，导致伤口处过量的生长因子被稀释。

项目成果

癒着防止膜の現状。水の動きと細胞の動き

防粘连膜的现状。

• 发表时间: 2012
• 作者: 野一色泰晴;伊藤博
• 通讯作者: 伊藤博